Spongiatriol inhibits nuclear factor kappa B activation and induces apoptosis in pancreatic cancer cells

Marine Drugs

Volumn 11, Issue 4, 2013, Pages 1140-1151

  Guzmán, Esther ^a   Maher, Michael ^a   Temkin, Alexis ^a   Pitts, Tara ^a   Wright, Amy ^a  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

Apoptosis; Inflammation; Nuclear factor kappa B; Pancreatic cancer

Indexed keywords

CASPASE 3; CASPASE 7; DISCALAMIDE A; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOBATZELLINE C; LUCIFERIN; MYCALAMIDE B; ONNAMIDE A; PRIANOSIN A; SECOBATZELLINE A; SPONGIATRIOL; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER MORTALITY; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; NICK END LABELING; PANCREAS CANCER; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

EID: 84876981218     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md11041140     Document Type: Article

References (21)

1. Pancreatic Cancer. Available online: http://www.cancer.org/Cancer/ PancreaticCancer/DetailedGuide/index (accessed on 9 March 2012).
2. Vakkila, J.; Lotze, M.T. Inflammation and necrosis promote tumour growth. Nat. Rev. Immunol. 2004, 4, 641-648.
3. Coussens, L.M.; Werb, Z. Inflammation and cancer. Nature 2002, 420, 860-867.
4. Balkwill, F.; Charles, K.A.; Mantovani, A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005, 7, 211-217.
5. Theoharides, T.C. Mast cells and pancreatic cancer. N. Engl. J. Med. 2008, 358, 1860-1861.
6. Esposito, I.; Menicagli, M.; Funel, N.; Bergmann, F.; Boggi, U.; Mosca, F.; Bevilacqua, G.; Campani, D. Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. J. Clin. Pathol. 2004, 57, 630-636.
7. Farrow, B.; Sugiyama, Y.; Chen, A.; Uffort, E.; Nealon, W.; Mark Evers, B. Inflammatory mechanisms contributing to pancreatic cancer development. Ann. Surg. 2004, 239, 763-769.
8. Ben-Neriah, Y.; Karin, M. Inflammation meets cancer, with NF-kappaB as the matchmaker. Nat. Immunol. 2011, 12, 715-723.
9. Wang, W.; Abbruzzese, J.L.; Evans, D.B.; Larry, L.; Cleary, K.R.; Chiao, P.J. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin. Cancer Res. 1999, 5, 119-127.
10. Fujioka, S.; Sclabas, G.M.; Schmidt, C.; Frederick, W.A.; Dong, Q.G.; Abbruzzese, J.L.; Evans, D.B.; Baker, C.; Chiao, P.J. Function of nuclear factor kappaB in pancreatic cancer metastasis. Clin. Cancer Res. 2003, 9, 346-354.
11. Kazlauskas, R.; Murphy, P.T.; Wells, R.J.; Noack, K.; Oberhaensli, W.E.; Schoenholzer, P. A new series of diterpenes from Australian Spongia species. Aust. J. Chem. 1979, 32, 867-880.
12. Burres, N.S.; Clement, J.J. Antitumor activity and mechanism of action of the novel marine natural products mycalamide-A and -B and onnamide. Cancer Res. 1989, 49, 2935-2940.
13. Lee, K.H.; Nishimura, S.; Matsunaga, S.; Fusetani, N.; Horinouchi, S.; Yoshida, M. Inhibition of protein synthesis and activation of stress-activated protein kinases by onnamide A and theopederin B, antitumor marine natural products. Cancer Sci. 2005, 96, 357-364.
14. Guzman, E.A.; Johnson, J.D.; Carrier, M.K.; Meyer, C.I.; Pitts, T.P.; Gunasekera, S.P.; Wright, A.E. Selective cytotoxic activity of the marine-derived batzelline compounds against pancreatic cancer cell lines. Anticancer Drugs 2009, 20, 149-155.
15. Gupta, S.C.; Sundaram, C.; Reuter, S.; Aggarwal, B.B. Inhibiting NF-κB activation by small molecules as a therapeutic strategy. Biochim. Biophys. Acta 2010, 1799, 775-787.
16. Braeuer, S.J.; Büneker, C.; Mohr, A.; Zwacka, R.M. Constitutively activated nuclear factor-κB, but not induced NF-κB, leads to TRAIL resistance by up-regulation of X-linked inhibitor of apoptosis protein in human cancer cells. Mol. Cancer Res. 2006, 4, 715-728.
17. Yang, L.; Cao, Z.; Yan, H.; Wood, W.C. Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy. Cancer Res. 2003, 63, 6815-6824.
18. Gupta, S.C.; Prasad, S.; Reuter, S.; Kannappan, R.; Yadav, V.R.; Ravindran, J.; Hema, P.S.; Chaturvedi, M.M.; Nair, M.; Aggarwal, B.B. Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents. J. Biol. Chem. 2010, 285, 35406-35417.
19. Marwood, J.F. Investigations into the pharmacological effects of spongiatriol. Aust. J. Exp. Biol. Med. Sci. 1982, 60, 253-263.
20. Takahashi, H.; Schumann, R.; Quinn, R.; Briscoe, T.A.; Parsons, P.G. Isomers of a marine diterpene distinguish sublines of human melanoma cells on the basis of apoptosis, cell cycle arrest and differentiation markers. Melanoma Res. 1992, 1, 359-366.
21. Zoretic, P.A.; Zhang, Y.; Fang, H.; Ribeiro, A.A.; Dubay, G. Advanced tetracycles in a stereoselective approach to D,L-spongiatriol and related metabolites: The use of radicals in the synthesis of angular electrophores. J. Org. Chem. 1998, 63, 1162-1167.