Differential effects of the CpG-toll-like receptor 9 axis on pregnancy outcome in nonobese diabetic mice and wild-type controls

Fertility and Sterility

Volumn 99, Issue 6, 2013, Pages

  Sun, Yun ^a   Qin, Xiaoli ^a   Shan, Bin ^b   Wang, Wenjing ^a   Zhu, Qinling ^a   Sharma, Surendra ^c   Wu, Ji ^d   Lin, Yi ^e  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c BROWN UNIVERSITY   (United States)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

^e SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Animal model; cell signaling; fetomaternal interface; immune modulation; immune tolerance

Indexed keywords

CD11B ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CPG TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FETUS RESORPTION; FLOW CYTOMETRY; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PREGNANCY OUTCOME; PREMATURE LABOR; PRIORITY JOURNAL; SPONTANEOUS ABORTION; UTERUS;

EID: 84876970289     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2013.01.121     Document Type: Article

References (33)

1. M. Salker, G. Teklenbueg, M. Molokhia, S. Lavery, G. Trew, and T. Aojanepong Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss PLoS One 5 2010 e10287
2. N.S. Macklon, J.P. Geraedts, and B.C. Fauser Conception to ongoing pregnancy: the "black box" of early pregnancy loss Hum Reprod Update 8 2002 333 343
3. R. Rai, and L. Regan Recurrent miscarriage Lancet 368 2006 601 611
4. R. Romero, J. Espinoza, and M. Mazor Can endometrial infection/ inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertil Steril 82 2004 799 804
5. J. Hanna, D. Goldman-Wohl, Y. Hamani, I. Avraham, C. Greenfield, and S. Natanson-Yaron Decidual NK cells regulate key developmental processes at the human fatal-maternal interface Nat Med 12 2006 1065 1074
6. S. Kalkunte, C.O. Chichester, F. Gotsch, C.L. Sentman, R. Romero, and S. Sharma Evolution of non-cytotoxic uterine natural killer cells Am J Reprod Immunol 59 2008 425 432
7. S.S. Kalkunte, T.F. Mselle, W.E. Norris, C.R. Wira, C.L. Sentman, and S. Sharma Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface J Immunol 182 2009 4085 4092
8. + natural killer cell transfer in sub-fertile NOD mice Reprod BioMed Online 18 2009 95 103
9. + natural killer-cell transfer Reproduction 137 2009 943 955
10. S.P. Murphy, L.D. Fast, N.N. Hanna, and S. Sharma Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null mice J Immunol 175 2005 4084 4090
11. S.P. Murphy, N.N. Hanna, L.D. Fast, S.K. Shaw, G. Berg, and J.F. Padbury Evidence for participation of uterine NK cells in the mechanisms responsible for spontaneous preterm labor and delivery Am J Obstet Gynecol 200 2009 308.e1 308.e9
12. J.E. Thaxton, R. Romero, and S. Sharma TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes J Immunol 183 2009 1144 1154
13. G. Pedersen, L. Andresen, M.W. Matthiessen, J. Rask-Madsen, and J. Brynskov Expression of toll-like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium Clin Exp Immunol 141 2005 298 306
14. M.R. Prater, V.J. Johnson, D.R. Germolec, M.I. Luster, and S.D. Holladay Maternal treatment with a high dose of CpG ODN during gestation alters fetal craniofacial and distal limb development in C57BL/6 mice Vaccine 24 2006 263 271
15. Y. Meng, A.F. Carpentier, L. Chen, G. Boisserie, J.M. Simon, and J.J. Mazeron Successful combination of local CpG-ODN and radiotherapy in malignant glioma Int J Cancer 116 2005 992 997
16. Y. Lin, Y. Chen, Y. Zeng, T. Wang, and S. Zeng Lymphocyte phenotyping and NK cell activity analysis in pregnant NOD/SCID mice J Reprod Immunol 68 2005 39 51
17. A.C. Rocha-Campos, R. Melki, R. Zhu, N. Deruytter, D. Damotte, and M. Dy Genetic and functional analysis of the Nkt1 locus using congenic NOD mice: improved Vα14-NKT cell performance but failure to protect against type 1 diabetes Diabetes 55 2006 1163 1170
18. Y. Lin, Z. Liang, Y. Chen, and Y. Zeng TLR3-involved modulation of pregnancy tolerance in double-stranded RNA-stimulated NOD/SCID mice J Immunol 176 2006 4147 4154
19. + T cell migration and prevents embryo loss in NOD mice Fertil Steril 91 2009 2687 2696
20. C. Li, W. Wang, H. Wang, Y. Zhong, J. Di, and Y. Lin Proteomic analysis of proteins differentially expressed in uterine lymphocytes obtained from wild-type and NOD mice J Cell Biochem 108 2009 447 457
21. G. Yin, C. Li, B. Shan, W. Wang, H. Chen, and Y. Zhong Insufficient peroxiredoxin-2 expression in uterine NK cells obtained from a murine model of abortion J Cell Biochem 112 2011 773 781
22. A.M. Dragoi, X. Fu, S. Ivanov, P. Zhang, L. Sheng, and D. Wu DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA EMBO J 24 2005 779 789
23. D. Verthelyi, and A.R. Zeuner Differential signaling by CpG DNA in DCs and B cells: not just TLR9 Trends Immunol 24 2003 519 522
24. I. Gursel, M. Gursel, H. Yamada, K.J. Ishii, F. Takeshita, and D.M. Klinman Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation J Immunol 171 2003 1393 1400
25. J. Trowsdale, and A.G. Betz Mother's little helpers: mechanisms of maternal-fetal tolerance Nat Immunol 7 2006 241 246
26. E. Nardini, D. Morelli, P. Aiello, D. Besusso, C. Calcaterra, and L. Mariani CpG-oligodeoxynucleotides induce mobilization of hematopoetic progenitor cells into peripheral blood in association with mouse KC (IL-8) production J Cell Physiol 204 2005 889 895
27. D.M. Klinman Adjuvant activity of CpG oligodeoxynucleotides Int Rev Immunol 25 2006 135 154
28. M.V. Pararas, C.L. Skevaki, and D.A. Kafetzis Preterm birth due to maternal infection: causative pathogens and modes of prevention Eur J Clin Microbiol Infect Dis 25 2006 562 569
29. S. Uematsu, and S. Akira Toll-like receptors and innate immunity J Mol Med 84 2006 712 725
30. U. Bhan, N.W. Lukacs, J.J. Osterholzer, M.W. Newstead, X. Zeng, and T.A. Moore TLR9 is required for protective innate immunity in Gram-negative bacterial pneumonia: role of dendritic cells J Immunol 179 2007 3937 3946
31. Y. Lin, L. Ren, W. Wang, J. Di, S. Zeng, and S. Saito Effect of TLR3 and TLR7 activation in uterine NK cells from non-obese diabetic (NOD) mice J Reprod Immunol 82 2009 12 23
32. S.H. Lee, K.S. Kim, N. Fodil-Cornu, S.M. Vidal, and C.A. Biron Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection J Exp Med 206 2009 2235 2251
33. Y. Filipovich, S.J. Lu, S. Akira, and E. Hirsch The adaptor protein MyD88 is essential for E coli-induced preterm delivery in mice Am J Obstet Gynecol 200 2009 93.e1 93.e8