Branch retinal vein occlusion: Epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature

Retina

Volumn 33, Issue 5, 2013, Pages 901-910

  Jaulim, Adil ^a   Ahmed, Badia ^a   Khanam, Tina ^b   Chatziralli, Irini P ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b BARTS HEALTH NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTITHROMBIN; BLOOD CLOTTING FACTOR 5 LEIDEN; CARDIOLIPIN ANTIBODY; ENDOTHELIN 1; HYPOXIA INDUCIBLE FACTOR 1; INTERLEUKIN 6; INTERLEUKIN 8; LUPUS ANTICOAGULANT; MONOCYTE CHEMOTACTIC PROTEIN 1; PIGMENT EPITHELIUM DERIVED FACTOR; PROTEIN C; PROTHROMBIN; VASCULOTROPIN; VASCULOTROPIN C;

ARTERIAL STIFFNESS; BRANCH RETINAL VEIN OCCLUSION; CENTRAL RETINA VEIN OCCLUSION; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DNA POLYMORPHISM; HUMAN; HYDROSTATIC PRESSURE; HYPERCOAGULABILITY; HYPERHOMOCYSTEINEMIA; HYPERLIPIDEMIA; HYPERTENSION; INCIDENCE; INTRAOCULAR HEMORRHAGE; META ANALYSIS (TOPIC); OPHTHALMOSCOPY; OPTICAL COHERENCE TOMOGRAPHY; PATHOGENESIS; PIGMENT EPITHELIUM; PULSE WAVE; RETINA DETACHMENT; RETINA EDEMA; RETINA FLUORESCEIN ANGIOGRAPHY; RETINA MACULA CYSTOID EDEMA; RETINA MACULA EDEMA; RETINA MACULOPATHY; RETINA NEOVASCULARIZATION; RETINAL TELANGIECTASIA; RETINAL THICKNESS; REVIEW; RISK FACTOR; THROMBOPHILIA; UPREGULATION; VISUAL ACUITY; VITREOUS HEMORRHAGE;

BLOOD FLOW VELOCITY; HUMANS; INCIDENCE; RETINAL VEIN OCCLUSION; RETINAL VESSELS; RISK FACTORS; VISUAL ACUITY;

EID: 84876955894     PISSN: 0275004X     EISSN: 15392864     Source Type: Journal    
DOI: 10.1097/IAE.0b013e3182870c15     Document Type: Review

References (146)

1. Klein R, Klein BE, Moss SE, Meuer SM. The epidemiology of retinal vein occlusion: The Beaver Dam Eye Study. Trans Am Ophthalmol Soc 2000;98:133-141.
2. Rehak J, Rehak M. Branch retinal vein occlusion: Pathogenesis, visual prognosis, and treatment modalities. Curr Eye Res 2008;33:111-131.
3. Hayreh SS, Zimmerman MB, Podhajsky P. Incidence of various types of retinal vein occlusion and their recurrence and demographic characteristics. Am J Ophthalmol 1994;117: 429-441.
4. Parodi MB, Bandello F. Branch retinal vein occlusion: Classification and treatment. Ophthalmologica 2009;223: 298-305.
5. Jonas J, Paques M, Monés J, Glacet-Bernard A. Retinal vein occlusions. Dev Ophthalmol 2010;47:111-135.
6. Coscas G, Loewenstein A, Augustin A, et al. Management of retinal vein occlusion- consensus document. Ophthalmologica 2011;226:4-28.
7. Appiah AP, Trempe CL. Differences in contributory factors among hemicentral, central, and branch retinal vein occlusions. Ophthalmology 1989;96:364-366.
8. Parodi MB, Moretti G, Ravalico G. Hemicentral and hemispheric retinal vein occlusions. Metab Pediatr Syst Ophthalmol 1992;15:64-67.
9. Leber T. Die Krankheite der Netzhaut und des Sehnerven. In: Graefe-Saemisch. Handbuch der Gesamten Augenheikunde. Leipzig: Verlag von Wilhelm Engelmann; 1877:531.
10. Hayreh SS. Prevalent misconceptions about acute retinal vascular occlusive disorders. Prog Retin Eye Res 2005;24: 493-519.
11. Lang GE, Freissler K. Clinical and fluorescein angiography findings in patients with retinal vein occlusion. A unicenter study of 211 patients. Klin Monbl Augenheilkd 1992;201: 234-239.
12. Thapa R, Paudyal G, Bernstein PS. Demographic characteristics, patterns and risk factors for retinal vein occlusion in Nepal: A hospital-based case-control study. Clin Experiment Ophthalmol 2010;38:583-590.
13. Rogers S, McIntosh RL, Cheung N, et al. The prevalence of retinal vein occlusion: Pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology 2010;117:313-319.
14. Cheung N, Klein R, Wang JJ, et al. Traditional and novel cardiovascular risk factors for retinal vein occlusion: The multiethnic study of atherosclerosis. Invest Ophthalmol Vis Sci 2008;49:4297-4302.
15. Mitchell P, Smith W, Chang A. Prevalence and associations of retinal vein occlusion in Australia. The Blue Mountains Eye Study. Arch Ophthalmol 1996;114:1243-1247.
16. David R, Zangwill L, Badarna M, Yassur Y. Epidemiology of retinal vein occlusion and its association with glaucoma and increased intraocular pressure. Ophthalmologica 1988;197: 69-74.
17. Lim LL, Cheung N, Wang JJ, et al. Prevalence and risk factors of retinal vein occlusion in an Asian population. Br J Ophthalmol 2008;92:1316-1319.
18. Simsek S, Demirok A, Cinal A, Yasar T. Effect of sex in branch retinal vein occlusion. Eur J Ophthalmol 1998;8:48-51.
19. Zhao J, Sastry SM, Sperduto RD, et al. Arteriovenous crossing patterns in branch retinal vein occlusion. The Eye Disease Case-Control Study Group. Ophthalmology 1993;100: 423-428.
20. Jefferies P, Clemett R, Day T. An anatomical study of retinal arteriovenous crossings and their role in the pathogenesis of retinal branch vein occlusions. Aust N Z J Ophthalmol 1993; 21:213-217.
21. Christoffersen NL, Larsen M. Pathophysiology and hemodynamics of branch retinal vein occlusion. Ophthalmology 1999;106:2054-2062.
22. Staurenghi G, Lonati C, Aschero M, Orzalesi N. Arteriovenous crossing as a risk factor in branch retinal vein occlusion. Am J Ophthalmol 1994;117:211-213.
23. Weinberg D, Dodwell DG, Fern SA. Anatomy of arteriovenous crossings in branch retinal vein occlusion. Am J Ophthalmol 1990;109:298-302.
24. Duker JS, Brown GC. Anterior location of the crossing artery in branch retinal vein obstruction. Arch Ophthalmol 1989; 107:998-1000.
25. Fraenkl SA, Mozaffarieh M, Flammer J. Retinal vein occlusions: The potential impact of a dysregulation of the retinal veins. EPMA J 2010;1:253-261.
26. Donati G, Pournaras CJ, Pizzolato GP, Tsacopoulos M. Decreased nitric oxide production accounts for secondary arteriolar constriction after retinal branch vein occlusion. Invest Ophthalmol Vis Sci 1997;38:1450-1457.
27. Malayan AS, Shakhsuvaryan ML, Grigoryan GL, Melkonyan AK. Retinal vein occlusion in Armenia. Eur J Ophthalmol 1999;9: 196-201.
28. Sofi F, Marcucci R, Fedi S, et al. High lipoprotein (a) levels are associated with an increased risk of retinal vein occlusion. Atherosclerosis 2010;210:278-281.
29. Di Capua M, Coppola A, Albisinni R, et al. Cardiovascular risk factors and outcome in patients with retinal vein occlusion. J Thromb Thrombolysis 2010;30:16-22.
30. Simons BD, Brucker AJ. Branch retinal vein occlusion. Axial length and other risk factors. Retina 1997;17:191-195.
31. Nagra PK, Ho AC, Dugan JD Jr. Lipemia retinalis associated with branch retinal vein occlusion. Am J Ophthalmol 2003; 135:539-542.
32. Turello M, Pasca S, Daminato R, et al. Retinal vein occlusion: Evaluation of "classic" and "emerging" risk factors and treatment. J Thromb Thrombolysis 2010;29:459-464.
33. Hayreh SS, Zimmerman MB, Podhajsky P. Hematologic abnormalities associated with various types of retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 2002;240: 180-196.
34. Lam HD, Lahey JM, Kearney JJ, et al. Young patients with branch retinal vein occlusion: A review of 60 cases. Retina 2010;30:1520-1523.
35. Remky A, Arend O, Jung F, et al. Haemorheology in patients with branch retinal vein occlusion with and without risk factors. Graefes Arch Clin Exp Ophthalmol 1996;234:S8- S12.
36. Banik S, Bhutto HU, Bagga P. Recurrent branch retinal vein occlusion with factor V leiden mutation. Eye 2006; 20:948-949.
37. Demirci FY, Güney DB, Akarçay K, et al. Prevalence of factor V Leiden in patients with retinal vein occlusion. Acta Ophthalmol Scand 1999;77:631-633.
38. Arsène S, Delahousse B, Regina S, et al. Increased prevalence of factor V Leiden in patients with retinal vein occlusion and under 60 years of age. Thromb Haemost 2005;94:101-106.
39. Kalayci D, Gürgey A, Güven D, et al. Factor V Leiden and prothrombin 20210 A mutations in patients with central and branch retinal vein occlusion. Acta Ophthalmol Scand 1999; 77:622-624.
40. Tekeli O, Gürsel E, Buyurgan H. Protein C, protein S and antithrombin III deficiencies in retinal vein occlusion. Acta Ophthalmol Scand 1999;77:628-630.
41. Scott JA, Arnold JJ, Currie JM, et al. No excess of factor V: Q506 genotype but high prevalence of anticardiolipin antibodies without antiendothelial cell antibodies in retinal vein occlusion in young patients. Ophthalmologica 2001;215: 217-221.
42. Hansen L, Kristensen HL, Bek T, Ingerslev J. Markers of thrombophilia in retinal vein thrombosis. Acta Ophthalmol Scand 2000;78:523-526.
43. Abu El-Asrar AM, Abdel Gader AG, Al-Amro S, Al-Momen AK. Hypercoagulable states in patients with retinal venous occlusion. Doc Ophthalmol 1998;95:133-143.
44. Greiner K, Peetz D, Winkgen A, et al. Genetic thrombophilia in patients with retinal vascular occlusion. Int Ophthalmol 1999;23:155-160.
45. Incorvaia C, Parmeggiani F, Costagliola C, et al. The heterozygous 20210 G/A genotype prevalence in patients affected by central and branch retinal vein occlusion: A pilot study. Graefes Arch Clin Exp Ophthalmol 2001;239:251-256.
46. Souied E, Mashhour B, Morel X, et al. Retinal branch vein occlusion associated with macular dystrophy, maternally inherited diabetes, and deafness. Ophthalmic Genet 1997;18: 157-160.
47. Salomon O, Moisseiev J, Vilganski T, et al. Role of five platelet membrane glycoprotein polymorphisms in branch retinal vein occlusion. Blood Coagul Fibrinolysis 2006;17:485-488.
48. Goldberg MF. Retinal vaso-occlusion in sickling hemoglobinopathies. Birth Defects Orig Artic Ser 1976;12:475-515.
49. Miller SA, Bresnick GH. Retinal branch vessel occlusion in acute intermittent porphyria. Ann Ophthalmol 1979;11: 1379-1383.
50. Yau JW, Lee P, Wong TY, et al. Retinal vein occlusion: An approach to diagnosis, systemic risk factors and management. Intern Med J 2008;38:904-910.
51. Satoh S, Itoh C, Nakamura N. A case of frosted branch angiitis associated with retinal vein occlusion as a complication of familial Mediterranean fever. Nihon Ganka Gakkai Zasshi 2010;114:621-628.
52. Alió J, Ruiz-Beltran R, Herrero-Herrero JI, et al. Retinal manifestations of Mediterranean spotted fever. Ophthalmologica 1987;195:31-37.
53. Park KL, Marx JL, Lopez PF, Rao NA. Noninfectious branch retinal vein occlusion in HIV-positive patients. Retina 1997; 17:162-164.
54. Dunn JP, Yamashita A, Kempen JH, Jabs DA. Retinal vascular occlusion in patients infected with human immunodeficiency virus. Retina 2005;25:759-766.
55. Conway MD, Tong P, Olk RJ. Branch retinal artery occlusion (BRAO) combined with branch retinal vein occlusion (BRVO) and optic disc neovascularization associated with HIV and CMV retinitis. Int Ophthalmol 1995-1996;19: 249-252.
56. O'Hearn TM, Fawzi A, Esmaili D, et al. Presumed ocular tuberculosis presenting as a branch retinal vein occlusion in the absence of retinal vasculitis or uveitis. Br J Ophthalmol 2007;91:981-982.
57. Rosenthal G, Schneck M, Lifshitz T. Branch retinal vein occlusion in Churg-Strauss syndrome. Clin Experiment Ophthalmol 2002;30:381-382.
58. De Salvo G, Li Calzi C, Anastasi M, Lodato G. Branch retinal vein occlusion followed by central retinal artery occlusion in Churg-Strauss syndrome: unusual ocular manifestations in allergic granulomatous angiitis. Eur J Ophthalmol 2009;19: 314-317.
59. Janssen MC, den Heijer M, Cruysberg JR, et al. Retinal vein occlusion: A form of venous thrombosis or a complication of atherosclerosis? A meta-analysis of thrombophilic factors. Thromb Haemost 2005;93:1021-1026.
60. Chang PC, Chen WS, Lin HY, et al. Combined central retinal artery and vein occlusion in a patient with systemic lupus erythematosus and anti-phospholipid syndrome. Lupus 2010; 19:206-209.
61. Kimmel AS, McCarthy MJ, Blodi CF, Folk JC. Branch retinal vein occlusion in sarcoidosis. Am J Ophthalmol 1989;107: 561-562.
62. Ohara K, Okubo A, Sasaki H, Kamata K. Branch retinal vein occlusion in a child with ocular sarcoidosis. Am J Ophthalmol 1995;119:806-807.
63. Denis P, Nordmann JP, Laroche L, Saraux H. Branch retinal vein occlusion associated with a sarcoid choroidal granuloma. Am J Ophthalmol 1992;113:333-334.
64. Primo S. Central retinal vein occlusion in a young patient with seropositive syphilis. J Am Optom Assoc 1990;61: 896-902.
65. Yokoi M, Kase M. Retinal vasculitis due to secondary syphilis. Jpn J Ophthalmol 2004;48:65-67.
66. Ozdal PC, Ortaç S, Tasxkintuna I, Firat E. Posterior segment involvement in ocular Behçet's disease. Eur J Ophthalmol 2002;12:424-431.
67. Lee HB, Pulido JS, McCannel CA, Buettner H. Role of inflammation in retinal vein occlusion. Can J Ophthalmol 2007;42:131-133.
68. Conrath J, Hadjadj E, Serratrice J, Ridings B. Branch retinal vein occlusion reveals Takayasu's arteritis. J Fr Ophtalmol 2004;27:162-165.
69. Hirota A, Mishima HK, Kiuchi Y. Incidence of retinal vein occlusion at the Glaucoma Clinic of Hiroshima University. Ophthalmologica 1997;211:288-291.
70. Sherpa D, Shakya S, Shrestha JK. Association of primary glaucomas with retinal vein occlusion. Kathmandu Univ Med J 2008;6:49-54.
71. Sen DK, Sood GC, Dewan R. Developmental glaucoma and branch vein occlusion in thee retina. Indian J Ophthalmol 1971;19:183-184.
72. Richmond PP, Orth DH. Branch retinal vein occlusion associated with optic nerve drusen: A case report. Ophthalmic Surg 1989;20:38-41.
73. Branch Vein Occlusion Study Group. Argon laser scatter photocoagulation for prevention of neovascularization and vitreous hemorrhage in branch vein occlusion. A randomized clinical trial. Arch Ophthalmol 1986;104:34-41.
74. Frucht J, Shapiro A, Merin S. Intraocular pressure in retinal vein occlusion. Br J Ophthalmol 1984;68:26-28.
75. Nicoarǎ; S, Stefaniu M. Ocular refraction and branch of retinal vein occlusion. Oftalmologia 2000;50:39-42.
76. Kir E, Tülin Berk A, Osman Saatci A, et al. Axial length and hyperopia in eyes with retinal vein occlusions. Int Ophthalmol 1997-1998;21:209-211.
77. Majji AB, Janarthanan M, Naduvilath TJ. Significance of refractive status in branch retinal vein occlusion. A case-control study. Retina 1997;17:200-204.
78. Aritürk N, Oge Y, Erkan D, et al. Relation between retinal vein occlusions and axial length. Br J Ophthalmol 1996;80: 633-636.
79. Goldstein M, Leibovitch I, Varssano D, et al. Axial length, refractive error, and keratometry in patients with branch retinal vein occlusion. Eur J Ophthalmol 2004;14:37-39.
80. Park HJ, Nah HJ, Seo MS. Axial length in branch retinal vein occlusion. Korean J Ophthalmol 2000;14:69-73.
81. Timmerman EA, de Lavalette VW, van den Brom HJ. Axial length as a risk factor to branch retinal vein occlusion. Retina 1997;17:196-199.
82. Tsai SC, Chen HY, Chen CY. Relationship between retinal vein occlusion and axial length. Kaohsiung J Med Sci 2003; 19:453-457.
83. Cekiç O, Totan Y, Aydin E, et al. The role of axial length in central and branch retinal vein occlusion. Ophthalmic Surg Lasers 1999;30:523-527.
84. Bandello F, Tavola A, Pierro L, et al. Axial length and refraction in retinal vein occlusions. Ophthalmologica 1998;212:133-135.
85. Matti AI, Lee AW, Chen CS. Concurrent branch retinal vein occlusion and cerebral venous thrombosis from oral contraceptive pill use. Can J Ophthalmol 2010;45: 541-542.
86. Damasceno EF, Neto AM, Damasceno NA, et al. Branch retinal vein occlusion and anabolic steroids abuse in young bodybuilders. Acta Ophthalmol 2009;87:580-581.
87. Meyer CH, Schmidt JC, Rodrigues EB, Mennel S. Risk of retinal vein occlusions in patients treated with rofecoxib (vioxx). Ophthalmologica 2005;219:243-247.
88. Goncalves LL, Farias AQ, Gonçalves PL, et al. Branch retinal vein thrombosis and visual loss probably associated with pegylated interferon therapy of chronic hepatitis C. World J Gastroenterol 2006;12:4602-4603.
89. Nicolò M, Artioli S, La Mattina GC, et al. Branch retinal artery occlusion combined with branch retinal vein occlusion in a patient with hepatitis C treated with interferon and ribavirin. Eur J Ophthalmol 2005;15:811-814.
90. Alghadyan AA. Retinal vein occlusion in Saudi Arabia: Possible role of dehydration. Ann Ophthalmol 1993;25:394-398.
91. O'Mahoney PR, Wong DT, Ray JG. Retinal vein occlusion and traditional risk factors for atherosclerosis. Arch Ophthalmol 2008;126:692-629.
92. Kaderli AA, Kaderli B, Gullulu S, Avci R. Impaired aortic stiffness and pulse wave velocity in patients with branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 2010; 248:369-374.
93. Gumus K, Kadayifcilar S, Eldem B, Ozcebe O. Assessment of the role of thrombin activatable fibrinolysis inhibitor in retinal vein occlusion. Retina 2007;27:578-583.
94. Weger M, Renner W, Steinbrugger I, et al. Role of thrombophilic gene polymorphisms in branch retinal vein occlusion. Ophthalmology 2005;112:1910-1915.
95. Linna T, Ylikorkala A, Kontula K, et al. Prevalence of factor V Leiden in young adults with retinal vein occlusion. Thromb Haemost 1997;77:214-216.
96. Kuhli C, Hattenbach LO, Scharrer I, et al. High prevalence of resistance to APC in young patients with retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 2002;240:163-168.
97. Rehak M, Krcova V, Slavik L, et al. The role of thrombophilia in patients with retinal vein occlusion and no systemic risk factors. Can J Ophthalmol 2010;45:171-175.
98. Saatci AO, Düzovali O, Ozbek Z, et al. Combined central retinal artery and vein occlusion in a child with systemic non-Hodgkin's lymphoma. Int Ophthalmol 1998-1999;22:125-127.
99. The Eye Disease Case-control Study Group. Risk factors for branch retinal vein occlusion. Am J Ophthalmol 1993;116: 286-296.
100. Ehlers JP, Fekrat S. Retinal vein occlusion: Beyond the acute event. Surv Ophthalmol 2011;56:281-299.
101. Kruger-Leite E, Jalkh AE, Avila MP, Trempe CL. Central visual field in patients with retinal branch vein occlusion. Ann Ophthalmol 1985;17:622-623.
102. Birchall CH, Harris GS, Drance SM, Begg IS. Visual field changes in branch retinal 'vein' occlusion. Arch Ophthalmol 1976;94:747-754.
103. Oh J, Oh IK, Huh K. Diurnal variation of the incidence of symptomatic branch retinal vein occlusion. Ophthalmologica 2007;221:251-254.
104. Margolis R, Singh RP, Kaiser PK. Branch retinal vein occlusion: Clinical findings, natural history, and management. Compr Ophthalmol Update 2006;7:265-276.
105. Kimmel AS, Magargal LE, Morrison DL, Robb-Doyle E. Temporal branch retinal vein obstruction masquerading as a retinal arterial macroaneurysm: The Bonet sign. Ann Ophthalmol 1989;21:251-252.
106. Rehak M, Wiedemann P. Retinal vein thrombosis: Pathogenesis and management. J Thromb Haemost 2010;8:1886-1894.
107. Hvarfner C, Andreasson S, Larsson J. Multifocal electroretinography and fluorescein angiography in retinal vein occlusion. Retina 2006;26:292-296.
108. Spaide RF, Lee JK, Klancnik JK Jr, Gross NE. Optical coherence tomography of branch retinal vein occlusion. Retina 2003;23:343-347.
109. Lerche RC, Schaudig U, Scholz F, et al. Structural changes of the retina in retinal vein occlusion - imaging and quantification with optical coherence tomography. Ophthalmic Surg Lasers 2001;32:272-280.
110. Ota M, Tsujikawa A, Murakami T, et al. Association between integrity of foveal photoreceptor layer and visual acuity in branch retinal vein occlusion. Br J Ophthalmol 2007;91: 1644-1649.
111. Ogino K, Murakami T, Tsujikawa A, et al. Characteristics of optical coherence tomographic hyperreflective foci in retinal vein occlusion. Retina 2012;32:77-85.
112. Yamaike N, Kita M, Tsujikawa A, et al. Perimetric sensitivity with the micro perimeter 1 and retinal thickness in patients with branch retinal vein occlusion. Am J Ophthalmol 2007; 143:342-344.
113. Imasawa M, Iijima H, Morimoto T. Perimetric sensitivity and retinal thickness in eyes with macular edema resulting from branch retinal vein occlusion. Am J Ophthalmol 2001;131: 55-60.
114. Bhagat N, Von Hagen S, Zarbin MA. Perimetric sensitivity and retinal thickness in eyes with macular edema resulting from branch retinal vein occlusion. Am J Ophthalmol 2002; 133:428-429.
115. Tranquart F, Arsene S, Giraudeau B, et al. Initial color Doppler findings in retinal vein occlusion. J Clin Ultrasound 2000; 28:28-33.
116. Arséne S, Giraudeau B, Le Lez ML, et al. Follow up by colour Doppler imaging of 102 patients with retinal vein occlusion over 1 year. Br J Ophthalmol 2002;86:1243-1247.
117. Gündüz K, Zengin N, Okudan S, et al. Pattern-reversal electroretinograms and visual evoked potentials in branch retinal vein occlusion. Doc Ophthalmol 1995-1996;91:155-164.
118. Recupero SM, Perdicchi A, Scuderi GL, et al. Visual acuity in central and branch vein retinal occlusion in the presence of macular edema: 1 year of follow-up. Ann Ophthalmol 2006; 38:107-110.
119. Shilling JS, Kohner EM. New vessel formation in retinal branch vein occlusion. Br J Ophthalmol 1976;60:810-815.
120. Parodi MB, Da Pozzo S, Saviano S, Ravalico G. Branch retinal vein occlusion and macroaneurysms. Int Ophthalmol 1997;21:161-164.
121. Cousins SW, Flynn HW Jr, Clarkson JG. Macroaneurysms associated with retinal branch vein occlusion. Am J Ophthalmol 1990;109:567-570.
122. Scimeca G, Magargal LE, Augsburger JJ. Chronic exudative ischemic superior temporal-branch retinal-vein obstruction simulating Coat's disease. Ann Ophthalmol 1986;18:118-120.
123. Singh M, Dhir L, Kon C, Rassam S. Tractional retinal break and rhegmatogenous retinal detachment consequent to branch retinal vein occlusion. Eye 2006;20:1326-1327.
124. Apostolopoulos M, Koutsandrea C, Chatjoulis D, et al. Late complications in branch retinal vein occlusion. Int Ophthalmol 1995-1996;19:281-285.
125. Takahashi M, Hirokawa H, Trempe CL. Vitreous detachment, neovascularization, and vitreous hemorrhage in retinal branch vein occlusion. Nihon Ganka Gakkai Zasshi 1981; 85:731-736.
126. Yamaguchi Y, Otani T, Kishi S. Serous macular detachment in branch retinal vein occlusion. Retina 2006;26:1029-1033.
127. Hayreh SS, Rojas P, Podhajsky P, et al. Ocular neovascularization with retinal vascular occlusion-III. Incidence of ocular neovascularization with retinal vein occlusion. Ophthalmology 1983;90:488-506.
128. Suzuma K, Kita M, Yamana T, et al. Quantitative assessment of macular edema with retinal vein occlusion. Am J Ophthalmol 1998;126:409-416.
129. Noma H, Funatsu H, Sakata K, et al. Macular microcirculation and macular oedema in branch retinal vein occlusion. Br J Ophthalmol 2009;93:630-633.
130. Campochiaro PA, Hafiz G, Shah SM, et al. Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator. Mol Ther 2008;16:791-799.
131. Noma H, Minamoto A, Funatsu H, et al. Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated with macular edema in branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 2006;244:309-315.
132. Rehak M, Hollborn M, Iandiev I, et al. Retinal gene expression and Müller cell responses after branch retinal vein occlusion in the rat. Invest Ophthalmol Vis Sci 2009;50:2359-2367.
133. Kaneda S, Miyazaki D, Sasaki S, et al. Multivariate analyses of inflammatory cytokines in eyes with branch retinal vein occlusion: Relationships to bevacizumab treatment. Invest Ophthalmol Vis Sci 2011;52:2982-2988.
134. Noma H, Funatsu H, Mimura T, Shimada K. Increase of aqueous inflammatory factors in macular edema with branch retinal vein occlusion: A case control study. J Inflamm 2010;7:44.
135. Bringmann A, Reichenbach A,Wiedemann P. Pathomechanisms of cystoid macular edema. Ophthalmic Res 2004;36:241-249.
136. Arnarsson A, Stefánsson E. Laser treatment and the mechanism of edema reduction in branch retinal vein occlusion. Invest Ophthalmol Vis Sci 2000;41:877-879.
137. Finkelstein D. Ischemic macular edema. Recognition and favorable natural history in branch vein occlusion. Arch Ophthalmol 1992;110:1427-1434.
138. Noma H, Funatsu H, Mimura T, et al. Soluble vascular endothelial growth factor receptor-2 and inflammatory factors in macular edema with branch retinal vein occlusion. Am J Ophthalmol 2011;152:669-677.
139. Park SP, Ahn JK, Mun GH. Aqueous vascular endothelial growth factor levels are associated with serous macular detachment secondary to branch retinal vein occlusion. Retina 2010;30:281-286.
140. Lee YJ, Kim JH, Ko MK. Neovascularization in branch retinal vein occlusion combined with arterial insufficiency. Korean J Ophthalmol 2005;19:34-39.
141. Yoo YC, Park KH. Disc hemorrhages in patients with both normal tension glaucoma and branch retinal vein occlusion in different eyes. Korean J Ophthalmol 2007;21:222-227.
142. Chess J, Eichen AL. Rhegmatogenous retinal detachment associated with branch vein occlusion. Ann Ophthalmol. 1989;21:309-311.
143. Ophir A, Trevino A, Martinez MR. Extrafoveal vitreous traction associated with branch retinal vein occlusion. Eur J Ophthalmol 2010;20:733-739.
144. Johnson TM, Vaughn CW, Glaser BM. Branch retinal vein occlusion associated with vitreoretinal traction. Can J Ophthalmol 2006;41:600-602.
145. Takahashi K, Kashima T, Kishi S. Serous macular detachment combined with branch retinal vein occlusion. Nihon Ganka Gakkai Zasshi 2005;109:362-367.
146. Kir E, Saatci AO, Ozbek Z, et al. Retinal breaks and rhegmatogenous retinal detachment in association with branch retinal vein occlusion. Ophthalmic Surg Lasers 1999;30: 285-288.