TAX1BP1, a ubiquitin-binding adaptor protein in innate immunity and beyond

Trends in Biochemical Sciences

Volumn 36, Issue 7, 2011, Pages

  Verstrepen, Lynn ^a,b   Verhelst, Kelly ^a,b   Carpentier, Isabelle ^a,b   Beyaert, Rudi ^a,b  

^a GHENT UNIVERSITY   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

A 20; ADAPTOR PROTEIN; ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT; CELL NUCLEUS RECEPTOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1; TAX1 BINDING PROTEIN 1; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANTIINFLAMMATORY ACTIVITY; ANTIVIRAL ACTIVITY; APOPTOSIS; BINDING SITE; CELL GROWTH; GENE EXPRESSION REGULATION; GROWTH REGULATION; HUMAN; INFLAMMATION; INNATE IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; VIRUS ACTIVATION;

ANIMALS; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INTERFERON REGULATORY FACTOR-3; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASM PROTEINS; NF-KAPPA B; UBIQUITIN; VIRUS DISEASES;

EID: 79959913347     PISSN: 09680004     EISSN: 09680004     Source Type: Journal    
DOI: 10.1016/j.tibs.2011.03.004     Document Type: Review

References (49)

1. Kumar H., et al. Pathogen recognition by the innate immune system. Int. Rev. Immunol. 2011, 30:16-34.
2. O'Neill L.A., Bowie A.G. Sensing and signaling in antiviral innate immunity. Curr. Biol. 2010, 20:R328-R333.
3. Malynn B.A., Ma A. Ubiquitin makes its mark on immune regulation. Immunity 2010, 33:843-852.
4. Dikic I., et al. Ubiquitin-binding domains - from structures to functions. Nat. Rev. Mol. Cell Biol. 2009, 10:659-671.
5. Harhaj E.W., Dixit V. Deubiquitinases in the regulation of NF-κB signaling. Cell Res. 2011, 21:22-39.
6. Verstrepen L., et al. Expression, biological activities and mechanisms of action of A20 (TNFAIP3). Biochem. Pharmacol. 2010, 80:2009-2020.
7. Wertz I.E., et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signaling. Nature 2004, 430:694-699.
8. Boone D.L., et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat. Immunol. 2004, 5:1052-1060.
9. Hitotsumatsu O., et al. The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity 2008, 28:381-390.
10. Bosanac I., et al. Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling. Mol. Cell 2010, 40:548-557.
11. Shembade N., et al. Inhibition of NF-κB signaling by A20 through disruption of ubiquitin enzyme complexes. Science 2010, 327:1135-1139.
12. Parvatiyar K., et al. TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1/IKKi kinases. J. Biol. Chem. 2010, 285:14999-15009.
13. Kayagaki N., et al. DUBA: a deubiquitinase that regulates type I interferon production. Science 2007, 318:1628-1632.
14. Shembade N., et al. The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat. Immunol. 2008, 9:254-262.
15. Shembade N., et al. The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signaling. EMBO J. 2009, 28:513-522.
16. Verstrepen L., et al. ABINs: A20 binding inhibitors of NF-κB and apoptosis signaling. Biochem. Pharmacol. 2009, 78:105-114.
17. Wagner S., et al. Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins. Oncogene 2008, 27:3739-3745.
18. Iha H., et al. Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation. EMBO J. 2008, 27:629-641.
19. Shembade N., et al. Essential role for TAX1BP1 in the termination of TNFα-, IL-1- and LPS-mediated NF-κB and JNK signaling. EMBO J. 2007, 26:3910-3922.
20. Chin K.T., et al. Human T-cell leukemia virus oncoprotein Tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1. Cancer Res. 2007, 67:1072-1081.
21. Wu K., et al. Protein profile of Tax-associated complexes. J. Biol. Chem. 2004, 279:495-508.
22. Gachon F., et al. CREB-2, a cellular CRE-dependent transcription repressor, functions in association with Tax as an activator of the human T-cell leukemia virus type 1 promoter. J. Virol. 1998, 72:8332-8337.
23. De Valck D., et al. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene 1999, 18:4182-4190.
24. Ling L., Goeddel D.V. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:9567-9572.
25. Nagaraja G.M., Kandpal R.P. Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. Biochem. Biophys. Res. Commun. 2004, 313:654-665.
26. L'Esperance S., et al. Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors. Int. J. Oncol. 2006, 29:5-24.
27. Nguyen H., et al. Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes. J. Virol. 2006, 354:58-68.
28. c receptor ρ1 subunit. Biochem. J. 2007, 401:429-436.
29. Morriswood B., et al. T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signaling and cell adhesion. J. Cell. Sci. 2007, 120:2574-2585.
30. Gurung R., et al. Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. J. Biol. Chem. 2003, 278:11376-11385.
31. Sudol M., et al. Characterization of a novel protein-binding module - the WW domain. FEBS Lett. 1995, 369:67-71.
32. Boxus M., et al. The HTLV-I Tax interactome. Retrovirology 2008, 5:76.
33. Iha H., et al. Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism: mitotic checkpoint abrogation and NF-κB activation. AIDS Res. Hum. Retroviruses 2000, 16:1633-1638.
34. Gohda J., et al. HTLV-1 Tax-induced NFκB activation is independent of Lys-63-linked-type polyubquitination. Biochem. Biophys. Res. Commun. 2007, 357:225-230.
35. Shembade N., et al. The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-κB activation. J. Virol. 2007, 81:13735-13742.
36. Lee E.G., et al. Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice. Science 2000, 289:2350-2354.
37. Bohgaki M., et al. Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain. Biochim. Biophys. Acta 2008, 1783:826-837.
38. Zeng W., et al. Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. Mol. Cell 2009, 36:315-325.
39. You F., et al. PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nat. Immunol. 2009, 10:1300-1308.
40. Journo C., et al. NRP/optineurin cooperates with TAX1BP1 to potentiate the activation of NF-κB by human T-lymphotropic virus type 1 Tax protein. PLoS Pathog. 2009, 5:e1000521.
41. Mankouri J., et al. Optineurin negatively regulates the induction of IFNβ in response to RNA virus infection. PLoS Pathog. 2010, 6:e1000778.
42. Jin Z., et al. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 2009, 137:721-735.
43. He K.L., Ting A.T. A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. Mol. Cell Biol. 2002, 22:6034-6045.
44. Won M., et al. Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation. Cell Death Differ. 2010, 17:1830-1841.
45. Matsusaka T., Pines J. Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells. J. Cell. Biol. 2004, 166:507-516.
46. Tanaka Y., et al. Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma. J. Hepatol. 2008, 49:746-757.
47. Wang X., et al. TAX1BP1 interacts with papillomavirus E2 and regulates E2-dependent transcription and stability. J. Virol. 2009, 83:2274-2284.
48. Kim J.H., et al. CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Mol. Cell 2003, 12:1537-1549.
49. Vereecke L., et al. The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology. Trends Immunol. 2009, 30:383-391.