TREM-1 amplifies corneal inflammation after Pseudomonas aeruginosa infection by modulating toll-like receptor signaling and Th1/Th2-type immune responses

Infection and Immunity

Volumn 79, Issue 7, 2011, Pages 2709-2716

  Wu, Minhao ^a,b,c   Peng, Anping ^a,b   Sun, Mingxia ^c   Deng, Qiuchan ^a,b   Hazlett, Linda D ^c   Yuan, Jin ^d   Liu, Xialin ^d   Gao, Qianying ^d   Feng, Lianqiang ^a,b   He, Junfang ^a,b   Zhang, Ping ^a,b   Huang, Xi ^a,b,c,d  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 2; HYBRID PROTEIN; INTERLEUKIN 1 RECEPTOR; MESSENGER RNA; TOLL LIKE RECEPTOR; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORNEA PERFORATION; CYTOKINE PRODUCTION; DISEASE SEVERITY; EYE; FEMALE; HUMAN; IMMUNE RESPONSE; KERATITIS; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL;

ADULT; AGED; ANIMALS; ANTIBODIES; BETA-DEFENSINS; CORNEA; CYTOKINES; EYE INFECTIONS, BACTERIAL; FEMALE; HUMANS; KERATITIS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MIDDLE AGED; NEUTROPHIL INFILTRATION; NEUTROPHILS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-1; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS; TOLL-LIKE RECEPTORS;

EID: 79959429685     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00144-11     Document Type: Article

References (44)

1. Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499-511.
2. Biragyn, A., et al. 2008. Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. J. Leukoc. Biol. 83:998-1008.
3. Biragyn, A., et al. 2002. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 298:1025-1029.
4. Bouchon, A., J. Dietrich, and M. Colonna. 2000. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J. Immunol. 164:4991-4995.
5. Bouchon, A., F. Facchetti, M. A. Weigand, and M. Colonna. 2001. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410:1103-1107.
6. Brint, E. K., et al. 2004. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat. Immunol. 5:373-379.
7. Cohen, J. 2001. TREM-1 in sepsis. Lancet 358:776-778.
8. Colonna, M. 2003. TREMs in the immune system and beyond. Nat. Rev. Immunol. 3:445-453.
9. Cowell, B. A., et al. 1998. An ocular strain of Pseudomonas aeruginosa is inflammatory but not virulent in the scarified mouse model. Exp. Eye Res. 67:347-356.
10. Engel, L. S., et al. 1995. Effectiveness of specific antibiotic/steroid combinations for therapy of experimental Pseudomonas aeruginosa keratitis. Curr. Eye Res. 14:229-234.
11. Ferat-Osorio, E., et al. 2008. The increased expression of TREM-1 on monocytes is associated with infectious and noninfectious inflammatory processes. J. Surg. Res. 150:110-117.
12. Hazlett, L. D. 2004. Corneal response to Pseudomonas aeruginosa infection. Prog. Retin. Eye Res. 23:1-30.
13. Hazlett, L. D. 2002. Pathogenic mechanisms of P. aeruginosa keratitis: a review of the role of T cells, Langerhans cells, PMN, and cytokines. DNA Cell Biol. 21:383-390.
14. Hazlett, L. D. 2005. Role of innate and adaptive immunity in the pathogenesis of keratitis. Ocul. Immunol. Inflamm. 13:133-138.
15. Hazlett, L. D., S. McClellan, B. Kwon, and R. Barrett. 2000. Increased severity of Pseudomonas aeruginosa corneal infection in strains of mice designated as Th1 versus Th2 responsive. Invest. Ophthalmol. Vis. Sci. 41: 805-810.
16. Hazlett, L. D., X. L. Rudner, S. A. McClellan, R. P. Barrett, and S. Lighvani. 2002. Role of IL-12 and IFN-gamma in Pseudomonas aeruginosa corneal infection. Invest. Ophthalmol. Vis. Sci. 43:419-424.
17. Hazlett, L. D., R. Zelt, C. Cramer, and R. S. Berk. 1985. Pseudomonas aeruginosa induced ocular infection. A histological comparison of two bacterial strains of different virulence. Ophthalmic Res. 17:289-296.
18. Huang, X., W. Du, R. P. Barrett, and L. D. Hazlett. 2007. ST2 is essential for Th2 responsiveness and resistance to Pseudomonas aeruginosa keratitis. Invest. Ophthalmol. Vis. Sci. 48:4626-4633.
19. Huang, X., L. D. Hazlett, W. Du, and R. P. Barrett. 2006. SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling. J. Immunol. 177:548-556.
20. Kernacki, K. A., R. P. Barrett, J. A. Hobden, and L. D. Hazlett. 2000. Macrophage inflammatory protein-2 is a mediator of polymorphonuclear neutrophil influx in ocular bacterial infection. J. Immunol. 164:1037-1045.
21. Kernacki, K. A., R. P. Barrett, S. McClellan, and L. D. Hazlett. 2001. MIP-1alpha regulates CD4+ T cell chemotaxis and indirectly enhances PMN persistence in Pseudomonas aeruginosa corneal infection. J. Leukoc. Biol. 70:911-919.
22. Kernacki, K. A., D. J. Goebel, M. S. Poosch, and L. D. Hazlett. 1998. Early cytokine and chemokine gene expression during Pseudomonas aeruginosa corneal infection in mice. Infect. Immun. 66:376-379.
23. Knapp, S., et al. 2004. Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia. J. Immunol. 173:7131-7134.
24. Kwon, B., and L. D. Hazlett. 1997. Association of CD4+ T cell-dependent keratitis with genetic susceptibility to Pseudomonas aeruginosa ocular infection. J. Immunol. 159:6283-6290.
25. Lagler, H., et al. 2009. TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia. J. Immunol. 183:2027-2036.
26. Liew, F. Y., H. Liu, and D. Xu. 2005. A novel negative regulator for IL-1 receptor and Toll-like receptor 4. Immunol. Lett. 96:27-31.
27. McClellan, S. A., X. Huang, R. P. Barrett, N. van Rooijen, and L. D. Hazlett. 2003. Macrophages restrict Pseudomonas aeruginosa growth, regulate polymorphonuclear neutrophil influx, and balance pro-and anti-inflammatory cytokines in BALB/c mice. J. Immunol. 170:5219-5227.
28. Murakami, Y., et al. 2006. Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals. Arthritis Rheum. 54:455-462.
29. Murakami, Y., H. Kohsaka, H. Kitasato, and T. Akahoshi. 2007. Lipopolysaccharide-induced up-regulation of triggering receptor expressed on myeloid cells-1 expression on macrophages is regulated by endogenous prostaglandin e2. J. Immunol. 178:1144-1150.
30. O'Neill, L. A., et al. 2003. Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors. J. Endotoxin Res. 9:55-59.
31. Qin, J., Y. Qian, J. Yao, C. Grace, and X. Li. 2005. SIGIRR inhibits interleukin-1 receptor-and Toll-like receptor 4-mediated signaling through different mechanisms. J. Biol. Chem. 280:25233-25241.
32. Radsak, M. P., H. R. Salih, H. G. Rammensee, and H. Schild. 2004. Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival. J. Immunol. 172:4956-4963.
33. Schenk, M., A. Bouchon, F. Seibold, and C. Mueller. 2007. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J. Clin. Invest. 117:3097-3106.
34. Schulze-Koops, H., and J. R. Kalden. 2001. The balance of Th1/Th2 cytokines in rheumatoid arthritis. Best Pract. Res. Clin. Rheumatol. 15:677-691.
35. Thakur, A., R. P. Barrett, S. McClellan, and L. D. Hazlett. 2004. Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice. Curr. Eye Res. 29:225-233.
36. Verstak, B., et al. 2009. MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2-and TLR4-mediated NF-kappaB proinflammatory responses. J. Biol. Chem. 284:24192-24203
37. Wald, D., et al. 2003. SIGIRR, a negative regulator of Toll-like receptorinterleukin 1 receptor signaling. Nat. Immunol. 4:920-927.
38. Wang, J., Y. Hu, W. W. Deng, and B. Sun. 2009. Negative regulation of Toll-like receptor signaling pathway. Microbes Infect. 11:321-327.
39. Wilhelmus, K. R. 1987. Review of clinical experience with microbial keratitis associated with contact lenses. CLAO J. 13:211-214.
40. Williams, R. N., C. A. Paterson, K. E. Eakins, and P. Bhattacherjee. 1982. Quantification of ocular inflammation: evaluation of polymorphonuclear leucocyte infiltration by measuring myeloperoxidase activity. Curr. Eye Res. 2:465-470.
41. Wu, M., S. A. McClellan, R. P. Barrett, and L. D. Hazlett. 2009. Betadefensin-2 promotes resistance against infection with P. aeruginosa. J. Immunol. 182:1609-1616.
42. Wu, M., S. A. McClellan, R. P. Barrett, Y. Zhang, and L. D. Hazlett. 2009. Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis. J. Immunol. 183:8054-8060.
43. Youssef, R. E., et al. 2009. The role of Toll-like receptors (TLR-2 and -4) and triggering receptor expressed on myeloid cells 1 (TREM-1) in human term and preterm labor. Reprod. Sci. 16:843-856.
44. Zheng, H., et al. 2010. MYD88-dependent and -independent activation of TREM-1 via specific TLR ligands. Eur. J. Immunol. 40:162-171.