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1
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42649092878
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Cardiac allograft vasculopathy: Recent developments
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This review summarizes new insights into the pathogenesis, detection and treatment of CAV
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Schmauss D, Weis M. Cardiac allograft vasculopathy: recent developments. Circulation 2008; 117:2131-2141. This review summarizes new insights into the pathogenesis, detection and treatment of CAV.
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(2008)
Circulation
, vol.117
, pp. 2131-2141
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Schmauss, D.1
Weis, M.2
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2
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0028210184
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Peritransplant injury to the myocardium associated with the development of accelerated arteriosclerosis in heart transplant recipients
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Gaudin P, Rayburn B, Hutchins G, et al. Peritransplant injury to the myocardium associated with the development of accelerated arteriosclerosis in heart transplant recipients. Am J Surg Pathol 1994; 18:338-346.
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(1994)
Am J Surg Pathol
, vol.18
, pp. 338-346
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Gaudin, P.1
Rayburn, B.2
Hutchins, G.3
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3
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58149500135
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Toll-like receptor signaling: A critical modulator of cell survival and ischemic injury in theheart
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This is an excellent in-depth article on TLRs and their influence on the heart
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Chao W. Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in theheart. Am J Physiol Heart Circ Physiol 2009;296:H1-H12. This is an excellent in-depth article on TLRs and their influence on the heart.
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(2009)
Am J Physiol Heart Circ Physiol
, vol.296
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Chao, W.1
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4
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73349125273
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329: TLR2 signaling blocks regulatory T cell suppression leading to immune activation following cardiac allotransplantation
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Ramachandran S, Goers T, Liu W, et al. 329: TLR2 signaling blocks regulatory T cell suppression leading to immune activation following cardiac allotransplantation. J Heart Lung Transplant 2006; 25:S157-S1157.
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(2006)
J Heart Lung Transplant
, vol.25
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Ramachandran, S.1
Goers, T.2
Liu, W.3
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5
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1842477469
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MRNA is an endogenous ligand for Toll-like receptor 3
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Karikó K, Ni H, Capodici J, et al. mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 2004; 279:12542-12550.
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(2004)
J Biol Chem
, vol.279
, pp. 12542-12550
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Karikó, K.1
Ni, H.2
Capodici, J.3
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6
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33846192038
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Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury
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Hardarson H, Baker J, Yang Z, et al. Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. Am J Physiol Heart Circ Physiol 2007; 292:H251-H258.
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(2007)
Am J Physiol Heart Circ Physiol
, vol.292
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Hardarson, H.1
Baker, J.2
Yang, Z.3
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7
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49649085838
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Mechanisms underlying blockade of allograft acceptance by TLR ligands
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This study demonstrates that TLR activation interferes with tolerance to cardiac allografts by modulating the suppressive activity of Tregs
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Porrett P, Yuan X, LaRosa D, et al. Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol 2008; 181:1692-1699. This study demonstrates that TLR activation interferes with tolerance to cardiac allografts by modulating the suppressive activity of Tregs.
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(2008)
J Immunol
, vol.181
, pp. 1692-1699
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Porrett, P.1
Yuan, X.2
Larosa, D.3
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8
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38149062127
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Activation of the innate immune system by the endogenous ligand hyaluronan
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Shirali A, Goldstein D. Activation of the innate immune system by the endogenous ligand hyaluronan. Curr Opin Organ Transplant 2008; 13:20-25.
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(2008)
Curr Opin Organ Transplant
, vol.13
, pp. 20-25
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Shirali, A.1
Goldstein, D.2
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9
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49249116400
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Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion
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This study provides evidence that ischemia/reperfusion leads to endogenous signaling that, in TLR-dependent fashion, creates an inflammatory milieu
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Zou N, Ao L, Cleveland J, et al. Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion. Am J Physiol Heart Circ Physiol 2008; 294:H2805-H2813. This study provides evidence that ischemia/reperfusion leads to endogenous signaling that, in TLR-dependent fashion, creates an inflammatory milieu.
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(2008)
Am J Physiol Heart Circ Physiol
, vol.294
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Zou, N.1
Ao, L.2
Cleveland, J.3
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10
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51649111202
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High-mobility group box-1 in ischemiareperfusion injury of the heart
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Andrassy M, Volz H, Igwe JC, et al. High-mobility group box-1 in ischemiareperfusion injury of the heart. Circulation 2008; 117:3216-3226.
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(2008)
Circulation
, vol.117
, pp. 3216-3226
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Andrassy, M.1
Volz, H.2
Igwe, J.C.3
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11
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42949110583
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Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia
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A study demonstrating that the cytokine release caused by TLR4 has immediate effects on the function of reperfused myocardium
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Cha J, Wang Z, Ao L, et al. Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia. Ann Thorac Surg 2008; 85:1678-1685. A study demonstrating that the cytokine release caused by TLR4 has immediate effects on the function of reperfused myocardium.
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(2008)
Ann Thorac Surg
, vol.85
, pp. 1678-1685
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Cha, J.1
Wang, Z.2
Ao, L.3
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12
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53249153465
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Sequential expression of TLR4 and its effects on the myocardium of rats with myocardial ischemia-reperfusion injury
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Yang J, Yang J, Ding J, et al. Sequential expression of TLR4 and its effects on the myocardium of rats with myocardial ischemia-reperfusion injury. Inflammation 2008; 31:304-312.
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(2008)
Inflammation
, vol.31
, pp. 304-312
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Yang, J.1
Yang, J.2
Ding, J.3
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13
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38449109334
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Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion
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Kaczorowski D, Nakao A, Mollen K, et al. Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion. Transplantation 2007; 84:1279-1287.
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(2007)
Transplantation
, vol.84
, pp. 1279-1287
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Kaczorowski, D.1
Nakao, A.2
Mollen, K.3
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14
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8644221278
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Evidence for a role of toll-like receptor 4 in development of chronic allograft rejection after cardiac transplantation
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Methe H, Zimmer E, Grimm C, et al. Evidence for a role of toll-like receptor 4 in development of chronic allograft rejection after cardiac transplantation. Transplantation 2004; 78:1324-1331.
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(2004)
Transplantation
, vol.78
, pp. 1324-1331
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Methe, H.1
Zimmer, E.2
Grimm, C.3
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15
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33748490733
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TLR engagement prevents transplantation tolerance
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Chen L, Wang T, Zhou P, et al. TLR engagement prevents transplantation tolerance. Am J Transplant 2006; 6:2282-2291.
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(2006)
Am J Transplant
, vol.6
, pp. 2282-2291
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Chen, L.1
Wang, T.2
Zhou, P.3
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16
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59049094662
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Adaptive immune features of natural killer cells
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This paper describes one of two recent studies demonstrating the ability of NK cells to acquire a memory phenotype
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Sun JC, Beilke JN, Lanier LL. Adaptive immune features of natural killer cells. Nature 2009; 457:557-561. This paper describes one of two recent studies demonstrating the ability of NK cells to acquire a memory phenotype.
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(2009)
Nature
, vol.457
, pp. 557-561
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Sun, J.C.1
Beilke, J.N.2
Lanier, L.L.3
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17
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60549091350
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Cytokine-induced memory-like natural killer cells
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This paper describes the second recent study demonstrating the ability of NK cells to acquire a memory phenotype
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Cooper M, Elliott J, Keyel P, et al. Cytokine-induced memory-like natural killer cells. Proc Natl Acad Sci U S A 2009; 106:1915-1919. This paper describes the second recent study demonstrating the ability of NK cells to acquire a memory phenotype.
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(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 1915-1919
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Cooper, M.1
Elliott, J.2
Keyel, P.3
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18
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50949129489
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The Innate NK Cells, Allograft Rejection, and a Key Role for IL-15
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In this experiment, it was shown that NK cells are capable of rejecting a skin transplant in a recipient that lacks an adaptive immune system
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Kroemer A, Xiao X, Degauque N, et al. The Innate NK Cells, Allograft Rejection, and a Key Role for IL-15. J Immunol 2008; 180:7818-7826. In this experiment, it was shown that NK cells are capable of rejecting a skin transplant in a recipient that lacks an adaptive immune system.
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(2008)
J Immunol
, vol.180
, pp. 7818-7826
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Kroemer, A.1
Xiao, X.2
Degauque, N.3
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19
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0012465040
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Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice
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Szot G, Zhou P, Rulifson I, et al. Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice. Am J Transplant 2001; 1: 38-46.
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(2001)
Am J Transplant
, vol.1
, pp. 38-46
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Szot, G.1
Zhou, P.2
Rulifson, I.3
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20
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33644881883
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Role of natural killer cell subsets in cardiac allograft rejection
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McNerney M, Lee K, Zhou P, et al. Role of natural killer cell subsets in cardiac allograft rejection. Am J Transplant 2006; 6:505-513.
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(2006)
Am J Transplant
, vol.6
, pp. 505-513
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McNerney, M.1
Lee, K.2
Zhou, P.3
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21
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38449113206
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The activating immunoreceptor NKG2D and its ligands are involved in allograft transplant rejection
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Kim J, Chang C, Hayden T, et al. The activating immunoreceptor NKG2D and its ligands are involved in allograft transplant rejection. J Immunol 2007; 179:6416-6420.
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(2007)
J Immunol
, vol.179
, pp. 6416-6420
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Kim, J.1
Chang, C.2
Hayden, T.3
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22
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33747614560
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NK-cell-dependent acute xenograft rejection in the mouse heart-to-rat model
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Chen D, Weber M, Lechler R, et al. NK-cell-dependent acute xenograft rejection in the mouse heart-to-rat model. Xenotransplantation 2006; 13:408-414.
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(2006)
Xenotransplantation
, vol.13
, pp. 408-414
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Chen, D.1
Weber, M.2
Lechler, R.3
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23
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73349103588
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422: Natural killer cells deplete from peripheral blood and increase in myocardial tissue during acute rejection following heart transplantation
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Fildes J, Bishop P, Mitchell J, et al. 422: natural killer cells deplete from peripheral blood and increase in myocardial tissue during acute rejection following heart transplantation. J Heart Lung Transplant 2008; 27:S212-S213.
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(2008)
J Heart Lung Transplant
, vol.27
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Fildes, J.1
Bishop, P.2
Mitchell, J.3
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24
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38949154519
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Natural killer cells in peripheral blood and lung tissue are associated with chronic rejection after lung transplantation
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A report that NK cells migrate from peripheral blood to the lung during pulmonary allograft rejection. There is preliminary evidence in [23] that a similar process occurs in cardiac allografts
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Fildes J, Yonan N, Tunstall K, et al. Natural killer cells in peripheral blood and lung tissue are associated with chronic rejection after lung transplantation. J Heart Lung Transplant 2008; 27:203-207. A report that NK cells migrate from peripheral blood to the lung during pulmonary allograft rejection. There is preliminary evidence in [23] that a similar process occurs in cardiac allografts.
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(2008)
J Heart Lung Transplant
, vol.27
, pp. 203-207
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Fildes, J.1
Yonan, N.2
Tunstall, K.3
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25
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23844476052
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NK cells can trigger allograft vasculopathy: The role of hybrid resistance in solid organ allografts
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Uehara S, Chase C, Kitchens W, et al. NK cells can trigger allograft vasculopathy: the role of hybrid resistance in solid organ allografts. J Immunol 2005; 175:3424-3430.
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(2005)
J Immunol
, vol.175
, pp. 3424-3430
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Uehara, S.1
Chase, C.2
Kitchens, W.3
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26
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0842278645
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Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor
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Hamerman J, Ogasawara K, Lanier L. Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol 2004; 172:2001-2005.
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(2004)
J Immunol
, vol.172
, pp. 2001-2005
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Hamerman, J.1
Ogasawara, K.2
Lanier, L.3
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27
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58149190441
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Interaction of monocytes with NK cells upon Toll-like receptor-induced expression of the NKG2D ligand MICA
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Kloss M, Decker P, Baltz K, et al. Interaction of monocytes with NK cells upon Toll-like receptor-induced expression of the NKG2D ligand MICA. J Immunol 2008; 181:6711-6719.
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(2008)
J Immunol
, vol.181
, pp. 6711-6719
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Kloss, M.1
Decker, P.2
Baltz, K.3
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28
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58149229634
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A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells
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Hochweller K, Striegler J, Hämmerling G, Garbi N. A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur J Immunol 2008; 38: 2776-2783.
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(2008)
Eur J Immunol
, vol.38
, pp. 2776-2783
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Hochweller, K.1
Striegler, J.2
Hämmerling, G.3
Garbi, N.4
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29
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0033610274
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Complement deposition in early cardiac transplant biopsies is associated with ischemic injury and subsequent rejection episodes
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Baldwin W, Samaniego-Picota M, Kasper E, et al. Complement deposition in early cardiac transplant biopsies is associated with ischemic injury and subsequent rejection episodes. Transplantation 1999; 68:894-900.
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(1999)
Transplantation
, vol.68
, pp. 894-900
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Baldwin, W.1
Samaniego-Picota, M.2
Kasper, E.3
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30
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20844452888
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Capillary deposition of the complement fragment C4d in cardiac allograft biopsies is associated with allograft vasculopathy
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Poelzl G, Ullrich R, Huber A, et al. Capillary deposition of the complement fragment C4d in cardiac allograft biopsies is associated with allograft vasculopathy. Transpl Int 2005; 18:313-317.
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(2005)
Transpl Int
, vol.18
, pp. 313-317
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Poelzl, G.1
Ullrich, R.2
Huber, A.3
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31
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58149159904
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Complement gene expression in human cardiac allograft biopsies as a correlate of histologic grade of injury
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Keslar K, Rodriguez E, Tan C, et al. Complement gene expression in human cardiac allograft biopsies as a correlate of histologic grade of injury. Transplantation 2008; 86:1319-1321.
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(2008)
Transplantation
, vol.86
, pp. 1319-1321
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Keslar, K.1
Rodriguez, E.2
Tan, C.3
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32
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57149103158
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Donor deficiency of decayaccelerating factor accelerates murine T cell-mediated cardiac allograft rejection
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Pavlov V, Raedler H, Yuan S, Leisman S, et al. Donor deficiency of decayaccelerating factor accelerates murine T cell-mediated cardiac allograft rejection. J Immunol 2008; 181:4580-4589.
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(2008)
J Immunol
, vol.181
, pp. 4580-4589
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Pavlov, V.1
Raedler, H.2
Yuan, S.3
Leisman, S.4
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33
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58149345075
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Posttransplant ischemia-reperfusion injury in transplanted heart is prevented by a minibody to the fifth component of complement
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Here, it is demonstrated that interference with complement deposition can ameliorate the inflammatory response and the cellular injury associated with ischemia/reperfusion
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Ferraresso M, Macor P, Valente M, et al. Posttransplant ischemia-reperfusion injury in transplanted heart is prevented by a minibody to the fifth component of complement. Transplantation 2008; 86:1445-1451. Here, it is demonstrated that interference with complement deposition can ameliorate the inflammatory response and the cellular injury associated with ischemia/reperfusion.
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(2008)
Transplantation
, vol.86
, pp. 1445-1451
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Ferraresso, M.1
MacOr, P.2
Valente, M.3
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34
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57049136118
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Mannose-binding lectin deficiency offers protection from acute graft rejection after heart transplantation
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Fildes J, Shaw S, Walker A, et al. Mannose-binding lectin deficiency offers protection from acute graft rejection after heart transplantation. J Heart Lung Transplant 2008; 27:1353-1356.
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(2008)
J Heart Lung Transplant
, vol.27
, pp. 1353-1356
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Fildes, J.1
Shaw, S.2
Walker, A.3
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