Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity

Journal of Biological Chemistry

Volumn 288, Issue 17, 2013, Pages 12090-12101

  Zhang, Yinghui ^a   Wang, Ningning ^a   Raab, Ronald W ^d   McKown, Robert L ^d   Irwin, Jacob A ^c   Kwon, Inchan ^c   Van Kuppevelt, Toin H ^e   Laurie, Gordon W ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c University of Virginia   (United States)

^d James Madison University   (United States)

^e RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPATHIC; CELL-SURFACE HEPARAN; CHONDROITIN SULFATES; CORE PROTEINS; DOCKING SITES; DYNAMIC PROCESS; GLYCOSAMINOGLYCANS; PROTEOGLYCANS;

AMINO ACIDS; CELL MEMBRANES; HYDROPHOBICITY;

BINDING SITES;

ALANINE; ASPARTIC ACID; CHONDROITIN SULFATE; GLUTAMIC ACID; GLYCINE; GLYCOPROTEIN; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; HEPARANASE; LACRITIN; LEUCINE; SYNDECAN 1; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SULFATION;

AMINO ACID SUBSTITUTION; CHONDROITIN SULFATES; GLUCURONIDASE; GLYCOPROTEINS; HEK293 CELLS; HEPARITIN SULFATE; HUMANS; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SYNDECAN-1;

EID: 84876934292     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.422717     Document Type: Article

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