A role for syndecan-1 in coupling fascin spike formation by thrombospondin-1

Journal of Cell Biology

Volumn 152, Issue 6, 2001, Pages 1169-1182

  Adams, Josephine C ^a   Kureishy, Nina ^a   Taylor, Amanda L ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Actin; Cell adhesion; Extracellular matrix; Proteoglycan; Protrusions

Indexed keywords

ACTIN; CELL SURFACE RECEPTOR; FASCIN; GLYCOSAMINOGLYCAN; SYNDECAN 1; THROMBOSPONDIN 1; UNCLASSIFIED DRUG; VINCULIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MOTILITY; CELL SPREADING; CELL STRAIN COS7; CONTROLLED STUDY; CYTOSKELETON; DELETION MUTANT; EXTRACELLULAR MATRIX; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC TRANSFECTION; IMMUNE RESPONSE; MOUSE; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; WOUND HEALING;

ACTINS; ANIMALS; ANTIGENS, CD; ANTIGENS, CD36; ANTIGENS, CD47; CARRIER PROTEINS; CELL ADHESION; CELL LINE; CELL MEMBRANE; CELL MOVEMENT; CELL SEPARATION; CELL SURFACE EXTENSIONS; CELLS, CULTURED; CHELATING AGENTS; CULTURE MEDIA, SERUM-FREE; CYTOSKELETON; EDETIC ACID; FLOW CYTOMETRY; GLYCOSAMINOGLYCANS; HUMANS; IMMUNOBLOTTING; INTEGRINS; MEMBRANE GLYCOPROTEINS; MICE; MICROFILAMENT PROTEINS; MICROSCOPY, FLUORESCENCE; PROTEOGLYCANS; RECOMBINANT FUSION PROTEINS; SYNDECAN-1; SYNDECANS; THROMBOSPONDIN 1; TRANSFECTION; VINCULIN;

ANIMALIA;

EID: 0035911954     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.6.1169     Document Type: Article

References (79)

1. Formation of stable microspikes containing actin and the 55 kDa actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: Implications for the anti-adhesive activities of thrombospondin-1
2. Thrombospondin-1
3. Characterization of cell-matrix adhesion requirements for the formation of fascin microspikes
4. Diverse mechanisms for cell attachment to platelet thrombospondin
5. Cell-type specific adhesive interactions of skeletal myoblasts with thrombospondin-1
6. Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42
7. Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1
8. Cell-matrix adhesions differentially regulate fascin phosphorylation
9. Analysis of fibronectin receptor function with monoclonal antibodies: Roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization
10. Cellular attachment to thrombospondin: Cooperative interactions between receptor systems
11. Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding
12. Monoclonal antibodies that recognize different membrane proteins that are deficient in Rh-null human erythrocytes. One group of antibodies reacts with a variety of cells and tissues whereas the other group is erythroid-specific
13. Functions of cell surface heparan sulfate proteoglycans
14. Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin-1
15. Integrin-associated protein: A 50 kD plasma-membrane antigen physically and functionally associated with integrins
16. Syndecan-1 expressed in Schwann cells causes morphological transformation and cytoskeletal reorganization and associates with actin during cell spreading
17. Aggregation-induced association of syndecan-1 with microfilaments mediated by the cytoplasmic domain
18. The cytoplasmic domain of syndecan-1 is required for cytoskeleton association but not detergent insolubility
19. Binding and degradation of thrombospondin-1 mediated through heparan sulphate proteoglycans and low-density-lipoprotein receptor-related protein: Localization of the functional activity to the trimeric N-terminal heparin-binding region of thrombospondin-1
20. Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor
21. Inhibition of cell adhesion by anti-adhesive molecules
22. Integrins and signal transduction pathways: The road taken
23. Colocalization of thrombospondin and syndecan during murine development
24. Syndecan-4 and integrins: Combinatorial signaling in cell adhesion
25. Identification and location on syndecan-1 core protein of the epitopes of B-B2 and B-B4 monoclonal antibodies
26. Cell-adhesive responses to tenascin-C splice variants involve formation of fascin microspikes
27. Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase
28. Cell adhesion to a motif shared by the malaria circumsporozoite protein and thrombospondin is mediated by its glycosaminoglycan-binding region and not by CSVTCG
29. 3 function through integrin-associated protein
30. A tumor-suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin
31. Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1
32. Syntenin, a PDZ protein that binds syndecan cytoplasmic domains
33. Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesion
34. Heparin-binding peptides from the type I repeats of thrombospondin. Structural requirements for heparin binding and promotion of melanoma cell adhesion and chemotaxis
35. Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: Assessment of selectivity, heterogeneity and the participation of core proteins in binding
36. Monoclonal antibodies specific for human monocytes, granulocytes and endothelium
37. Cell adhesion: Old and new questions
38. Heparan sulphate proteoglycans from mouse mammary epithelial cells: Localization on the cell surface with a monoclonal antibody
39. Chinese hamster ovary cell adhesion to human platelet thrombospondin is dependent on cell surface heparan sulfate proteoglycan
40. Adhesion molecules in hematopoietic cells
41. Control of extracellular matrix assembly by syndecan-2 proteoglycan
42. Heparan sulfate proteoglycans from mouse mammary epithelial cells. Cell surface proteoglycan as a receptor for interstitial collagens
43. Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1
44. Identification of an α3β1 integrin recognition site in thormbospondin-1
45. Multiple heparan sulfate chains are required for optimal syndecan-1 function
46. An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin
47. Cell attachment to thrombospondin: The role of ARG-GLY-ASP, calcium, and integrin receptors
48. Syndecan-1 mediates cell spreading in transfected human lymphoblastiod (Raji) cells
49. Identification of SVTCG in thrombospondin as the conformation-dependent, high affinity binding site for its receptor, CD36
50. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice
51. Heparan sulfate proteoglycans as adhesive and anti-invasive molecules. Syndecans and glypican have distinct functions
52. Control of morphology, cytoskeleton and migration by syndecan-4
53. Identification of an adhesion site within the syndecan-4 extracellular protein domain
54. Characterization of the high affinity cell-binding domain in the cell surface proteoglycan syndecan-4
55. Cell surface heparan sulfate proteoglycans from human vascular endothelial cells. Core protein characterization and antithrombin III binding properties
56. Analysis of transport and targeting of syndecan-1: Effect of cytoplasmic tail deletions
57. Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates the cellular internalization and degradation of thrombospondin. A process facilitated by cell-surface proteoglycans
58. Thrombospondin modulates focal adhesions in endothelial cells
59. Syndecan-4 proteoglycan regulates the distribution and activity of protein kinase C
60. Multimerisation of the cytoplasmic domain of syndecan-4 is required for its ability to activate protein kinase C
61. Malaria sporozoites and circumsporozoite proteins bind specifically to sulfated glycoconjugates
62. Cell surface proteoglycan associates with the cytoskeleton at the basolateral cell surface of mouse mammary epithelial cells
63. Molecular interactions of the syndecan core proteins
64. Platelet thrombospondin mediates attachment and spreading of human melanoma cells
65. Adhesion of B lymphoid (MPC-11) cells to type I collagen is mediated by integral membrane proteoglycan, syndecan
66. Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers
67. Molecular cloning of syndecan, an integral membrane protein
68. Integrins: Emerging paradigms of signal transduction
69. Heparan sulfate-mediated binding of epithelial cell surface proteoglycan to thrombospondin
70. Disulfides modulate RGD-inhibitable cell adhesive activity of thrombospondin
71. Activation of protein kinase C precedes α5β1 integrin-mediated cell spreading on fibronectin
72. Beta 1 integrin- and proteoglycan-mediated stimulation of T lymphoma cell adhesion and mitogen-activated protein kinase signaling by thrombospondin-1 and thrombospondin-1 peptides
73. A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formation
74. Syndecans: Synergistic activators of cell adhesion
75. Integrin modulation by lateral association
76. Activated T-cell adhesion to thormbospondin is mediated by the VLA-4 and VLA-5 integrins
77. Integrin transmembrane signaling and cytoskeletal control
78. Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells
79. The syndecans, tuners of transmembrane signaling