-
1
-
-
80855143597
-
A human endogenous retrovirus K dUTPase triggers a TH1, TH17 cytokine response: does it have a role in psoriasis?
-
Ariza M.-E., Williams M.V. A human endogenous retrovirus K dUTPase triggers a TH1, TH17 cytokine response: does it have a role in psoriasis?. J. Invest. Dermatol. 2011, 131:2419-2427.
-
(2011)
J. Invest. Dermatol.
, vol.131
, pp. 2419-2427
-
-
Ariza, M.-E.1
Williams, M.V.2
-
2
-
-
60549097111
-
The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway
-
Ariza M.-E., Glaser R., Kaumaya P.T.P., Jones C., Williams M.V. The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway. J. Immunol. 2009, 182:851-859.
-
(2009)
J. Immunol.
, vol.182
, pp. 851-859
-
-
Ariza, M.-E.1
Glaser, R.2
Kaumaya, P.T.P.3
Jones, C.4
Williams, M.V.5
-
3
-
-
5644258283
-
Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase
-
Barabás O., Pongrácz V., Kovári J., Wilmanns M., Vértessy B.G. Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. J. Biol. Chem. 2004, 279:42907-42915.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 42907-42915
-
-
Barabás, O.1
Pongrácz, V.2
Kovári, J.3
Wilmanns, M.4
Vértessy, B.G.5
-
4
-
-
77954237882
-
Network organization of the human autophagy system
-
Behrends C., Sowa M.E., Gygi S.P., Harper J.W. Network organization of the human autophagy system. Nature 2010, 466:68-76.
-
(2010)
Nature
, vol.466
, pp. 68-76
-
-
Behrends, C.1
Sowa, M.E.2
Gygi, S.P.3
Harper, J.W.4
-
5
-
-
0037337310
-
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
-
Blagoev B., Kratchmarova I., Ong S.-E., Nielsen M., Foster L.J., Mann M. A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. Nat. Biotechnol. 2003, 21:315-318.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 315-318
-
-
Blagoev, B.1
Kratchmarova, I.2
Ong, S.-E.3
Nielsen, M.4
Foster, L.J.5
Mann, M.6
-
6
-
-
3342875968
-
Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism
-
Chan S., Segelke B., Lekin T., Krupka H., Cho U.S., Kim M.-Y., So M., Kim C.-Y., Naranjo C.M., Rogers Y.C., et al. Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. J. Mol. Biol. 2004, 341:503-517.
-
(2004)
J. Mol. Biol.
, vol.341
, pp. 503-517
-
-
Chan, S.1
Segelke, B.2
Lekin, T.3
Krupka, H.4
Cho, U.S.5
Kim, M.-Y.6
So, M.7
Kim, C.-Y.8
Naranjo, C.M.9
Rogers, Y.C.10
-
7
-
-
58149213882
-
Phage-mediated intergeneric transfer of toxin genes
-
Chen J., Novick R.P. Phage-mediated intergeneric transfer of toxin genes. Science 2009, 323:139-141.
-
(2009)
Science
, vol.323
, pp. 139-141
-
-
Chen, J.1
Novick, R.P.2
-
8
-
-
0029913512
-
Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha
-
Chu R., Lin Y., Rao M.S., Reddy J.K. Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 1996, 271:27670-27676.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 27670-27676
-
-
Chu, R.1
Lin, Y.2
Rao, M.S.3
Reddy, J.K.4
-
9
-
-
2342420635
-
Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer
-
Dubrovay Z., Gáspári Z., Hunyadi-Gulyás E., Medzihradszky K.F., Perczel A., Vértessy B.G. Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer. J. Biol. Chem. 2004, 279:17945-17950.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 17945-17950
-
-
Dubrovay, Z.1
Gáspári, Z.2
Hunyadi-Gulyás, E.3
Medzihradszky, K.F.4
Perczel, A.5
Vértessy, B.G.6
-
10
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature 2002, 420:629-635.
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
11
-
-
33947219266
-
Large-scale mapping of human protein-protein interactions by mass spectrometry
-
Ewing R.M., Chu P., Elisma F., Li H., Taylor P., Climie S., McBroom-Cerajewski L., Robinson M.D., O'Connor L., Li M., et al. Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol. Syst. Biol. 2007, 3:89.
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 89
-
-
Ewing, R.M.1
Chu, P.2
Elisma, F.3
Li, H.4
Taylor, P.5
Climie, S.6
McBroom-Cerajewski, L.7
Robinson, M.D.8
O'Connor, L.9
Li, M.10
-
12
-
-
70049089339
-
The flexible motif V of Epstein-Barr virus deoxyuridine 5'-triphosphate pyrophosphatase is essential for catalysis
-
Freeman L., Buisson M., Tarbouriech N., Van der Heyden A., Labbé P., Burmeister W.P. The flexible motif V of Epstein-Barr virus deoxyuridine 5'-triphosphate pyrophosphatase is essential for catalysis. J. Biol. Chem. 2009, 284:25280-25289.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 25280-25289
-
-
Freeman, L.1
Buisson, M.2
Tarbouriech, N.3
Van der Heyden, A.4
Labbé, P.5
Burmeister, W.P.6
-
13
-
-
32844474149
-
EBV-encoded dUTPase induces immune dysregulation: Implications for the pathophysiology of EBV-associated disease
-
Glaser R., Litsky M.L., Padgett D.A., Baiocchi R.A., Yang E.V., Chen M., Yeh P.E., Green-Church K.B., Caligiuri M.A., Williams M.V. EBV-encoded dUTPase induces immune dysregulation: Implications for the pathophysiology of EBV-associated disease. Virology 2006, 346:205-218.
-
(2006)
Virology
, vol.346
, pp. 205-218
-
-
Glaser, R.1
Litsky, M.L.2
Padgett, D.A.3
Baiocchi, R.A.4
Yang, E.V.5
Chen, M.6
Yeh, P.E.7
Green-Church, K.B.8
Caligiuri, M.A.9
Williams, M.V.10
-
14
-
-
0037050004
-
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
-
Ho Y., Gruhler A., Heilbut A., Bader G.D., Moore L., Adams S.-L., Millar A., Taylor P., Bennett K., Boutilier K., et al. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 2002, 415:180-183.
-
(2002)
Nature
, vol.415
, pp. 180-183
-
-
Ho, Y.1
Gruhler, A.2
Heilbut, A.3
Bader, G.D.4
Moore, L.5
Adams, S.-L.6
Millar, A.7
Taylor, P.8
Bennett, K.9
Boutilier, K.10
-
15
-
-
0035836765
-
A comprehensive two-hybrid analysis to explore the yeast protein interactome
-
Ito T., Chiba T., Ozawa R., Yoshida M., Hattori M., Sakaki Y. A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc. Natl. Acad. Sci. USA 2001, 98:4569-4574.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4569-4574
-
-
Ito, T.1
Chiba, T.2
Ozawa, R.3
Yoshida, M.4
Hattori, M.5
Sakaki, Y.6
-
16
-
-
70350721797
-
RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells
-
Kim D.-M., Chung K.-S., Choi S.-J., Jung Y.-J., Park S.-K., Han G.-H., Ha J.-S., Song K.-B., Choi N.-S., Kim H.-M., et al. RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. Int. J. Cancer 2009, 125:2520-2527.
-
(2009)
Int. J. Cancer
, vol.125
, pp. 2520-2527
-
-
Kim, D.-M.1
Chung, K.-S.2
Choi, S.-J.3
Jung, Y.-J.4
Park, S.-K.5
Han, G.-H.6
Ha, J.-S.7
Song, K.-B.8
Choi, N.-S.9
Kim, H.-M.10
-
17
-
-
4944241573
-
Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition
-
Koehler S.E., Ladner R.D. Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition. Mol. Pharmacol. 2004, 66:620-626.
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 620-626
-
-
Koehler, S.E.1
Ladner, R.D.2
-
18
-
-
1542616353
-
Chromosomal fragmentation in dUTPase-deficient mutants of Escherichia coli and its recombinational repair
-
Kouzminova E.A., Kuzminov A. Chromosomal fragmentation in dUTPase-deficient mutants of Escherichia coli and its recombinational repair. Mol. Microbiol. 2004, 51:1279-1295.
-
(2004)
Mol. Microbiol.
, vol.51
, pp. 1279-1295
-
-
Kouzminova, E.A.1
Kuzminov, A.2
-
19
-
-
80055100406
-
The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection
-
Leang R.S., Wu T.-T., Hwang S., Liang L.T., Tong L., Truong J.T., Sun R. The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. PLoS Pathog. 2011, 7:e1002292. 10.1371/journal.ppat.1002292.
-
(2011)
PLoS Pathog.
, vol.7
-
-
Leang, R.S.1
Wu, T.-T.2
Hwang, S.3
Liang, L.T.4
Tong, L.5
Truong, J.T.6
Sun, R.7
-
20
-
-
84865094730
-
Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44
-
Madrid A.S., Ganem D. Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44. J. Virol. 2012, 86:8693-8704.
-
(2012)
J. Virol.
, vol.86
, pp. 8693-8704
-
-
Madrid, A.S.1
Ganem, D.2
-
21
-
-
34547642519
-
Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer
-
Maiques E., Ubeda C., Tormo M.A., Ferrer M.D., Lasa I., Novick R.P., Penadés J.R. Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer. J. Bacteriol. 2007, 189:5608-5616.
-
(2007)
J. Bacteriol.
, vol.189
, pp. 5608-5616
-
-
Maiques, E.1
Ubeda, C.2
Tormo, M.A.3
Ferrer, M.D.4
Lasa, I.5
Novick, R.P.6
Penadés, J.R.7
-
22
-
-
78650307766
-
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions
-
Maul R.W., Saribasak H., Martomo S.A., McClure R.L., Yang W., Vaisman A., Gramlich H.S., Schatz D.G., Woodgate R., Wilson D.M., Gearhart P.J. Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nat. Immunol. 2011, 12:70-76.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 70-76
-
-
Maul, R.W.1
Saribasak, H.2
Martomo, S.A.3
McClure, R.L.4
Yang, W.5
Vaisman, A.6
Gramlich, H.S.7
Schatz, D.G.8
Woodgate, R.9
Wilson, D.M.10
Gearhart, P.J.11
-
23
-
-
84864049112
-
Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement
-
Muha V., Horváth A., Békési A., Pukáncsik M., Hodoscsek B., Merényi G., Róna G., Batki J., Kiss I., Jankovics F., et al. Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement. PLoS Genet. 2012, 8:e1002738. 10.1371/journal.pgen.1002738.
-
(2012)
PLoS Genet.
, vol.8
-
-
Muha, V.1
Horváth, A.2
Békési, A.3
Pukáncsik, M.4
Hodoscsek, B.5
Merényi, G.6
Róna, G.7
Batki, J.8
Kiss, I.9
Jankovics, F.10
-
24
-
-
77953478153
-
The phage-related chromosomal islands of Gram-positive bacteria
-
Novick R.P., Christie G.E., Penadés J.R. The phage-related chromosomal islands of Gram-positive bacteria. Nat. Rev. Microbiol. 2010, 8:541-551.
-
(2010)
Nat. Rev. Microbiol.
, vol.8
, pp. 541-551
-
-
Novick, R.P.1
Christie, G.E.2
Penadés, J.R.3
-
25
-
-
80052274318
-
Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination
-
Pécsi I., Szabó J.E., Adams S.D., Simon I., Sellers J.R., Vértessy B.G., Tóth J. Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination. Proc. Natl. Acad. Sci. USA 2011, 108:14437-14442.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 14437-14442
-
-
Pécsi, I.1
Szabó, J.E.2
Adams, S.D.3
Simon, I.4
Sellers, J.R.5
Vértessy, B.G.6
Tóth, J.7
-
26
-
-
84861438630
-
The dUTPase enzyme is essential in Mycobacterium smegmatis
-
Pécsi I., Hirmondo R., Brown A.C., Lopata A., Parish T., Vertessy B.G., Tóth J. The dUTPase enzyme is essential in Mycobacterium smegmatis. PLoS ONE 2012, 7:e37461. 10.1371/journal.pone.0037461.
-
(2012)
PLoS ONE
, vol.7
-
-
Pécsi, I.1
Hirmondo, R.2
Brown, A.C.3
Lopata, A.4
Parish, T.5
Vertessy, B.G.6
Tóth, J.7
-
27
-
-
0037019315
-
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
-
Petersen-Mahrt S.K., Harris R.S., Neuberger M.S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 2002, 418:99-103.
-
(2002)
Nature
, vol.418
, pp. 99-103
-
-
Petersen-Mahrt, S.K.1
Harris, R.S.2
Neuberger, M.S.3
-
28
-
-
79959754068
-
Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme
-
Tchigvintsev A., Singer A.U., Flick R., Petit P., Brown G., Evdokimova E., Savchenko A., Yakunin A.F. Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme. Biochem. J. 2011, 437:243-253.
-
(2011)
Biochem. J.
, vol.437
, pp. 243-253
-
-
Tchigvintsev, A.1
Singer, A.U.2
Flick, R.3
Petit, P.4
Brown, G.5
Evdokimova, E.6
Savchenko, A.7
Yakunin, A.F.8
-
29
-
-
77953478024
-
Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands
-
Tormo-Más M.á., Mir I., Shrestha A., Tallent S.M., Campoy S., Lasa í., Barbé J., Novick R.P., Christie G.E., Penadés J.R. Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands. Nature 2010, 465:779-782.
-
(2010)
Nature
, vol.465
, pp. 779-782
-
-
Tormo-Más, M.Á.1
Mir, I.2
Shrestha, A.3
Tallent, S.M.4
Campoy, S.5
Lasa, Í.6
Barbé, J.7
Novick, R.P.8
Christie, G.E.9
Penadés, J.R.10
-
30
-
-
37749006455
-
SaPI mutations affecting replication and transfer and enabling autonomous replication in the absence of helper phage
-
úbeda C., Maiques E., Barry P., Matthews A., Tormo M.Á., Lasa í., Novick R.P., Penadés J.R. SaPI mutations affecting replication and transfer and enabling autonomous replication in the absence of helper phage. Mol. Microbiol. 2008, 67:493-503.
-
(2008)
Mol. Microbiol.
, vol.67
, pp. 493-503
-
-
úbeda, C.1
Maiques, E.2
Barry, P.3
Matthews, A.4
Tormo, M.Á.5
Lasa, Í.6
Novick, R.P.7
Penadés, J.R.8
-
31
-
-
34548702237
-
Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase
-
Varga B., Barabás O., Kovári J., Tóth J., Hunyadi-Gulyás é., Klement é., Medzihradszky K.F., Tölgyesi F., Fidy J., Vértessy B.G. Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase. FEBS Lett. 2007, 581:4783-4788.
-
(2007)
FEBS Lett.
, vol.581
, pp. 4783-4788
-
-
Varga, B.1
Barabás, O.2
Kovári, J.3
Tóth, J.4
Hunyadi-Gulyás, É.5
Klement, É.6
Medzihradszky, K.F.7
Tölgyesi, F.8
Fidy, J.9
Vértessy, B.G.10
-
32
-
-
0030755997
-
Flexible glycine rich motif of Escherichia coli deoxyuridine triphosphate nucleotidohydrolase is important for functional but not for structural integrity of the enzyme
-
Vertessy B.G. Flexible glycine rich motif of Escherichia coli deoxyuridine triphosphate nucleotidohydrolase is important for functional but not for structural integrity of the enzyme. Proteins 1997, 28:568-579.
-
(1997)
Proteins
, vol.28
, pp. 568-579
-
-
Vertessy, B.G.1
-
33
-
-
61849128423
-
Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases
-
Vértessy B.G., Tóth J. Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases. Acc. Chem. Res. 2009, 42:97-106.
-
(2009)
Acc. Chem. Res.
, vol.42
, pp. 97-106
-
-
Vértessy, B.G.1
Tóth, J.2
-
34
-
-
0032472214
-
The complete triphosphate moiety of non-hydrolyzable substrate analogues is required for a conformational shift of the flexible C-terminus in E. coli dUTP pyrophosphatase
-
Vertessy B.G., Larsson G., Persson T., Bergman A.C., Persson R., Nyman P.O. The complete triphosphate moiety of non-hydrolyzable substrate analogues is required for a conformational shift of the flexible C-terminus in E. coli dUTP pyrophosphatase. FEBS Lett. 1998, 421:83-88.
-
(1998)
FEBS Lett.
, vol.421
, pp. 83-88
-
-
Vertessy, B.G.1
Larsson, G.2
Persson, T.3
Bergman, A.C.4
Persson, R.5
Nyman, P.O.6
-
35
-
-
0035834388
-
The guanine nucleotide-binding switch in three dimensions
-
Vetter I.R., Wittinghofer A. The guanine nucleotide-binding switch in three dimensions. Science 2001, 294:1299-1304.
-
(2001)
Science
, vol.294
, pp. 1299-1304
-
-
Vetter, I.R.1
Wittinghofer, A.2
-
36
-
-
13844296398
-
DUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors
-
Whittingham J.L., Leal I., Nguyen C., Kasinathan G., Bell E., Jones A.F., Berry C., Benito A., Turkenburg J.P., Dodson E.J., et al. dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors. Structure 2005, 13:329-338.
-
(2005)
Structure
, vol.13
, pp. 329-338
-
-
Whittingham, J.L.1
Leal, I.2
Nguyen, C.3
Kasinathan, G.4
Bell, E.5
Jones, A.F.6
Berry, C.7
Benito, A.8
Turkenburg, J.P.9
Dodson, E.J.10
-
37
-
-
78650956818
-
Evidence for a second messenger function of dUTP during Bax mediated apoptosis of yeast and mammalian cells
-
Williams D., Norman G., Khoury C., Metcalfe N., Briard J., Laporte A., Sheibani S., Portt L., Mandato C.A., Greenwood M.T. Evidence for a second messenger function of dUTP during Bax mediated apoptosis of yeast and mammalian cells. Biochim. Biophys. Acta 2011, 1813:315-321.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 315-321
-
-
Williams, D.1
Norman, G.2
Khoury, C.3
Metcalfe, N.4
Briard, J.5
Laporte, A.6
Sheibani, S.7
Portt, L.8
Mandato, C.A.9
Greenwood, M.T.10
-
38
-
-
79959350868
-
HIV DNA is heavily uracilated, which protects it from autointegration
-
Yan N., O'Day E., Wheeler L.A., Engelman A., Lieberman J. HIV DNA is heavily uracilated, which protects it from autointegration. Proc. Natl. Acad. Sci. USA 2011, 108:9244-9249.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 9244-9249
-
-
Yan, N.1
O'Day, E.2
Wheeler, L.A.3
Engelman, A.4
Lieberman, J.5
-
39
-
-
53349117774
-
High-quality binary protein interaction map of the yeast interactome network
-
Yu H., Braun P., Yildirim M.A., Lemmens I., Venkatesan K., Sahalie J., Hirozane-Kishikawa T., Gebreab F., Li N., Simonis N., et al. High-quality binary protein interaction map of the yeast interactome network. Science 2008, 322:104-110.
-
(2008)
Science
, vol.322
, pp. 104-110
-
-
Yu, H.1
Braun, P.2
Yildirim, M.A.3
Lemmens, I.4
Venkatesan, K.5
Sahalie, J.6
Hirozane-Kishikawa, T.7
Gebreab, F.8
Li, N.9
Simonis, N.10
|