A human endogenous retrovirus K dUTPase triggers a TH 1, T H 17 cytokine response: Does it have a role in psoriasis

Journal of Investigative Dermatology

Volumn 131, Issue 12, 2011, Pages 2419-2427

  Ariza, Maria Eugenia ^a,b   Williams, Marshall V ^b,c  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; PROTEOME; RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENDOGENOUS RETROVIRUS; ENZYME ACTIVITY; GENE MUTATION; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; INNATE IMMUNITY; KERATINOCYTE; LANGERHANS CELL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PURIFICATION; PSORIASIS; TH1 CELL; TH17 CELL;

EID: 80855143597     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.217     Document Type: Article

References (75)

1. Ariza ME, Glaser R, Kaumaya PTP et al. (2009) The Epstein-Barr virus (EBV)-encoded dUTPase activates NF-kB through the TLR2 and MyD88-dependent signaling pathway. J Immunol 182:851-9
2. Ariza ME, Rivallier P, Glaser R et al. (2011) EBV-encoded dUTPase gene expression profiling studies reveal novel functions in innate immunity, immune evasion and oncogenesis. (in press)
3. Ayehunie S, Lamore S, Bellevance K et al. (2003) Harvest proliferation and functional testing of human dendritic cells. MatTek Corporation Tech Bulletin 322:26-30
4. Baker BS, Ovigne JM, Powles AV et al. (2003) Normal keratinocytes express Toll-like receptors (TLRs) 1, 2, and 5: modulation of TLR expression in chronic plaque psoriasis. Br J Dermatol 148: 670-679 (Pubitemid 36629744)
5. Balaj L, Lessard R, Dai L et al. (2011) Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat Commun 2:180
6. Bannert N, Kurth R (2004) Retroelements and the human genome: new perspectives on an old relation. Proc Natl Acad Sci USA 101(Suppl 2):14572-9 (Pubitemid 39346726)
7. Barbulescu M, Turner G, Seaman MI et al. (1999) Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans. Current Biol 9:861-8 (Pubitemid 29456003)
8. Barton A, Thomson W, Ke X et al. (2008) Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nat Genet 40:1156-9
9. Belshaw R, Dawson ALA, Woolven-Allen J et al. (2005) Genomewide screening reveals high levels of insertional polymorphism in the human endogenous retrovirus family HERV-K (HML2): implications for present-day activity. J Virol 79:12507-14 (Pubitemid 41346113)
10. Bessis D, Moles JP, Basset-Seguin N et al. (2004) Differential expression of a human endogenous retrovirus E transmembrane envelope glycoprotein in normal, psoriatic and atopic dermatitis human skin. Br J Dermatol 151:735-45
11. Blank M, Shoenfeld Y, Perl A (2009) Cross-talk of the environment with the host genome and the immune system through endogenous retroviruses in systemic lupus erythematosus. Lupus 18:1136-43
12. Bowcock AM (2005) The genetics of psoriasis and autoimmunity. Annu Rev Genomics Hum Genet 6:93-122 (Pubitemid 41397077)
13. Bowcock AM, Krueger JG (2005) Getting under the skin: the immunogenetics of psoriasis. Nat Rev Immunol 5:699-711 (Pubitemid 43090738)
14. Büscher K, Trefzer U, Hofmann M et al. (2005) Expression of human endogenous retrovirus K in melanomas and melanoma cell lines. Cancer Res 65:4172-80 (Pubitemid 40775655)
15. Chang M, Li Y, Yan C et al. (2008) Variants in the 5q31 cytokine gene cluster are associated with psoriasis. Genes Immun 9:176-81 (Pubitemid 351351659)
16. Colmegna I, Garry RF (2006) Role of endogenous retroviruses in autoimmune diseases. Inf Dis Clin N Am 20:913-29 (Pubitemid 44752025)
17. Contreras-Galindo R, Kaplan M, Leissner P et al. (2008) Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer. J Virol 82:9329-36
18. Dauter Z, Persson R, Rosengern AM et al. (1999) Crystal structure of dUTPase from equine infectious anaemia virus: active site metal binding in a substrate analogue complex. J Mol Biol 285:655-73 (Pubitemid 29041799)
19. De Jager PL, Jia X, Wang J et al. (2009) Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 41:776-82
20. Dewannieux M, Harper F, Richaud A et al. (2006) Identification of an infectious progenitor for the multiple-copy HERV-K human endogenous retroelements. Genome Res 16:1548-56 (Pubitemid 44878493)
21. Elder JT (2006) PSORS1: linking genetics and immunology. J Invest Dermatol 126:1205-6 (Pubitemid 43997894)
22. Elder JT, Bruce AT, Gudjonsson JE et al. (2010) Molecular dissection of psoriasis: integrating genetics and biology. J Invest Dermatol 130:1213-26
23. Fang Y, Wu N, Yan W et al. (2007) Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes. PloS Biol 5:e158
24. Fiser A, Vertessy BG (2000) Altered subunit communication in subfamilies of trimeric dUTPases. Biochem Biophys Res Comm 279:534-42 (Pubitemid 32016750)
25. Flanagan J, Middeldorp J, Sculley T (2003) Localization of the Epstein-Barr virus LMP 1 to exosomes. J Gen Virol 84:1871-9 (Pubitemid 36805923)
26. Foerster J, Nolte I, Junge J et al. (2005) Haplotype sharing analysis identifies a retroviral dUTPase as candidate susceptibility gene for psoriasis. J Invest Dermatol 124:99-102 (Pubitemid 40100954)
27. Franke A, McGovern DPB, Barrett JC et al. (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 42:1118-26
28. Freeman L, Buisson M, Tarbouriech N et al. (2009) The flexible motif V of Epstein-Barr virus deoxyuridine 50-triphosphate pyrophosphatase is essential for catalysis. J Biol Chem 284:25280-9
29. Gateva V, Sandling JK, Hom G et al. (2009) A large-scale replication study identifies TNIP1, PRDM1, JAZF1. UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet 41:1228-33
30. Glaser R, Litsky ML, Padgett DA et al. (2006) EBV-encoded dUTPase induces immune dysregulation: implications for the pathophysiology of EBV-associated malignant disease. Virology 346:205-18 (Pubitemid 43254711)
31. Gould SJ, Booth AM, Hildreth JE (2003) The Trojan exosome hypothesis. Proc Natl Acad Sci USA 100:10592-7 (Pubitemid 37140073)
32. Guilhou JJ, Moles JP (2008) New hypotheses in the genetics of psoriasis and other complex diseases. Dermatol 216:87-92
33. Harris JM, Haynes RH, McIntosh EM (1997) A consensus sequence for a functional human endogenous retrovirus K (HERV-K) dUTPase. Biochem Cell Biol 75:143-51 (Pubitemid 127733138)
34. Harris JM, McIntosh EM, Muscat EO (1999) Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target. J Mol Biol 288:275-87 (Pubitemid 29209877)
35. Harris JM, McIntosh EM, Muscat GE (2000) Expression and cytoplasmic localization of deoxyuridine triphosphate pyrophosphatase encoded by a human endogenous retrovirus. Arch Virol 145:353-63 (Pubitemid 30121253)
36. Hedrick MN, Lonsdorf AS, Shirakawa AK et al. (2009) CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. J Clin Invest 119:2317-29
37. Hohenadletal C, Germaier H, Walchner M et al. (1999) Transcriptional activation of endogenous retroviral sequences in human epidermal keratinocytes by UVB irradiation. J Invest Dermatol 113:587-94 (Pubitemid 29489621)
38. Hollox EJ, Huffmeier U, Zeeuwen PL et al. (2008) Psoriasis is associated with increased beta-defensin genomic copy number. Nat Genet 40:23-5
39. Huffmeier U, Uebe S, Ekici AB et al. (2010) Common variants at TRAF3IP2 are associated with increased susceptibility to psoriatic arthritis and psoriasis. Nat Genet 42:996-9
40. Iversen OJ (1990) The expression of retrovirus-like particles in psoriasis. J Invest Dermatol 95:41S-3S
41. Izquierdo-Useros N, Puertas MC, Borras FE et al. (2011) Exosomes and retroviruses: the chicken or the egg. Cell Microbiol 13:10-7
42. Johanneson B, Lima G, von Salome J et al. (2002) A major susceptibility locus for systemic lupus erythemathosus maps to chromosome 1q31. Am J Hum Genet 71:1060-72
43. Kakalacheva K, Munz C, Lunemann JD (2011) Viral triggers of multiple sclerosis. Biochim Biophys Acta 1812:132-40
44. Kim TH, Jeon YJ, Yi JM et al. (2004) The distribution and expression of HERV families in the human genome. Mol Cells 18:87-93
45. Larsson G, Svensson LA, Nyman PO (1996) Crystal structure of the Escherichia coli dUTPase in complex with a substrate analogue (dUDP). Nat Struct Biol 3:532-8 (Pubitemid 26174702)
46. Lowes MA, Bowcock AM, Krueger JG (2007) Pathogenesis and therapy of psoriasis. Nature 445:866873
47. Mayer J, Sauter M, Racz A et al. (1999) An almost-intact human endogenous retrovirus K on human chromosome 7. Nat Genet 21:257-8 (Pubitemid 29124927)
48. Mayer J, Meese EU (2003) Presence of dUTPase in the various human endogenous retroviruses K (HERV-K) families. J Mol Evol 57:642-9 (Pubitemid 37543978)
49. McGeoch DJ (1990) Protein sequence comparisons show that the 'pseudo-proteases' encoded by poxviruses and certain retroviruses belong to the deoxyuridine triphosphatase family. Nucleic Acids Res 18:4105-10
50. Mol CD, Harris JM, McIntosh EM et al. (1996) Human dUTP pyropho-sphatase: uracil recognition by a b hairpin and active sites formed by three separate subunits. Structure 4:1077-92 (Pubitemid 26369773)
51. Moles JP, Tesniere A, Guilhou JJ (2005) A new endogenous retroviral sequence is expressed in skin of patients with psoriasis. Br J Dermatol 153:83-9 (Pubitemid 41044532)
52. Moyes D, Griffiths DJ, Venables PJ (2007) Insertional polymorphisms: a new lease of life for endogenous retroviruses in human disease. Trends Genet 23:326-33 (Pubitemid 46978355)
53. Moyes DL, Martin A, Sawcer S et al. (2005) The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease. Genomics 86:337-41 (Pubitemid 41096703)
54. Nair RP, Duffin KC, Helms C et al. (2009) Genome-wide scan reveals association of psoriasis with IL-23 and NF-kB pathways. Nat Genet 41:199-204
55. Nair RP, Stuart P, Henseler T et al. (2000) Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C. Am J Hum Genet 66:1833-44 (Pubitemid 30480090)
56. Nair RP, Stuart PE, Nistor I et al. (2006) Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility-1 gene. Am J Hum Genetics 78:827-51
57. Nestle FO, Di Meglio P, Qin JZ et al. (2009) Skin immune sentinels in health and disease. Nat Rev Immunol 9:679-91
58. Nickoloff BJ (2007) Cracking the cytokine code in psoriasis. Nat Med 13:242-4 (Pubitemid 46376653)
59. Nickoloff BJ, Xin H, Nestle FO et al. (2007) The cytokine and chemokine network in psoriasis. Clin Dermatol 25:568-73 (Pubitemid 350103656)
60. Nord J, Nyman PO, Larsson G et al. (2001) The C-terminus of dUTPase: observation on flexibility using NMR. FEBS Lett 432:228-32 (Pubitemid 32217833)
61. Pelchen-Matthews A, Raposo G, Marsh M (2004) Endosomes, exosomes and Trojan viruses. Trends Microbiol 12:310-6 (Pubitemid 38829651)
62. Rebora A (2005) Human endogenous retroviruses and their possible impact on dermatology. J Am Acad Dermatol 52:e11-9
63. Roberson EDO, Bowcock AM (2010) Psoriasis genetics: breaking the barrier. Trends Genet 26:415-23
64. Sun LD, Cheng H, Wang ZX et al. (2010) Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat Genet 42:1005-9
65. Stuart PE, Nair RP, Ellinghaus E et al. (2010) Genome-wide association analysis identifies three psoriasis susceptibility loci. Nat Genet 42:1000-4
66. Studebaker AW, Ariza ME, Williams MV (2005) Depletion of uracil-DNA glycosylase activity using a novel protein transduction approach results in decreased cell proliferation. Biochem Biophys Res Comm 334:509-15 (Pubitemid 40982396)
67. Takacs E, Barabas O, Petoukhov MV et al. (2009) Molecular shape and predominant role of b-strand swapping in organization of dUTPase oligomers. FEBS Lett 583:865-71
68. Tarbouriech N, Buisson M, Seigneurin JM et al. (2005) The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases. Structure 13:1299-310 (Pubitemid 41262097)
69. Turner G, Barbulescu M, Su M et al. (2001) Insertional polymorphisms of full-length endogenous retroviruses in humans. Current Biol 11:1531-5 (Pubitemid 32931016)
70. Vallhov H, Gutzeit C, Johansson SM et al. (2011) Exosomes containing glycoprotein 350 released by EBV-transformed B cells selectively target B cells through CD21 and block EBV infection in vitro. J Immunol 186:73-82
71. Voisset C, Weiss RA, Griffiths DJ (2008) Human RNA "rumor" viruses: the search for novel human retroviruses in chronic disease. Microbiol Mol Biol Rev 72:157-96 (Pubitemid 351398059)
72. Waldman WJ, Williams MV, Lemeshow SA et al. (2008) Subclinical epstein barr virus infection: a potential atherosclerosis risk factor. Brain Behav Immun 22:215-33
73. Williams MV (1985) Effects of mercury (II) compounds on the activities of dUTPases from various sources. Mol Pharmacol 29:288-92
74. Zaba LC, Fuentes-Duculan J, Eungdamrong NJ et al. (2009) Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells. J Invest Dermatol 129:79-88
75. Zhang XJ, Huang W, Yang S et al. (2009) Psoriasis genome-wide association study identifies susceptibility variants within LEC gene cluster at 1q21. Nat Genet 41:205-10