Crystal structure of the Mycobacterium tuberculosis dUTPase: Insights into the catalytic mechanism

Journal of Molecular Biology

Volumn 341, Issue 2, 2004, Pages 503-517

  Chan, Sum ^a   Segelke, Brent ^b   Lekin, Timothy ^b   Krupka, Heike ^b   Cho, Uhn Soo ^c   Kim, Min Young ^c   So, Minyoung ^c   Kim, Chang Yub ^c   Naranjo, Cleo M ^c   Rogers, Yvonne C ^c   Park, Min S ^c   Waldo, Geoffrey S ^c   Pashkov, Inna ^a   Cascio, Duilio ^a   Perry, Jeanne L ^a   Sawaya, Michael R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

drug design; dUTPase; EIAV, equine infectious anemia virus; FIV, feline immunodeficiency virus; IPTG, isopropyl thio D galactoside; mechanism; nucleotidohydrolase; SDS PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis; tuberculosis

Indexed keywords

ALPHA,BETA IMIDODEOXYURIDINE TRIPHOSPHATE; BACTERIAL ENZYME; BASE; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DNA DIRECTED DNA POLYMERASE BETA; ENZYME INHIBITOR; MAGNESIUM ION; METAL ION; PARATHION; PHOSPHORUS; SOLVENT; UNCLASSIFIED DRUG; WATER;

ACCURACY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL LEVEL; CRYSTAL STRUCTURE; CYTOTOXICITY; DEPLETION; ENZYME ASSAY; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; GEOMETRY; HYDROLYSIS; MOLECULE; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL;

EQUIDAE; EQUINE INFECTIOUS ANEMIA VIRUS; FELIDAE; FELINE IMMUNODEFICIENCY VIRUS; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 3342875968     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.06.028     Document Type: Article

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