P,p'-Methoxyl-diphenyl diselenide protects against amyloid-β induced cytotoxicity in vitro and improves memory deficits in vivo

Behavioural Brain Research

Volumn 247, Issue , 2013, Pages 241-247

  Pinton, Simone ^a   Souza, Ana Cristina ^a   Sari, Marcel H M ^a   Ramalho, Rita M ^b   Rodriguesb, Cecília M P ^b   Nogueiraa, Cristina W ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Amyloid peptide; Apoptosis; C Jun N terminal kinase; Memory impairment; P,p' Methoxyl diphenyl diselenide

Indexed keywords

AMYLOID BETA PROTEIN; CASPASE 3; CASPASE 9; DONEPEZIL; NEUROPROTECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; P,P' METHOXYL DIPHENYL DISELENIDE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CELL; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FETUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; BENZENE DERIVATIVES; CASPASE 3; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CYTOTOXINS; MAZE LEARNING; MEMORY DISORDERS; MICE; NEURONS; NEUROPROTECTIVE AGENTS; ORGANOSELENIUM COMPOUNDS; PEPTIDE FRAGMENTS; RATS;

EID: 84876842421     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2013.03.034     Document Type: Article

References (43)

1. Selkoe DJ. Alzheimer's disease. Cold Spring Harbor Perspectives in Biology2011;3:1-14.
2. Reitz C. Alzheimer's disease and the amyloid cascade hypothesis: a criticalreview. International Journal of Alzheimer's Disease 2012;2012:369808.
3. Cummings JL. Alzheimer's disease. The New England Journal Of Medicine2004;351:12.
4. Shimohama S. Apoptosis in Alzheimer's disease-an update. Apoptosis2000;5:9-16.
5. Zhu X, Raina AK, Rottkamp CA, Aliev G, Perry G, Boux H, et al. Activationand redistribution of c-jun N-terminal kinase/stress activated protein kinasein degenerating neurons in Alzheimer's disease. Journal of Neurochemistry2001;76:435-41.
6. Yoshida H, Hastie CJ, McLauchlan H, Cohen P, Goedert M. Phosphorylationof microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase(JNK). Journal of Neurochemistry 2004;90:352-8.
7. Dhanasekaran DN, Reddy EP. JNK signaling in apoptosis. Oncogene2008;27:6245-51.
8. Colombo A, Bastone A, Ploia C, Sclip A, Salmona M, Forloni G, et al. JNK regulatesAPP cleavage and degradation in a model of Alzheimer's disease. Neurobiologyof Disease 2009;33:518-25.
9. Morishima Y, Gotoh Y, Zieg J, Barrett T, Takano H, Flavell R, et al. Beta-amyloidinduces neuronal apoptosis via a mechanism that involves the c-Jun N-terminalkinase pathway and the induction of Fas ligand. Journal of Neuroscience2001;21:7551-60.
10. Viana RJ, Ramalho RM, Nunes AF, Steer CJ, Rodrigues CM. Modula-tion of amyloid-beta peptide-induced toxicity through inhibition of JNKnuclear localization and caspase-2 activation. Journal of Alzheimer's Disease2010;22:557-68.
11. Ramin M, Azizi P, Motamedi F, Haghparast A, Khodagholi F. Inhibition of JNKphosphorylation reverses memory deficit induced by beta-amyloid (1-42)associated with decrease of apoptotic factors. Behavioural Brain Research2011;217:424-31.
12. Sclip A, Antoniou X, Colombo A, Camici GG, Pozzi L, Cardinetti D, et al. c-Jun N-terminal kinase regulates soluble Abeta oligomers and cognitive impairmentin AD mouse model. Journal of Biological Chemistry 2011;286:43871-80.
13. Braithwaite SP, Schmid RS, He DN, Sung ML, Cho S, Resnick L, et al. Inhibitionof c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.Neurobiology of Disease 2010;39:311-7.
14. Moussaoui S, Obinu MC, Daniel N, Reibaud M, Blanchard V, Imperato A. Theantioxidant ebselen prevents neurotoxicity and clinical symptoms in a primatemodel of Parkinson's disease. Experimental Neurology 2000;166:235-45.
15. Namura S, Nagata I, Takami S, Masayasu H, Kikuchi H. Ebselen reducescytochrome c release from mitochondria and subsequent DNA fragmentationafter transient focal cerebral ischemia in mice. Stroke 2001;32:1906-11.
16. Lovell MA, Xiong S, Lyubartseva G, Markesbery WR. Organoselenium (Sel-Plexdiet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1mice. Free Radical Biology and Medicine 2009;46:1527-33.
17. Nogueira CW, Rocha JBT. Diphenyl Diselenide a Janus-Faced Molecule. Journalof the Brazilian Chemical Society 2010;21(11):2055-71.
18. Rosa RM, Flores DG, Appelt HR, Braga AL, Henriques JA, Roesler R. Facilita-tion of long-term object recognition memory by pretraining administration ofdiphenyl diselenide in mice. Neuroscience Letters 2003;341:217-20.
19. Stangherlin EC, Luchese C, Pinton S, Rocha JB, Nogueira CW. Sub-chronicalexposure to diphenyl diselenide enhances acquisition and retention of spatialmemory in rats. Brain Research 2008;1201:106-13.
20. Souza AC, Bruning CA, Leite MR, Zeni G, Nogueira CW. Diphenyl diselenideimproves scopolamine-induced memory impairment in mice. BehaviouralPharmacology 2010;21:556-62.
21. da Rocha JT, Pinton S, Mazzanti A, Mazzanti CM, Beckemann DV, Nogueira CW,et al. Diphenyl diselenide ameliorates cognitive deficits induced by a model ofmenopause in rats. Behavioural Pharmacology 2012;23:98-104.
22. Dias GR, Vieira FA, Dobrachinski F, Bridi JC, Balk Rde S, Soares FA, et al.Diphenyl diselenide diet intake improves spatial learning and memory deficitsin hypothyroid female rats. International Journal of Developmental Neuro-science 2012;30:83-9.
23. Pinton S, Bruning CA, Sartori Oliveira CE, Prigol M, Nogueira CW. Therapeu-tic effect of organoselenium dietary supplementation in a sporadic dementiaof Alzheimer's type model in rats. The Journal of Nutritional Biochemistry2013;24:311-7.
24. Pinton S, da Rocha JT, Gai BM, Prigol M, da Rosa LV, Nogueira CW. Neuro-protector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadicdementia of Alzheimer's type in mice: contribution of antioxidant mechanism.Cell Biochemistry and Function 2011;29:235-43.
25. Pinton S, da Rocha JT, Zeni G, Nogueira CW. Organoselenium improves mem-ory decline in mice: involvement of acetylcholinesterase activity. NeuroscienceLetters 2010;472:56-60.
26. Pinton S, Sampaio TB, Ramalho RM, Rodrigues CM, Nogueira CW. p,p'-Methoxyl-diphenyl diselenide prevents neurodegeneration and glial cellactivation induced by streptozotocin in rats. Journal of Alzheimer's Disease2013;33:133-44.
27. Brewer GJ, Torricelli JR, Evege EK, Price PJ. Optimized survival of hippocampalneurons in B27-supplemented neurobasal, a new serum-free medium combi-nation. Journal of Neuroscience Research 1993;35:567-76.
28. Paulmier C. In selenium reagents and intermediates in organic synthesis. In:Paulmier C, editor. Selenoorganic functional groups. Oxford: Pergamon Press;1986. p. 25.
29. Ianiski FR, Alves CB, Souza AC, Pinton S, Roman SS, Rhoden CR, et al.Protective effect of meloxicam-loaded nanocapsules against amyloid-betapeptide-induced damage in mice. Behavioural Brain Research 2012;230:100-7.
30. Wang HH, Chou CJ, Liao JF, Chen CF. Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice. European Journal of Pharmacology2001;413:221-5.
31. Haley TJ, McCormick WG. Pharmacological effects produced by intracerebralinjection of drugs in the conscious mouse. British Journal of Pharmacology andChemotherapy 1957;12:12-5.
32. Morris R. Developments of a water-maze procedure for studying spatial learn-ing in the rat. Journal of Neuroscience Methods 1984;11:47-60.
33. Ramalho RM, Viana RJ, Low WC, Steer CJ, Rodrigues CM. Bile acids and apoptosismodulation: an emerging role in experimental Alzheimer's disease. Trends inMolecular Medicine 2008;14:54-62.
34. Tillement L, Lecanu L, Papadopoulos V. Alzheimer's disease: effects of beta-amyloid on mitochondria. Mitochondrion 2011;11:13-21.
35. Yelamos J, Schreiber V, Dantzer F. Toward specific functions of poly(ADP-ribose)polymerase-2. Trends in Molecular Medicine 2008;14:169-78.
36. Colurso GJ, Nilson JE, Vervoort LG. Quantitative assessment of DNA fragmenta-tion and beta-amyloid deposition in insular cortex and midfrontal gyrus frompatients with Alzheimer's disease. Life Sciences 2003;73:1795-803.
37. Bjorkblom B, Vainio JC, Hongisto V, Herdegen T, Courtney MJ, Coffey ET. AllJNKs can kill, but nuclear localization is critical for neuronal death. Journal ofBiological Chemistry 2008;283:19704-13.
38. Sharma N, Deshmukh R, Bedi KL. SP600125, a competitive inhibitor of JNKattenuates streptozotocin induced neurocognitive deficit and oxidative stressin rats. Pharmacology Biochemistry and Behavior 2010;96:386-94.
39. Nassif M, Hoppe J, Santin K, Frozza R, Zamin LL, Simao F, et al. Beta-amyloidpeptide toxicity in organotypic hippocampal slice culture involves Akt/PKB,GSK-3beta, and PTEN. Neurochemistry International 2007;50:229-35.
40. Ramalho RM, Nunes AF, Dias RB, Amaral JD, Lo AC, D'Hooge R, et al. Taurour-sodeoxycholic acid suppresses amyloid beta-induced synaptic toxicity in vitroand in APP/PS1 mice. Neurobiology of Aging 2013;34:551-61.
41. Tayeb HO, Yang HD, Price BH, Tarazi FI. Pharmacotherapies for Alzheimer'sdisease: beyond cholinesterase inhibitors. Pharmacology & Therapeutics2012;134:8-25.
42. Bevilaqua LR, Kerr DS, Medina JH, Izquierdo I, Cammarota M. Inhibition ofhippocampal Jun N-terminal kinase enhances short-term memory but blockslong-term memory formation and retrieval of an inhibitory avoidance task.European Journal of Neuroscience 2003;17:897-902.
43. Sherrin T, Blank T, Hippel C, Rayner M, Davis RJ, Todorovic C. Hippocampalc-Jun-N-terminal kinases serve as negative regulators of associative learning.Journal of Neuroscience 2010;30:13348-61.