Importance of serrated polyps in colorectal carcinogenesis

ANZ Journal of Surgery

Volumn 83, Issue 5, 2013, Pages 325-330

  Liang, Jennifer J ^a   Bissett, Ian ^a   Kalady, Matthew ^a   Bennet, Ana ^a   Church, James M ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Molecular pathway; Serrated polyps

Indexed keywords

TUMOR MARKER;

COLORECTAL TUMOR; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTESTINE MUCOSA; INTESTINE POLYP; METABOLISM; PATHOLOGY; PRECANCER; REVIEW;

COLORECTAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTESTINAL MUCOSA; INTESTINAL POLYPS; PRECANCEROUS CONDITIONS; TUMOR MARKERS, BIOLOGICAL;

EID: 84876822143     PISSN: 14451433     EISSN: 14452197     Source Type: Journal    
DOI: 10.1111/j.1445-2197.2012.06269.x     Document Type: Review

References (90)

1. Vogelstein B, Fearon ER, Hamilton SR etal. Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 1988; 319: 525-532.
2. Goldman H, Ming S, Hickock DF. Nature and significance of hyperplastic polyps of the human colon. Arch. Pathol. 1970; 89: 349-354.
3. Urbanski SJ, Kossakowska AE, Marcon N, Bruce WR. Mixed hyperplastic adenomatous polyps - an underdiagnosed entity. Report of a case of adenocarcinoma arising within a mixed hyperplastic adenomatous polyp. Am. J. Surg. Pathol. 1984; 8: 551-556.
4. Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am. J. Surg. Pathol. 1990; 14: 524-537.
5. Torlakovic E, Skovlund E, Snover DC, Torlakovic G, Nesland JM. Morphologic reappraisal of serrated colorectal polyps. Am. J. Surg. Pathol. 2003; 27: 65-81.
6. Tateyama H, Li W, Takahashi E, Miura Y, Sugiura H, Eimoto T. Apoptosis index and apoptosis-related antigen expression in serrated adenoma of the colorectum: the saw-toothed structure may be related to inhibition of apoptosis. Am. J. Surg. Pathol. 2002; 26: 249-256.
7. Cheng L, Lai MD. Aberrant crypt foci as microscopic precursors of colorectal cancer. World J. Gastroenterol. 2003; 9: 2642-2649.
8. Jass JR. Pathogenesis of colorectal cancer. Surg. Clin. North Am. 2002; 82: 891-904.
9. Jass JR, Walsh MD, Barker M, Simms LA, Young J, Leggett BA. Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability. Eur. J. Cancer 2002; 38: 858-866.
10. Jass JR, Whitehall VL, Young J, Leggett BA. Emerging concepts in colorectal neoplasia. Gastroenterology 2002; 123: 862-876.
11. Jass JR, Young J, Leggett BA. Evolution of colorectal cancer: change of pace and change of direction. J. Gastroenterol. Hepatol. 2002; 17: 17-26.
12. Beach R, Chan AO, Wu TT etal. BRAF mutations in aberrant crypt foci and hyperplastic polyposis. Am. J. Pathol. 2005; 166: 1069-1075.
13. Chan AO, Broaddus RR, Houlihan PS, Issa JP, Hamilton SR, Rashid A. GpG island methylation in aberrant crypt foci of the colorectum. Am. J. Pathol. 2002; 160: 1823-1830.
14. Fenoglio-Preiser CM, Noffsinger A. Aberrant crypt foci: a review. Toxicol. Pathol. 1999; 27: 632-642.
15. Bird RP. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett. 1987; 37: 147-151.
16. Hurlstone DP, Cross SS. Role of aberrant crypt foci detected using high-magnification-chromoscopic colonoscopy in human colorectal carcinogenesis. J. Gastroenterol. Hepatol. 2005; 20: 173-181.
17. Hurlstone DP, Fujii T. Practical uses of chromoendoscopy and magnification at colonoscopy. Gastrointest. Endosc. Clin. N. Am. 2005; 15: 687-702.
18. Hurlstone DP, Karajeh M, Sanders DS, Drew SK, Cross SS. Rectal aberrant crypt foci identified using high-magnification-chromoscopic colonoscopy: biomarkers for flat and depressed neoplasia. Am. J. Gastroenterol. 2005; 100: 1283-1289.
19. Hurlstone DP, Sanders DS, Lobo AJ, McAlindon ME, Cross SS. Indigo carmine-assisted high-magnification chromoscopic colonoscopy for the detection and characterisation of intraepithelial neoplasia in ulcerative colitis: a prospective evaluation. Endoscopy 2005; 37: 1186-1192.
20. Bariol C, Hawkins NJ, Turner JJ, Meagher AP, Williams DB, Ward RL. Histopathological and clinical evaluation of serrated adenomas of the colon and rectum. Mod. Pathol. 2003; 16: 417-423.
21. Jaramillo E, Watanabe M, Slezak P, Rubio C. Flat neoplastic lesions of the colon and rectum detected by high-resolution video endoscopy and chromoscopy. Gastrointest. Endosc. 1995; 42: 114-122.
22. Jaramillo E, Watanabe M, Befrits R, Ponce de Leon E, Rubio C, Slezak P. Small, flat colorectal neoplasias in long-standing ulcerative colitis detected by high-resolution electronic video endoscopy. Gastrointest. Endosc. 1996; 44: 15-22.
23. Matsumoto T, Mizuno M, Shimizu M, Manabe T, Iida M. Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma. J. Clin. Pathol. 1999; 52: 513-516.
24. Matsumoto T, Mizuno M, Shimizu M, Manabe T, Iida M, Fujishima M. Serrated adenoma of the colorectum: colonoscopic and histologic features. Gastrointest. Endosc. 1999; 49: 736-742.
25. Yao T, Kouzuki T, Kajiwara M, Matsui N, Oya M, Tsuneyoshi M. 'Serrated' adenoma of the colorectum, with reference to its gastric differentiation and its malignant potential. J. Pathol. 1999; 187: 511-517.
26. Spring KJ, Zhao ZZ, Karamatic R etal. High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology 2006; 131: 1400-1407.
27. Lazarus R, Junttila OE, Karttunen TJ, Makinen MJ. The risk of metachronous neoplasia in patients with serrated adenoma. Am. J. Clin. Pathol. 2005; 123: 349-359.
28. Ladas SD, Kitsanta P, Triantafyllou K, Tzathas C, Spiliadi C, Raptis SA. Cell turnover of serrated adenomas. J. Pathol. 2005; 206: 62-67.
29. Horkko TT, Makinen MJ. Colorectal proliferation and apoptosis in serrated versus conventional adenoma-carcinoma pathway: growth, progression and survival. Scand. J. Gastroenterol. 2003; 38: 1241-1248.
30. Iwabuchi M, Sasano H, Hiwatashi N etal. Serrated adenoma: a clinicopathological, DNA ploidy, and immunohistochemical study. Anticancer Res. 2000; 20: 1141-1147.
31. Chandra A, Sheikh AA, Cerar A, Talbot IC. Clinico-pathological aspects of colorectal serrated adenomas. World J. Gastroenterol. 2006; 12: 2770-2772.
32. Yano T, Sano Y, Iwasaki J etal. Distribution and prevalence of colorectal hyperplastic polyps using magnifying pan-mucosal chromoendoscopy and its relationship with synchronous colorectal cancer: prospective study. J. Gastroenterol. Hepatol. 2005; 20: 1572-1577.
33. Makinen JM, Makinen MJ, Karttunen TJ. Serrated adenocarcinoma of the rectum associated with perianal Paget's disease: a case report. Histopathology 2002; 41: 177-179.
34. Yamauchi T, Watanabe M, Hasegawa H etal. Serrated adenoma developing into advanced colon cancer in 2 years. J. Gastroenterol. 2002; 37: 467-470.
35. Makinen MJ. Colorectal serrated adenocarcinoma. Histopathology 2007; 50: 131-150.
36. Chan TL, Zhao W, Leung SY, Yuen ST. BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas. Cancer Res. 2003; 63: 4878-4881.
37. Sawyer EJ, Cerar A, Hanby AM etal. Molecular characteristics of serrated adenomas of the colorectum. Gut 2002; 51: 200-206.
38. Uchida H, Ando H, Maruyama K etal. Genetic alterations of mixed hyperplastic adenomatous polyps in the colon and rectum. Jpn J. Cancer Res. 1998; 89: 299-306.
39. Yamamoto T, Konishi K, Yamochi T etal. No major tumorigenic role for beta-catenin in serrated as opposed to conventional colorectal adenomas. Br. J. Cancer 2003; 89: 152-157.
40. Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ. BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am. J. Surg. Pathol. 2004; 28: 1452-1459.
41. Ajioka Y, Watanabe H, Jass JR, Yokota Y, Kobayashi M, Nishikura K. Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum. Gut 1998; 42: 680-684.
42. Kambara T, Simms LA, Whitehall VL etal. BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 2004; 53: 1137-1144.
43. Park SJ, Rashid A, Lee JH, Kim SG, Hamilton SR, Wu TT. Frequent CpG island methylation in serrated adenomas of the colorectum. Am. J. Pathol. 2003; 162: 815-822.
44. Konishi K, Yamochi T, Makino R etal. Molecular differences between sporadic serrated and conventional colorectal adenomas. Clin. Cancer Res. 2004; 10: 3082-3090.
45. Whitehall VL, Walsh MD, Young J, Leggett BA, Jass JR. Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability. Cancer Res. 2001; 61: 827-830.
46. Hawkins NJ, Ward RL. Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J. Natl Cancer Inst. 2001; 93: 1307-1313.
47. Kolch W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J. 2000; 351 (Pt 2): 289-305.
48. Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002; 418: 934.
49. Nucci MR, Robinson CR, Longo P, Campbell P, Hamilton SR. Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa. Hum. Pathol. 1997; 28: 1396-1407.
50. Takayama T, Ohi M, Hayashi T etal. Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology 2001; 121: 599-611.
51. O'Brien MJ, Yang S, Clebanoff JL etal. Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype. Am. J. Surg. Pathol. 2004; 28: 423-434.
52. Jass JR. Colorectal cancer: a multipathway disease. Crit. Rev. Oncog. 2006; 12: 273-287.
53. Jass JR, Baker K, Zlobec I etal. Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer. Histopathology 2006; 49: 121-131.
54. Higashidani Y, Tamura S, Morita T etal. Analysis of K-ras codon 12 mutation in flat and nodular variants of serrated adenoma in the colon. Dis. Colon Rectum 2003; 46: 327-332.
55. Otori K, Oda Y, Sugiyama K etal. High frequency of K-ras mutations in human colorectal hyperplastic polyps. Gut 1997; 40: 660-663.
56. McGivern A, Wynter CV, Whitehall VL etal. Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer. Fam. Cancer 2004; 3: 101-107.
57. Domingo E, Espin E, Armengol M etal. Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation. Genes Chromosomes Cancer 2004; 39: 138-142.
58. Domingo E, Niessen RC, Oliveira C etal. BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes. Oncogene 2005; 24: 3995-3998.
59. Jubb AM, Bell SM, Quirke P. Methylation and colorectal cancer. J. Pathol. 2001; 195: 111-134.
60. Robertson KD, Wolffe AP. DNA methylation in health and disease. Nat. Rev. Genet. 2000; 1: 11-19.
61. Robertson KD, Jones PA. DNA methylation: past, present and future directions. Carcinogenesis 2000; 21: 461-467.
62. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 2003; 349: 2042-2054.
63. Grady WM. Epigenetic events in the colorectum and in colon cancer. Biochem. Soc. Trans. 2005; 33: 684-688.
64. Toyota M, Ohe-Toyota M, Ahuja N, Issa JP. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc. Natl Acad. Sci. U.S.A. 2000; 97: 710-715.
65. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. GpG island methylator phenotype in colorectal cancer. Proc. Natl Acad. Sci. U.S.A. 1999; 96: 8681-8686.
66. Toyota M, Ho C, Ahuja N etal. Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Res. 1999; 59: 2307-2312.
67. Hawkins N, Norrie M, Cheong K etal. CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology 2002; 122: 1376-1387.
68. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv. Cancer Res. 1998; 72: 141-196.
69. Young J, Simms LA, Biden KG etal. Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. Am. J. Pathol. 2001; 159: 2107-2116.
70. Dong SM, Lee EJ, Jeon ES, Park CK, Kim KM. Progressive methylation during the serrated neoplasia pathway of the colorectum. Mod. Pathol. 2005; 18: 170-178.
71. Laiho P, Kokko A, Vanharanta S etal. Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis. Oncogene 2007; 26: 312-320.
72. Noda H, Kato Y, Yoshikawa H etal. Microsatellite instability caused by hMLH1 promoter methylation increases with tumor progression in right-sided sporadic colorectal cancer. Oncology 2005; 69: 354-362.
73. Kuismanen SA, Holmberg MT, Salovaara R, de la Chapelle A, Peltomaki P. Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers. Am. J. Pathol. 2000; 156: 1773-1779.
74. Deng G, Bell I, Crawley S etal. BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. Clin. Cancer Res. 2004; 10: 191-195.
75. Jass JR. Hyperplastic polyps and colorectal cancer: is there a link? Clin. Gastroenterol. Hepatol. 2004; 2: 1-8.
76. Jass JR. HNPCC and sporadic MSI-H colorectal cancer: a review of the morphological similarities and differences. Fam. Cancer 2004; 3: 93-100.
77. Jass JR. Serrated adenoma of the colorectum and the DNA-methylator phenotype. Nat. Clin. Pract. Oncol. 2005; 2: 398-405.
78. Rex DK, Rahmani EY. New endoscopic finding associated with hyperplastic polyps. Gastrointest. Endosc. 1999; 50: 704-706.
79. Oka S, Tanaka S, Hiyama T etal. Clinicopathologic and endoscopic features of colorectal serrated adenoma: differences between polypoid and superficial types. Gastrointest. Endosc. 2004; 59: 213-219.
80. Jaramillo E, Tamura S, Mitomi H. Endoscopic appearance of serrated adenomas in the colon. Endoscopy 2005; 37: 254-260.
81. Morita T, Tamura S, Miyazaki J, Higashidani Y, Onishi S. Evaluation of endoscopic and histopathological features of serrated adenoma of the colon. Endoscopy 2001; 33: 761-765.
82. Higuchi T, Sugihara K, Jass JR. Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 2005; 47: 32-40.
83. Huang CS, O'Brien MJ, Yang S, Farraye FA. Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway. Am. J. Gastroenterol. 2004; 99: 2242-2255.
84. Li SC, Burgart L. Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps. Arch. Pathol. Lab. Med. 2007; 131: 440-445.
85. Peyssonnaux C, Eychene A. The Raf/MEK/ERK pathway: new concepts of activation. Biol. Cell 2001; 93: 53-62.
86. Torlakovic E, Snover DC. Serrated adenomatous polyposis in humans. Gastroenterology 1996; 110: 748-755.
87. Mitomi H, Sada M, Kobayashi K etal. Different apoptotic activity and p21(WAF1/CIP1), but not p27(Kip1), expression in serrated adenomas as compared with traditional adenomas and hyperplastic polyps of the colorectum. J. Cancer Res. Clin. Oncol. 2003; 129: 449-455.
88. Vakiani E, Yantiss RK. Pathologic features and biologic importance of colorectal serrated polyps. Adv. Anat. Pathol. 2009; 16: 79-91.
89. Snover DC, Jass JR, Fenoglio-Preiser C, Batts KP. Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept. Am. J. Clin. Pathol. 2005; 124: 380-391.
90. Rex DK, Ahnen DJ, Baron JA etal. Serrated lesions of the colorectum: review and recommendations from an expert panel. Am. J. Gastroenterol. 2012; 107: 1315-1329.