Molecular Differences between Sporadic Serrated and Conventional Colorectal Adenomas

Clinical Cancer Research

Volumn 10, Issue 9, 2004, Pages 3082-3090

  Konishi, Kazuo ^a   Yamochi, Toshiko ^a   Makino, Reiko ^a   Kaneko, Kazuhiro ^a   Yamamoto, Taikan ^a   Nozawa, Hisako ^a   Katagiri, Atsushi ^a   Ito, Hiroaki ^a   Nakayama, Kentarou ^b   Ota, Hidekazu ^a   Mitamura, Keiji ^a   Imawari, Michio ^a  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHIMANE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; RAF PROTEIN; RAS PROTEIN;

ADENOMA; ADENOMATOUS POLYP; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE MUTATION; HISTOLOGY; HUMAN; HUMAN TISSUE; MALE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL;

ADENOMA; ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; CARRIER PROTEINS; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RAF; TUMOR SUPPRESSOR PROTEIN P53;

EID: 2442568714     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-03-0334     Document Type: Article

References (62)

1. Morson BC. Precancerous and early malignant lesions of the large intestine. Br J Surg 1968;55:725-31.
2. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-70.
3. Powell SM, Zilz N, Beazer-Barclay Y, et al. APC mutations occur early during colorectal tumorigenesis. Nature (Lond) 1992;359:235-7.
4. Forrester K, Almoguera C, Hank K, Grizzle WE, Perucho M. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature (Lond) 1987;327:298-303.
5. Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of ras gene mutations in human colorectal cancers Nature (Lond) 1987;327:293-7.
6. Thiagalingam S, Lengauer C, Leach FS, et al. Evaluation of candidate tumor suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 1996;13:343-6.
7. Kikuchi-Yanoshita R, Konishi M, Fukunari H, Tanaka K, Miyaki M. Loss of expression of the DCC gene during progression of colorectal carcinomas in familial adenomatous polyposis and non-familial adenomatous polyposis patients. Cancer Res 1992;52:3801-3.
8. Baker SJ, Fearon ER, Nigro JM, et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (Wash DC) 1989; 244:217-21.
9. Ohue M, Tomita N, Monden T, et al. A frequent alteration of p53 gene in carcinoma in adenoma of colon. Cancer Res 1994;54:4798-804.
10. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994;54:4855-78.
11. Fishel R, Lescoe MK, Rao MR, et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 1993;75:1027-38.
12. Nicolaides NC, Papadopoulos N, Liu B, et al. Mutation of two PMS homologues in hereditary nonpolyposis colon cancer. Nature (Lond) 1994;371:75-80.
13. Papadopoulos N, Nicolaides NC, Liu B, et al. Mutations of GTBP in genetically unstable cells Science (Wash DC) 1995;268:1915-7.
14. Bronner CE, Baker SM, Morrison PT, et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (Lond) 1994;368:258-61.
15. Leach FS, Nicolaides NC, Papadopoulos N, et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 1993; 75:1215-25.
16. Papadopoulos N, Nicolaides NC, Wei YF, et al. Mutation of a mutL homolog in hereditary colon cancer. Science (Wash DC) 1994;263: 1625-9.
17. Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 1998;95:6870-5.
18. Cunningham JM, Christensen ER, Tester DJ, et al. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res 1998;58:3455-60.
19. Goldman H, Ming S, Hickock DF. Nature and significance of hyperplastic polyps of the human colon. Arch Pthol 1970;89:349-54.
20. Estrada RG, Spjut HJ. Hyperplastic polyps of the large bowel. Am J Surg Pathol 1980;4:127-33.
21. Otori K, Oda Y, Sugiyama K, et al. High frequency of K-ras mutations in human colorectal hyperplastic polyps. Gut 1997;40:660-3.
22. Chan TL, Zhao W, Leung SY, Yuen S. BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas. Cancer Res 2003;63:4878-81.
23. Konishi M, Kikuchi-Yanoshita R, Tanaka K, et al. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology 1996;111:307-17.
24. Lothe RA, Andersen SN, Hofstad B, et al. Deletion of 1p loci and microsatellite instability in colorectal polyps Genes Chromosomes Cancer 1995;14:182-8.
25. Rashid A, Houlihan PS, Booker S, Petersen GM, Giardiello FM, Hamilton SR. Phenotypic and molecular characteristics of hyperplastic polyposis. Gastroenterology 2000;119:323-32.
26. Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol 1990;14:524-37.
27. Makinen MJ, George SM, Jernvall P, Makela J, Vihko P, Karttunen TJ. Colorectal carcinoma associated with serrated adenoma: prevalence, histological features, and prognosis. J Pathol 2001;193:286-94.
28. Yao T, Kouzuki T, Kajiwara M, Matsui N, Oya M, Tsuneyoshi M. 'Serrated' adenoma of the colorectum, with reference to its gastric differentiation and its malignant potential. J Pathol 1999;187:511-7.
29. Iino H, Jass JR, Simms LA, et al. DNA. microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? J Clin Pathol (Lond) 1999;52: 5-9.
30. Fogt F, Brien T, Brown CA, Hartmann CJ, Zimmerman RL, Odze RD. Genetic alterations in serrated adenomas: comparison to conventional adenomas and hyperplastic polyps. Hum Pathol 2002;33:87-91.
31. Yamamoto T, Konishi K, Yamochi T, et al. No major tumorigenic role for β-catenin in serrated as opposed to conventional colorectal adenomas. Br J Cancer 2003;89:152-7.
32. Jass JR, Burt R. Hyperplastic polyposis. In: Hamilton SR, Aaltonnen LA, editors. WHO international classification of tumors: pathology and genetics of tumors of the digestive system, 3 ed. Berlin: Springer-Verlag;2000. p. 135-6.
33. Konishi K, Fujü T, Boku N, et al. Clinicopathological differences between colonic and rectal carcinomas: are they based on the same mechanism of carcinogenesis? Gut 1999;45:818-21.
34. Japanese Research Society for Cancer of the Colon and Rectum. General rules for clinical and pathological studies on cancer of the colon, rectum, and anus. 1st English ed. Tokyo: Kanehara, 1997.
35. Hawkins NJ, Ward RL. Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst (Bethesda) 2001;93:1307-13.
36. Ito T, Kaneko K, Makino R, et al. Prognostic value of p53 mutations in patients with locally advanced esophageal carcinoma treated with definitive chemoradiotherapy. J Gastroenterol 2001;36:303-11.
37. Kurahashi T, Kaneko K, Makino R, Mitamura K. Colorectal carcinoma with special reference to growth pattern classifications: clinicopathological characteristics and genetic changes. J Gastroenterol 2002; 37:354-62.
38. Makino R, Kaneko K, Kurahashi T, Matsumura T, Mitamura K. Detection of mutation of the p53 gene with high sensitivity by fluorescence-based PCR-SSCP analysis using low-pH buffer and an automated DNA sequencer in a large number of DNA samples. Mutat Res 2000; 452:83-90.
39. Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature (Lond.) 2002;417:949-54.
40. Boland CR, Thibodeau SN, Hamilton SR, et al. National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998;58:5248-57.
41. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984; 133:1710-5.
42. Brown DC, Gatter KC. Monoclonal antibody Ki-67: its use in histopathology. Histopathology 1990;17:489-503.
43. Hiyama T, Yokozaki H, Shimamoto F, et al. Frequent p53 gene mutations in serrated adenomas of the colorectum. J Pathol 1998;186: 131-9.
44. Rubio CA, Rodensjo M. p53 overexpression in flat serrated adenomas and flat tubular adenomas of the colorectal mucosa. J Cancer Res Clin Oncol 1995;121:571-6.
45. Kang M, Mitomi H, Sada M, et al. Ki-67, p53, and Bcl-2 expression of serrated adenomas of the colon. Am J Surg Pathol 1997;21:417-23.
46. Dehari R. Infrequent APC mutations in serrated adenoma. Tohoku J Exp Med 2001;193:181-6.
47. Uchida H, Ando H, Maruyama K, et al. Genetic alterations of mixed hyperplastic adenomatous polyps in the colon and rectum. Jpn J Cancer Res 1998;89:299-306.
48. Ajioka Y, Watanabe H, Jass JR, Yokota Y, Kobayashi M, Nishikura K. Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum. Gut 1998;42:680-4.
49. Sawyer EJ, Cerar A, Hanby AM, et al. Molecular characteristics of serrated adenomas of the colorectum. Gut 2002;51:200-6.
50. Jass JR, Iino H, Ruszkiewicz A, et al. Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut 2000;47:43-9.
51. Park SJ, Rashid A, Lee JH, Kim SG, Hamilton SR, Wu T. Frequent CpG island methylation in serrated adenomas of the colorectum. Am J Pathol 2003;162:815-22.
52. Jass JR, Do KA, Simms LA, et al. Morphology of sporadic colorectal cancer with DNA replication errors. Gut 1998;42:673-9.
53. Matsumoto T, Mizuno M, Shimizu M, Manabe T, Iida M. Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma. J Clin Pathol (Lond) 1999;52:513-6.
54. Rijcken FEW, Hollema H, Kleibeuker JH. Proximal adenomas in hereditary non-polyposis colorectal cancer are prone to rapid malignant transformation. Gut 2002;50:382-6.
55. Jass JR, Young J, Leggett BA. Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum. Histopathology 2000; 37:295-301.
56. Goldstein NS, Bhanot P, Odish E, Hunter S. Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas. Am J Clin Pathol 2003;119:778-96.
57. Peyssonnaux C, Eychene A. The Raf/MEK/EPK pathway: new concepts of activation. Biol Cell 2001;93:53-62.
58. Yuen ST, Davies H, Chan TL, et al. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res 2002;62:6451-5.
59. Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. RAF/RAS oncogenes and mismatch-repair status. Nature (Lond) 2002;418:934.
60. Wang L, Cunningham JM, Winters JL, et al. BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair. Cancer Res 2003;63:5209-52.
61. Torlakovic E, Skovlund E, Snover DC, Torlakovic G, Nesland JM. Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol 2003;27:65-81.
62. Jass JR, Biden KG, Cummings MC, et al. Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways J Clin Pathol (Lond) 1999;52:455-60.