Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard

Lipids in Health and Disease

Volumn 12, Issue 1, 2013, Pages

  Xu, Jiqu ^a,b   Gao, Hui ^c   Song, Lin ^d   Yang, Wei ^c   Chen, Chang ^e   Deng, Qianchun ^a,b   Huang, Qingde ^a,b   Yang, Jin'E ^a,b   Huang, Fenghong ^a,b  

^a INSTITUTE OF PLANT PROTECTION   (China)

^b Hubei Key Laboratory of Lipid Chemistry and Nutrition   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d Hubei Xinhua Hospital   (China)

^e CHINA THREE GORGES UNIVERSITY   (China)

Author keywords

lipoic acid; Flaxseed oil; High fat diet; Lipid accumulation; Oxidant stress

Indexed keywords

CATALASE; CHOLESTEROL; FAT; LARD; SOYBEAN OIL; SUPEROXIDE DISMUTASE; THIOCTIC ACID; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROL GROUP; CONTROLLED STUDY; FAT INTAKE; FATTY LIVER; FEEDING; LINSEED; LIPID DIET; LIPID PEROXIDATION; LIPID STORAGE; LIVER; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; RODENT;

ANIMALS; DIET, HIGH-FAT; DIETARY FATS; FATTY LIVER; HUMANS; LINSEED OIL; LIPID ACCUMULATION PRODUCT; LIPID METABOLISM; MALE; OXIDATIVE STRESS; RATS; THIOCTIC ACID;

GLYCINE MAX; RATTUS; RODENTIA;

EID: 84876810763     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-12-58     Document Type: Article

References (45)

1. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH, Hepatology 2004 40 6 1387 1395 10.1002/hep.20466 15565570 (Pubitemid 39657013)
2. Nonalcoholic fatty liver in asia: firmly entrenched and rapidly gaining ground. Chitturi S, Wong VW, Farrell G, J Gastroenterol Hepatol 2011 26 Suppl 1 163 172 21199528
3. Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model. de Meijer VE, Le HD, Meisel JA, Akhavan Sharif MR, Pan A, Nose V, Puder M, Metabolism 2010 59 8 1092 1105 10.1016/j.metabol.2009.11.006 20060143
4. Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis. Anderson N, Borlak J, Pharmacol Rev 2008 60 3 311 357 10.1124/pr.108.00001 18922966
5. Steatohepatitis: a tale of two hits? Day CP, James OF, Gastroenterology 1998 114 4 842 845 10.1016/S0016-5085(98)70599-2 9547102 (Pubitemid 28160420)
6. Effect of the use of ground flaxseed on quality and chemical composition of bread. Mentes O, Bakkalbasi E, Ercan R, Food Sci Technol Int 2008 14 4 299 306 10.1177/1082013208097192
7. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Barcelo-Coblijn G, Murphy EJ, Prog Lipid Res 2009 48 6 355 374 10.1016/j.plipres.2009.07.002 19619583
8. Flaxseed oil attenuates nonalcoholic fatty liver of hyperlipidemic hamsters. Yang SF, Tseng JK, Chang YY, Chen YC, J Agric Food Chem 2009 57 11 5078 5083 10.1021/jf900499v 19453104
9. The effect of linseed oil supplementation on performance, fatty acid composition and oxidative status of rabbits. Trebušak T, Levart A, Voljč M, Tomažin U, Pirman T, Acta agriculturae Slovenica 2011 98 2 119 125
10. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM, Biochim Biophys Acta 2009 1790 10 1149 1160 10.1016/j.bbagen.2009.07.026 19664690
11. alpha-Lipoic acid: a metabolic antioxidant which regulates NF-kappa B signal transduction and protects against oxidative injury. Packer L, Drug Metab Rev 1998 30 2 245 275 10.3109/03602539808996311 9606603 (Pubitemid 28266862)
12. Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Evans JL, Goldfine ID, Diabetes technology & therapeutics 2000 2 3 401 413 10.1089/15209150050194279 23776732
13. Alpha-lipoic acid as a biological antioxidant. Packer L, Witt EH, Tritschler HJ, Free Radic Biol Med 1995 19 2 227 250 10.1016/0891-5849(95)00017- R 7649494
14. Lipoic acid administration prevents nonalcoholic steatosis linked to long-term high-fat feeding by modulating mitochondrial function. Valdecantos MP, Perez-Matute P, Gonzalez-Muniesa P, Prieto-Hontoria PL, Moreno-Aliaga MJ, Martinez JA, J Nutr Biochem 2012 23 12 1676 1684 10.1016/j.jnutbio.2011.11.011 22464149
15. alpha-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats. Jung TS, Kim SK, Shin HJ, Jeon BT, Hahm JR, Roh GS, Liver Int 2012 32 10 1565 1573 10.1111/j.1478-3231.2012.02857.x 22863080
16. Flaxseed oil and alpha-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet. Xu JQ, Yang W, Deng QC, Huang QD, Yang JE, Huang FH, Lipids Health Dis 2012 11 148 10.1186/1476-511X-11-148 23113997
17. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Kono Y, Arch Biochem Biophys 1978 186 1 189 195 10.1016/0003-9861(78)90479-4 24422 (Pubitemid 8290500)
18. A simple method for determination of serum catalase activity and revision of reference range. Goth L, Clin Chim Acta 1991 196 2-3 143 151 2029780
19. Effect of adriamycin on the activities of superoxide dismutase, glutathione peroxidase and catalase in tissues of mice. Sazuka Y, Tanizawa H, Takino Y, Jpn J Cancer Res 1989 80 1 89 94 10.1111/j.1349-7006.1989.tb02250.x 2496064 (Pubitemid 20027204)
20. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Moron MS, Depierre JW, Mannervik B, Biochim Biophys Acta 1979 582 1 67 78 10.1016/0304-4165(79)90289-7 760819 (Pubitemid 9065588)
21. Microsomal lipid peroxidation. Buege JA, Aust SD, Methods Enzymol 1978 52 302 310 672633
22. Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet. Xu JQ, Zhou XQ, Deng QC, Huang QD, Yang JE, Huang FH, Lipids Health Dis 2011 10 96 10.1186/1476-511X-10-96 21663699
23. Protein measurement with the Folin phenol reagent. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ, J Biol Chem 1951 193 1 265 275 14907713
24. A simple method for the isolation and purification of total lipides from animal tissues. Folch J, Lees M, Sloane Stanley GH, J Biol Chem 1957 226 1 497 509 13428781
25. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Kraegen EW, Clark PW, Jenkins AB, Daley EA, Chisholm DJ, Storlien LH, Diabetes 1991 40 11 1397 1403 10.2337/diabetes.40.11.1397 1936601
26. Model of nonalcoholic steatohepatitis. Lieber CS, Leo MA, Mak KM, Xu Y, Cao Q, Ren C, Ponomarenko A, DeCarli LM, Am J Clin Nutr 2004 79 3 502 509 14985228 (Pubitemid 41115597)
27. Effects of a long-term high-fat diet and switching from a high-fat to low-fat, standard diet on hepatic fat accumulation in Sprague-Dawley rats. Omagari K, Kato S, Tsuneyama K, Inohara C, Kuroda Y, Tsukuda H, Fukazawa E, Shiraishi K, Mune M, Dig Dis Sci 2008 53 12 3206 3212 10.1007/s10620-008-0303-1 18465233
28. Pathology of nonalcoholic steatohepatitis. Brunt EM, Hepatol Res 2005 33 2 68 71 10.1016/j.hepres.2005.09.006 16214395 (Pubitemid 41799777)
29. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Forman BM, Chen J, Evans RM, Proc Natl Acad Sci U S A 1997 94 9 4312 4317 10.1073/pnas.94.9.4312 9113986 (Pubitemid 27194238)
30. Comparative effects of perilla and fish oils on the activity and gene expression of fatty acid oxidation enzymes in rat liver. Ide T, Kobayashi H, Ashakumary L, Rouyer IA, Takahashi Y, Aoyama T, Hashimoto T, Mizugaki M, Biochim Biophys Acta 2000 1485 1 23 35 10.1016/S1388-1981(00)00026-3 10802246 (Pubitemid 30259192)
31. Effect of dietary alpha-linolenic acid on the activity and gene expression of hepatic fatty acid oxidation enzymes. Ide T, Biofactors 2000 13 1-4 9 14 11237206 (Pubitemid 32107338)
32. Supplementation with alpha-linolenic acid-rich diacylglycerol suppresses fatty liver formation accompanied by an up-regulation of beta-oxidation in Zucker fatty rats. Murase T, Aoki M, Tokimitsu I, Biochim Biophys Acta 2005 1733 2-3 224 231 15863369 (Pubitemid 40603665)
33. Stimulation of the activities of hepatic fatty acid oxidation enzymes by dietary fat rich in alpha-linolenic acid in rats. Ide T, Murata M, Sugano M, J Lipid Res 1996 37 3 448 463 8728310 (Pubitemid 26139710)
34. Flax oil-mediated activation of PPAR-gamma correlates with reduction of hepatic lipid accumulation in obese spontaneously hypertensive/NDmcr-cp rats, a model of the metabolic syndrome. Chechi K, Yasui N, Ikeda K, Yamori Y, Cheemaa SK, Br J Nutr 2010 104 9 1313 1321 10.1017/S0007114510002187 20546645
35. Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease. Videla LA, Rodrigo R, Araya J, Poniachik J, Free Radic Biol Med 2004 37 9 1499 1507 10.1016/j.freeradbiomed.2004.06.033 15454290 (Pubitemid 39349251)
36. Dietary alpha-linolenic acid lowers postprandial lipid levels with increase of eicosapentaenoic and docosahexaenoic acid contents in rat hepatic membrane. Kim HK, Choi H, Lipids 2001 36 12 1331 1336 10.1007/s11745-001-0849-7 11834085 (Pubitemid 34101227)
37. Effects of dietary alpha linolenic acid on cholesterol metabolism in male and female hamsters of the LPN strain. Morise A, Serougne C, Gripois D, Blouquit MF, Lutton C, Hermier D, J Nutr Biochem 2004 15 1 51 61 10.1016/j.jnutbio.2003.10.002 14711461 (Pubitemid 38050260)
38. Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: a microarray analysis. Yang RL, Li W, Shi YH, Le GW, Nutrition 2008 24 6 582 588 10.1016/j.nut.2008.02.002 18367378
39. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Nature 2010 464 7285 121 125 10.1038/nature08778 20203611
40. Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. Valdecantos MP, Perez-Matute P, Gonzalez-Muniesa P, Prieto-Hontoria PL, Moreno-Aliaga MJ, Martinez JA, Obesity (Silver Spring) 2012 20 10 1974 1983 10.1038/oby.2012.32
41. Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Huong DT, Ide T, Br J Nutr 2008 100 1 79 87 18062843
42. Clerodendron glandulosum. Coleb extract ameliorates high fat diet/fatty acid induced lipotoxicity in experimental models of non-alcoholic steatohepatitis. Jadeja RN, Thounaojam MC, Dandekar DS, Devkar RV, Ramachandran AV, Food Chem Toxicol 2010 48 12 3424 3431 10.1016/j.fct.2010.09.015 20849909
43. Comparative therapeutic effects of metformin and vitamin E in a model of non-alcoholic steatohepatitis in the young rat. Raso GM, Esposito E, Iacono A, Pacilio M, Cuzzocrea S, Canani RB, Calignano A, Meli R, Eur J Pharmacol 2009 604 1-3 125 131 19135440
44. Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. Petersen Shay K, Moreau RF, Smith EJ, Hagen TM, IUBMB life 2008 60 6 362 367 10.1002/iub.40 18409172
45. Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Ogborne RM, Rushworth SA, O'Connell MA, Arterioscler Thromb Vasc Biol 2005 25 10 2100 2105 10.1161/01.ATV.0000183745. 37161.6e 16123320 (Pubitemid 41416307)