Differential binding of pyruvate dehydrogenase complex-E2 epitopes by DRB1*08:01 and DRB1*11:01 is predicted by their structural motifs and correlates with disease risk

Journal of Immunology

Volumn 190, Issue 9, 2013, Pages 4516-4524

  Chow, I Ting ^a   James, Eddie A ^a   Gates, Theresa J ^a   Tan, Venus ^a   Moustakas, Antonis K ^b   Papadopoulos, George K ^c   Kwok, William W ^a,d  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b IONIAN UNIVERSITY   (Greece)

^c Faculty of Agricultural Technology   (Greece)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; EPITOPE; HLA DR ANTIGEN; HLA DRB1 ANTIGEN; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVATE DEHYDROGENASE COMPLEX E2; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ANTIGEN STRUCTURE; ANTIGENICITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CD4+ T LYMPHOCYTE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; HAPLOTYPE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; NORMAL HUMAN; PEPTIDE LIBRARY; PREDICTION; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN MOTIF; RISK ASSESSMENT;

ALLELES; ANTIGENS, VIRAL; AUTOIMMUNITY; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; HLA-DRB1 CHAINS; HUMANS; LIVER CIRRHOSIS, BILIARY; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SELF TOLERANCE; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 84876807273     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202445     Document Type: Article

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