Mutational analysis of critical residues determining antigen presentation and activation of HLA-DQ0602 restricted T-cell clones

Human Immunology

Volumn 63, Issue 3, 2002, Pages 185-193

  Reichstetter, Sandra ^a   Papadopoulos, George K ^b   Moustakas, Antonis K ^b   Swanson, Eric ^a   Liu, Andrew W ^a   Beheray, Sucheta ^a   Ettinger, Ruth A ^a,c   Nepom, Gerald T ^a,c   Kwok, William W ^a  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b Faculty of Agricultural Technology   (Greece)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Antigen presentation; IDDM; MHC; Molecular modeling; T cell receptors

Indexed keywords

HLA DQ ANTIGEN; T LYMPHOCYTE RECEPTOR;

AMINO ACID SUBSTITUTION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HYDROGEN BOND; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR MODEL; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE ACTIVATION; TOPOGRAPHY;

ANTIGEN PRESENTATION; CELL DIFFERENTIATION; CELLS, CULTURED; CLONE CELLS; DNA MUTATIONAL ANALYSIS; EPITOPES, T-LYMPHOCYTE; HLA-DQ ANTIGENS; HUMANS; LYMPHOCYTE ACTIVATION; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL; SENSITIVITY AND SPECIFICITY; SEQUENCE HOMOLOGY; T-LYMPHOCYTES;

EID: 0036128080     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(01)00377-9     Document Type: Article

References (37)

1. Genetics of type 1 diabetes
2. Molecular basis for HLA-DQ associations with IDDM
3. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus
4. HLA-DQ6-mediated protection in IDDM
5. IMGT/HLA Database - A sequence database for the human major histocompatibility complex
6. Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions
7. Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus
8. Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus
9. HLA-DQ Tetramers indentify epitope-specific T cells in peripheral blood of Herpes simplex virus type 2-infected individuals: Direct detection of immunodominant antigen-responsive cells
10. An experimentally validated panel of subfamily-specific oligonucleotide primers (V alpha 1-w29/V beta 1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction
11. Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase
12. Modelling of the MHC II allele I-A(g7) of NOD mouse: pH-dependent changes in specificity at pockets 9 and 6 explain several of the unique properties of this molecule
13. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
14. Crystal structure of I-Ak in complex with a dominant epitope of lysozyme
15. Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen
16. The class II MHC protein HLA-DR1 in complex with an endogenous peptide: Implications for the structural basis of the specificity of peptide binding
17. The crystal structure of a T cell receptor in complex with peptide and MHC class II
18. Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes
19. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
20. Structural basis of peptide binding and presentation by the type I diabetes-MHC class II molecule of NOD mice
21. A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes
22. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes
23. HLA class II region sequences, 1998
24. A peptide binding motif for HLA-DQA1*0102/DQB1*0602, the class II MHC molecule associated with dominant protection in insulin-dependent diabetes mellitus
25. HLA-DQB1 codon 57 is critical for peptide binding and recognition
26. Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules
27. Polymorphism at beta 85 and not beta 86 of HLA-DR1 is predominantly responsible for restricting the nature of the anchor side chain: Implication for concerted effects of class II MHC polymorphism
28. Engineering protein for X-ray crystallography: The murine major histocompatibility complex class II molecule I-Ad
29. Stability of empty and peptide-loaded class II major histocompatibility complex molecules at neutral and endosomal pH: Comparison to class I proteins
30. The generation of SDS-stable HLA DR dimers is independent of efficient peptide binding
31. An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex
32. Shapes of MHC restriction
33. Peptide recognition by two HLA-A2/Tax 11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures
34. Perspectives: Protein structure. Class-conscious TCR?
35. Structural basis of T cell recognition
36. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
37. X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II