Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats

Journal of Lipid Research

Volumn 54, Issue 5, 2013, Pages 1430-1438

  Shen, Ling ^a   Xiong, Ye ^a   Wang, David Q H ^b   Howles, Philip ^a   Basford, Joshua E ^a   Wang, Jiang ^a   Xiong, Yu Qing ^a   Hui, David Y ^a   Woods, Stephen C ^c   Liu, Min ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NANCHANG UNIVERSITY   (China)

Author keywords

Fatty liver; Ginseng; Obesity; Signaling pathway

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CARNITINE PALMITOYLTRANSFERASE I; GINSENOSIDE RB 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRIACYLGLYCEROL;

ACC GENE; ACYL COA OXIDASE 1 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARNITINE PALMITOYLTRANSFERASE IA GENE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; FATTY ACID OXIDATION; FATTY ACID SYNTHASE GENE; FATTY LIVER; GENE; GENE EXPRESSION REGULATION; GENE SEQUENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; LIPID STORAGE; LIPOGENESIS; LIVER WEIGHT; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA GENE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA GENE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; STEAROL COA DESATURASE 1 GENE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C GENE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DIET, HIGH-FAT; FAT BODY; FATTY LIVER; GINSENOSIDES; LIPID METABOLISM; LIPOGENESIS; LIVER; MALE; OBESITY; RATS;

EID: 84876805513     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M035907     Document Type: Article

References (32)

1. Postic, C., and J. Girard. 2008. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice. J. Clin. Invest. 118 : 829-838.
2. Neuschwander-Tetri, B. A., and S. H. Caldwell. 2003. Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference. Hepatology. 37 : 1202-1219.
3. Parekh, S., and F. A. Anania. 2007. Abnormal lipid and glucose metabolism in obesity: Implications for nonalcoholic fatty liver disease. Gastroenterology. 132 : 2191-2207.
4. Adams, L. A., and P. Angulo. 2006. Treatment of non-alcoholic fatty liver disease. Postgrad. Med. J. 82 : 315-322.
5. Kahn, B. B., T. Alquier, D. Carling, and D. G. Hardie. 2005. AMPactivated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1 : 15-25.
6. Lin, C. L., H. C. Huang, and J. K. Lin. 2007. Theafl avins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. J. Lipid Res. 48 : 2334-2343.
7. Zhou, G., R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, et al. 2001. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108 : 1167-1174.
8. Viollet, B., M. Foretz, B. Guigas, S. Horman, R. Dentin, L. Bertrand, L. Hue, and F. Andreelli. 2006. Activation of AMP-activated protein kinase in the liver: A new strategy for the management of metabolic hepatic disorders. J. Physiol. 574 : 41-53.
9. Park, S., I. S. Ahn, D. Y. Kwon, B. S. Ko, and W. K. Jun. 2008. Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways. Biosci. Biotechnol. Biochem. 72 : 2815-2823.
10. Xiong, Y., L. Shen, K. J. Liu, P. Tso, Y. Xiong, G. Wang, S. C. Woods, and M. Liu. 2010. Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes. 59 : 2505-2512.
11. Woods, S. C., R. J. Seeley, P. A. Rushing, D. D'Alessio, and P. Tso. 2003. A controlled high-fat diet induces an obese syndrome in rats. J. Nutr. 133 : 1081-1087.
12. Folch, J., M. Lees, and G. H. Sloane Stanley. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226 : 497-509.
13. Brunt, E. M., C. G. Janney, A. M. Di Bisceglie, B. A. Neuschwander-Tetri, and B. R. Bacon. 1999. Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions. Am. J. Gastroenterol. 94 : 2467-2474.
14. Sanyal, A. J. 2002. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology. 123 : 1705-1725.
15. Rector, R. S., L. P. Thyfault, R. T. Morris, M. J. Laye, S. J. Borengasser, F. W. Booth, and J. A. Ibdah. 2008. Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. Am. J. Physiol. Gastrointest. Liver Physiol. 294 : G619-G626.
16. Shen, L., A. Hillebrand, D. Q. Wang, and M. Liu. 2012. Isolation and primary culture of rat hepatic cells. J. Vis. Exp. (64) : 3917.
17. Moon, A., and W. J. Rhead. 1987. Complementation analysis of fatty acid oxidation disorders. J. Clin. Invest. 79 : 59-64.
18. Sleboda, J., K. A. Risan, O. Spydevold, and J. Bremer. 1999. Shortterm regulation of carnitine palmitoyltransferase I in cultured rat hepatocytes: Spontaneous inactivation and reactivation by fatty acids. Biochim. Biophys. Acta. 1436 : 541-549.
19. Shen, L., D. Q. Wang, C. M. Lo, P. Tso, W. S. Davidson, S. C. Woods, and M. Liu. 2010. Estradiol increases the anorectic effect of central apolipoprotein A-IV. Endocrinology. 151 : 3163-3168.
20. Shen, L., P. Tso, S. C. Woods, R. R. Sakai, W. S. Davidson, and M. Liu. 2007. Hypothalamic apolipoprotein A-IV is regulated by leptin. Endocrinology. 148 : 2681-2689.
21. Liu, H., Y. M. Jiang, Y. B. Luo, and W. B. Jiang. 2006. A simple and rapid determination of ATP, ADP and AMP concentrations in pericarp tissue of litchi fruit by high performance liquid chromatography. Food Technol. Biotechnol. 44 : 531-534.
22. Woods, A., S. R. Johnstone, K. Dickerson, F. C. Leiper, L. G. Fryer, D. Neumann, U. Schlattner, T. Wallimann, M. Carlson, and D. Carling. 2003. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13 : 2004-2008.
23. Suter, M., U. Riek, R. Tuerk, U. Schlattner, T. Wallimann, and D. Neumann. 2006. Dissecting the role of 5 ′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J. Biol. Chem. 281 : 32207-32216.
24. Tessari, P., A. Coracina, A. Cosma, and A. Tiengo. 2009. Hepatic lipid metabolism and non-alcoholic fatty liver disease. Nutr. Metab. Cardiovasc. Dis. 19 : 291-302.
25. Munday, M. R. 2002. Regulation of mammalian acetyl-CoA carboxylase. Biochem. Soc. Trans. 30 : 1059-1064.
26. Shimano, H. 2000. Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver. Trends Cardiovasc. Med. 10 : 275-278.
27. Ntambi, J. M. 1995. The regulation of stearoyl-CoA desaturase (SCD). Prog. Lipid Res. 34 : 139-150.
28. Finck, B. N., and D. P. Kelly. 2006. PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease. J. Clin. Invest. 116 : 615-622.
29. Vega, R. B., J. M. Huss, and D. P. Kelly. 2000. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 20 : 1868-1876.
30. Lee, S. S., T. Pineau, J. Drago, E. J. Lee, J. W. Owens, D. L. Kroetz, P. M. Fernandez-Salguero, H. Westphal, and F. J. Gonzalez. 1995. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15 : 3012-3022.
31. Kim, Y. I., S. Hirai, T. Goto, C. Ohyane, H. Takahashi, T. Tsugane, C. Konishi, T. Fujii, S. Inai, Y. Iijima, et al. 2012. Potent PPARalpha activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice. PLoS ONE. 7 : E31317.
32. Rakhshandehroo, M., G. Hooiveld, M. Muller, and S. Kersten. 2009. Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS ONE. 4 : E6796.