Ketamine induces motor neuron toxicity and alters neurogenic and proneural gene expression in zebrafish

Journal of Applied Toxicology

Volumn 33, Issue 6, 2013, Pages 410-417

  Kanungo, Jyotshna ^a   Cuevas, Elvis ^a   Ali, Syed F ^a   Paule, Merle G ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Gene expression; Ketamine; Motor neuron; Neurotoxicity; Transgenic zebrafish

Indexed keywords

GREEN FLUORESCENT PROTEIN; KETAMINE; NEUROGENIC DIFFERENTIATION FACTOR; NEUROGENIN 1; NOTCH1 RECEPTOR; NOTCH1A RECEPTOR; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI2A; TRANSCRIPTION FACTOR GLI2B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EXPOSURE; EMBRYO; GENE EXPRESSION REGULATION; IN VIVO STUDY; LARVA; MOTONEURON; NERVE CELL DIFFERENTIATION; NERVE FIBER; NERVE GROWTH; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC ANIMAL; UPREGULATION; ZEBRA FISH;

ANESTHETICS, DISSOCIATIVE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DNA PRIMERS; DNA, COMPLEMENTARY; EMBRYO, NONMAMMALIAN; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; KETAMINE; MOTOR NEURONS; REAL-TIME POLYMERASE CHAIN REACTION; RNA; SPINAL CORD; TRANSCRIPTION FACTORS; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO; MAMMALIA; PRIMATES; RODENTIA;

EID: 84876743132     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1751     Document Type: Article

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