Ketamine potentiates cerebrocortical damage induced by the common anaesthetic agent nitrous oxide in adult rats

British Journal of Pharmacology

Volumn 130, Issue 7, 2000, Pages 1692-1698

  Jevtovic Todorovic, Vesna ^a   Benshoff, Nicholas ^a   Olney, John W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anaesthesia; Drug interactions; GABA receptor; Ketamine; Laughing gas; Neurodegeneration; Nitrous oxide; NMDA receptor

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ANESTHETIC AGENT; DIAZEPAM; HALOTHANE; ISOFLURANE; KETAMINE; NITROUS OXIDE; PENTOBARBITAL; PSYCHEDELIC AGENT;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INJURY; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033864688     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703479     Document Type: Article

References (30)

1. BERGGREN, D., GUSTAFSON, Y., ERIKKSON, B., BUCHT, G., HANSSON, L.I., REIZ, S. & WINBLAD, B. (1987). Postoperative confusion after anesthesia in elderly patients with femoral neck fractures. Anest. Analg., 66, 497.
2. BOVILL, J.G., COPPELL, L., DUNDEE, J.W. & MOORE, J. (1971). Current status of ketamine anaesthesia. Lancet, 1, 1285.
3. DOHRN, C.S., LICHTOR, J.L., COALSON, D.W., VITVLUGT, A., deWIT & ZACNY, J.P. (1993). Reinforcing effects of extended inhalation of nitrous oxide in humans. Drug Alcohol Depend., 31, 265-280.
4. EDWARDS, R.P., MILLER, R.D., ROIZEN, M.F., HAM, J., WAY, W.L., LAKE, C.R. & RODERICK, L. (1979). Cardiac responses to imipramine and pancuronium during anesthesia with halothane or enflurane. Anesthesiology, 50, 421-425.
5. FIX, A.S., HORN, J.W., WIGHTMAN, K.A., JOHNSON, C.A., LONG, G.G., STORTS, R.W., FARBER, N., WOZNIAK, D.F. & OLNEY, J.W. (1993). Neuronal vacuolization and necrosis induced by the non-competitive N-methyl-D-aspartate (NMDA) antagonist MK (+)801 (Dizocilipine Maleate): A light and electron microscopic evaluation of the rat retrosplenial cortex. Exp. Neurol., 123, 204-215.
6. FRAGEN, R.J. & AVRAM, M.J. (1992). Nonopioid Intravenous Anesthetics. In Clinical Anesthesia, ed. Barash et al. pp 385-412. Philadelphia: JB Lippincott.
7. FRANKS, N.P. & LIEB, W.R. (1994). Molecular and cellular mechanism of general anesthesia. Nature, 367, 607-614.
8. GHONEIM, M.M. & LONG, J.P. (1970). The interaction between magnesium and other neuromuscular blocking agents. Anesthesiology, 32, 23-27.
9. GONSOWSKI, C.T. & EGER II, E.I. (1994). Nitrous oxide minimum alveolar anesthetic concentration in rats is greater than previously reported. Anesth. Anal., 79, 710-712.
10. GREEN, C.J., KNIGHT, J., PRECIOUS, S. & SIMPKIN, S. (1981). Ketamine alone and combined with diazepam or xylazine in laboratory animals: a 10 years experience. Laboratory Animals, 15, 163-170.
11. HORNBEIN, T.F., EGER II, E.I., WINTER, P.M., SMITH, G., WETSTONE, D. & SMITH, K.H. (1982). The minimum alveolar concentration of nitrous oxide in man. Anest. Analg., 61, 553-556.
12. ISHIMARU, M., FUKAMAUCHI, F. & OLNEY, J.W. (1995). Halothane prevents MK-801 neurotoxicity in the rat cingulate cortex. Neurosci. Lett., 193, 1-4.
13. JEVTOVIC-TODOROVIC, V., BENSHOFF, N. & OLNEY, J.W. (1998a). Prolonged nitrous oxide anesthesia kills neurons in the adult rate brain. J. Neurosurg. Anest., 10, 257.
14. JEVTOVIC-TODOROVIC, V., KIRBY, C.O. & OLNEY, J.W. (1997). Isoflurane and propofol block neurotoxicity caused by MK-801 in the rat posterior cingulate/retrosplenial cortex. J. Cereb. Flow Met., 17, 168-174.
15. JEVTOVIC-TODOROVIC, V., TODOROVIC, S.M., MENNERICK, S., POWELL, S., DIKRANIAN, K., BENSOFF, N., ZORUMSKI, C.F. & OLNEY, J.W. (1998b). Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nature Med., 4, 460-463.
16. KNOX, J.W.D., BOVILL, J.G., CLARKE, R.S.J. & DUNDEE, J.W. (1970). Clinical studies of induction agents. XXXVI: Ketamine. Br. J. Anaesth., 42, 875.
17. LIPOWSKl, Z.J. (1989). Delirium in the elderly patient. N. Engl. J. Med., 320, 578.
18. LODGE, D. & ANIS, N.A. (1982). Effects of phencyclidine on excitatory amino acid activation of spinal interneurons in the cat. Eur. J. Pharmacol., 77, 203-204.
19. MAGBAGBEOLA, J.A.O. & THOMAS, N.A. (1974). Effect of thiopentone on emergence reactions to ketamine anaesthesia. Canad. Anaest. Soc. J., 21, 321-324.
20. MENNERICK, S., JEVTOVIC-TODOROVIC, V., TODOROVIC, S.M., WEIXING, S., OLNEY, J.W. & ZORUMSKI, C.F. (1998). Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures. J. Neurosci., 18, 9716-9726.
21. OLNEY, J.W. & FARBER, N.B. (1995). NMDA antagonists as neurotherapeutic drugs, psychotogens, neurotoxins and research tools for studying schizophrenia. Neuropsychopharmacology, 13, 335-345.
22. OLNEY, J.W., LABRUYERE, J. & PRICE, M.T. (1989). Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science, 244, 1360-1362.
23. OLNEY, J.W., LABRUYERE, J., WANG, G., SESMA, M.A., WOZNIAK, D. & PRICE, M.T. (1991). NMDA antagonist neurotoxicity: Mechanism and protection. Science, 254, 1515-1518.
24. REICH, D.L. & SILVAY, G. (1989). Ketamine: an update on the first twenty years of clinical experience. Can. J. Anaesth., 36, 186-197.
25. SMITH, J.W., SEIDL, L.G. & JOHNSON, J.E. (1966). Studies on the epidemiology of adverse drug reactions. Ann. Int. Mad., 65, 629-640.
26. SMITH, N.J. & CORBASCIO, A.N. (1986). Drug Interactions in Anesthesia. Philadelphia: Lea & Febiger.
27. SOKOLL, M.D. & GERGIS, S.D. (1981). Antibiotics and neuromuscular function. Anesthesiohgy, 55, 148-159.
28. SONI, N. (1987). Mechanism of drug interactions. In Drugs in Anesthesia: Mechanism of Action, eds. Feldman SA, Scurr CF, Paton E. p. 408. Baltimore: Edward Arnold.
29. STEVENS, W.C. & KINGSTON, G.G. (1992). Inhalation Anesthesia. In Clinical Anesthesia., ed. Barash et al. pp 439-465. Philadelphia: JB Lippincott.
30. TALLARIDA, R.J., PORRECA, F. & COWAN, A. (1989). Statistical analysis of drug-drug and site-site interactions with isobolograms. Life Sciences, 45, 947-961.