Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo

Biochemical and Biophysical Research Communications

Volumn 386, Issue 1, 2009, Pages 263-267

  Kanungo, Jyotshnabala ^a   Zheng, Ya Li ^a   Amin, Niranjana D ^a   Kaur, Sukhbir ^b   Ramchandran, Ramani ^b,c   Pant, Harish C ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Morpholino knockdown; Motor neuron; Neurogenesis; Protein kinase; Zebrafish

Indexed keywords

CYCLIN DEPENDENT KINASE 5; PROTEIN P35; PROTEIN P39;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; MOTONEURON; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPINAL CORD MOTONEURON; SYNAPTIC TRANSMISSION; ZEBRA FISH;

ANIMALS; BRAIN; CYCLIN-DEPENDENT KINASE 5; EMBRYO, NONMAMMALIAN; GENE KNOCKDOWN TECHNIQUES; MOTOR NEURONS; NEUROGENESIS; OLIGONUCLEOTIDES, ANTISENSE; SPINAL CORD; ZEBRAFISH;

DANIO RERIO;

EID: 67649210729     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.06.038     Document Type: Article

References (32)

1. Hartenstein V. Early neurogenesis in Xenopus: the spatio-temporal pattern of proliferation and cell lineages in the embryonic spinal cord. Neuron 3 (1989) 399-411
2. Sasai Y., and De Robertis E.M. Ectodermal patterning in vertebrate embryos. Dev. Biol. 182 (1997) 5-20
3. Meyerson M., Enders G.H., Wu C.L., Su L.K., Gorka C., Nelson C., Harlow E., and Tsai L.H. A family of human cdc2-related protein kinases. EMBO J. 11 (1992) 2909-2917
4. Dhavan R., and Tsai L.H. A decade of CDK5. Nat. Rev. Mol. Cell Biol. 2 (2001) 749-759
5. Lew J., Huang Q.Q., Qi Z., Winkfein R.J., Aebersold R., Hunt T., and Wang J.H. A brain-specific activator of cyclin-dependent kinase 5. Nature 371 (1994) 423-426
6. Tsai L.H., Delalle I., Caviness Jr. V.S., Chae T., and Harlow E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371 (1994) 419-423
7. Zheng M., Leung C.L., and Liem R.K. Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system. J. Neurobiol. 35 (1998) 141-159
8. Ohshima T., Ward J.M., Huh C.G., Longenecker G., Veeranna, Pant H.C., Brady R.O., Martin L.J., and Kulkarni A.B. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl. Acad. Sci. USA 93 (1996) 11173-11178
9. Nikolic M., Dudek H., Kwon Y.T., Ramos Y.F., and Tsai L.H. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes Dev. 10 (1996) 816-825
10. Becker C.G., Lieberoth B.C., Morellini F., Feldner J., Becker T., and Schachner M. L1.1 is involved in spinal cord regeneration in adult zebrafish. J. Neurosci. 24 (2004) 7837-7842
11. Kanungo J., Li B.S., Goswami M., Zheng Y.L., Ramchandran R., and Pant H.C. Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5. Neurosci. Lett. 412 (2007) 233-238
12. Kanungo J., Li B.S., Zheng Y., and Pant H.C. Cyclin-dependent kinase 5 influences Rohon-Beard neuron survival in zebrafish. J. Neurochem. 99 (2006) 251-259
13. Higashijima S., Hotta Y., and Okamoto H. Visualization of cranial motor neurons in live transgenic zebrafish expressing green fluorescent protein under the control of the islet-1 promoter/enhancer. J. Neurosci. 20 (2000) 206-218
14. Nasevicius A., and Ekker S.C. Effective targeted gene 'knockdown' in zebrafish. Nat. Genet. 26 (2000) 216-220
15. Li B.S., Zhang L., Gu J., Amin N.D., and Pant H.C. Integrin alpha(1) beta(1)-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation. J. Neurosci. 20 (2000) 6055-6062
16. Kanungo J., Zheng Y.L., Mishra B., and Pant H.C. Zebrafish Rohon-Beard neuron development: Cdk5 in the midst. Neurochem. Res. 34 (2009) 1129-1137
17. Cicero S., and Herrup K. Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation. J. Neurosci. 25 (2005) 9658-9668
18. Connell-Crowley L., Le Gall M., Vo D.J., and Giniger E. The cyclin-dependent kinase Cdk5 controls multiple aspects of axon patterning in vivo. Curr. Biol. 10 (2000) 599-602
19. Smith D. Cdk5 in neuroskeletal dynamics. Neurosignals 12 (2003) 239-251
20. Tsai L.H., Takahashi T., Caviness Jr. V.S., and Harlow E. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 119 (1993) 1029-1040
21. Adolf B., Chapouton P., Lam C.S., Topp S., Tannhauser B., Strahle U., Gotz M., and Bally-Cuif L. Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon. Dev. Biol. 295 (2006) 278-293
22. Chapouton P., Adolf B., Leucht C., Tannhauser B., Ryu S., Driever W., and Bally-Cuif L. her5 expression reveals a pool of neural stem cells in the adult zebrafish midbrain. Development 133 (2006) 4293-4303
23. Grandel H., Kaslin J., Ganz J., Wenzel I., and Brand M. Neural stem cells and neurogenesis in the adult zebrafish brain: origin, proliferation dynamics, migration and cell fate. Dev. Biol. 295 (2006) 263-277
24. Zupanc G.K., Hinsch K., and Gage F.H. Proliferation, migration, neuronal differentiation, and long-term survival of new cells in the adult zebrafish brain. J. Comp. Neurol. 488 (2005) 290-319
25. Gould E. How widespread is adult neurogenesis in mammals?. Nat. Rev. Neurosci. 8 (2007) 481-488
26. Tsuchida T., Ensini M., Morton S.B., Baldassare M., Edlund T., Jessell T.M., and Pfaff S.L. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79 (1994) 957-970
27. William C.M., Tanabe Y., and Jessell T.M. Regulation of motor neuron subtype identity by repressor activity of Mnx class homeodomain proteins. Development 130 (2003) 1523-1536
28. Cheesman S.E., Layden M.J., Von Ohlen T., Doe C.Q., and Eisen J.S. Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation. Development 131 (2004) 5221-5232
29. Park H.C., Shin J., and Appel B. Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling. Development 131 (2004) 5959-5969
30. Bareyre F.M. Neuronal repair and replacement in spinal cord injury. J. Neurol. Sci. 265 (2008) 63-72
31. Pinto L., and Gotz M. Radial glial cell heterogeneity - the source of diverse progeny in the CNS. Prog. Neurobiol. 83 (2007) 2-23
32. Reimer M.M., Sorensen I., Kuscha V., Frank R.E., Liu C., Becker C.G., and Becker T. Motor neuron regeneration in adult zebrafish. J. Neurosci. 28 (2008) 8510-8516