Recombinant snake venom cystatin inhibits tumor angiogenesis in vitro and in vivo associated with downregulation of VEGF-A165, Flt-1 and bFGF

Anti-Cancer Agents in Medicinal Chemistry

Volumn 13, Issue 4, 2013, Pages 663-671

  Xie, Qun ^a,b   Tang, Nanhong ^a   Wan, Rong ^a   Qi, Yuanlin ^a   Lin, Xu ^a   Lin, Jianyin ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b PUTIAN UNIVERSITY   (China)

Author keywords

Angiogenesis; Basic fibroblast growth factor; Cystatin; Endothelial cell; Fms related tyrosine kinase 1; Snake venom; Vascular endothelial growth factor A165

Indexed keywords

CYSTATIN; FIBROBLAST GROWTH FACTOR 2; VASCULOTROPIN 165; VASCULOTROPIN RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY DENSITY; CELL ADHESION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MALE; MELANOMA; MOUSE; NONHUMAN; PROTEIN PURIFICATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; CELL PROLIFERATION; CYSTATINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FIBROBLAST GROWTH FACTOR 2; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; RECOMBINANT PROTEINS; SNAKE VENOMS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84876731619     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520611313040015     Document Type: Article

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