Inhibition of invasion and metastasis of MHCC97H cells by expression of snake venom cystatin through reduction of proteinases activity and Epithelial-Mesenchymal Transition

Archives of Pharmacal Research

Volumn 34, Issue 5, 2011, Pages 781-789

  Tang, Nanhong ^a   Xie, Qun ^a,b   Wang, Xiaoqian ^a   Li, Xiujin ^a   Chen, Yanlin ^a   Lin, Xu ^a   Lin, Jianyin ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b PUTIAN UNIVERSITY   (China)

Author keywords

Cystatin; Hepatocellular carcinoma; Invasion; Metastasis; Snake venom

Indexed keywords

CATHEPSIN B; COMPLEMENTARY DNA; CYSTATIN; GELATINASE A; GELATINASE B; MATRIGEL; PROTEINASE; SNAKE VENOM; SNAKE VENOM CYSTATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; LUNG METASTASIS; MOUSE; NONHUMAN;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CATHEPSIN B; CELL LINE, TUMOR; CELL MOVEMENT; CLONE CELLS; CYSTATINS; EPITHELIAL-MESENCHYMAL TRANSITION; GELATINASES; GENE SILENCING; GENE THERAPY; LIVER NEOPLASMS; LUNG NEOPLASMS; MALE; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; SNAKE VENOMS; TWIST TRANSCRIPTION FACTOR; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79960224984     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0512-6     Document Type: Article

References (33)

1. M. Alvarez-Fernandez A. J. Barrett B. Gerhartz P. M. Dando J. Ni M. Abrahamson 1999 Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site J. Biol. Chem. 274 19195 19203 10383426 10.1074/jbc.274.27.19195 1:CAS:528:DyaK1MXksVWlt7k%3D (Pubitemid 29314120)
2. A. J. Barrett 1980 Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates Biochem. J. 187 909 912 6897924 1:CAS:528:DyaL3cXlvVWmu7k%3D (Pubitemid 10017578)
3. M. Brillard-Bourdet V. Nguyên M. Ferrer-di Martino F. Gauthier T. Moreau 1998 Purification and characterization of a new cystatin inhibitor from Taiwan cobra (Naja naja atra) venom Biochem. J. 331 239 244 9512485 1:CAS:528:DyaK1cXisVWkt7o%3D (Pubitemid 28163980)
4. H. S. Chiang R. S. Yang T. F. Huang 1996 Thrombin enhances the adhesion and migration of human colon adenocarcinoma cells via increased beta-3 integrin expression on the tumour cell surface and their inhibition by the snake venom peptide, rhodostomin Br. J. Cancer 73 902 908 8611404 10.1038/bjc.1996.161 1:CAS:528:DyaK28XislKqs7g%3D
5. G. Deep R. Agarwal 2010 Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer Cancer Metastasis Rev. 29 447 463 20714788 10.1007/s10555-010-9237-0 1:CAS:528:DC%2BC3cXhtFWqt7rL
6. A. Fedorowski A. Steciwko J. Rabczyñski 2004 Serum cathepsin B activity during regression of Morris hepatoma 5123 D Med. Sci. Monit. 10 BR144 BR150 15114263
7. S. Grünert M. Jechlinger H. Beug 2003 Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis Nat. Rev. Mol. Cell Biol. 4 657 665 12923528 10.1038/nrm1175 (Pubitemid 36934968)
8. S. Hirohashi 1998 Inactivation of the E-cadherin-mediated cell adhesion system in human cancers Am. J. Pathol. 153 333 339 9708792 10.1016/S0002- 9440(10)65575-7 1:CAS:528:DyaK1cXls1ejsbw%3D (Pubitemid 28373643)
9. S. Iwai T. Nakanishi-Ueda D. Armstrong K. Oguchi 2008 Zymographical techniques for detection of matrix metalloproteinases Methods Mol. Biol. 477 113 121 19082943 10.1007/978-1-60327-517-0-10 1:CAS:528:DC%2BD1cXhtl2gtL3F
10. T. Kophengnavong J. E. Michnowicz T. K. Blackwell 2000 Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations Mol. Cell Biol. 20 261 272 10594029 10.1128/MCB.20.1.261-272.2000 1:CAS:528:DC%2BD3cXlt1Wn (Pubitemid 30002568)
11. T. T. Lah J. L. Clifford K. M. Helmer N. A. Day K. Moin K. V. Honn J. D. Crissman B. F. Sloane 1989 Inhibitory properties of low molecular mass cysteine proteinase inhibitors from human sarcoma Biochim. Biophys. Acta 993 63 73 2804124 1:CAS:528:DyaL1MXmtFalt70%3D (Pubitemid 19249311)
12. J. M. Lee S. Dedhar R. Kalluri E. W. Thompson 2006 The epithelial-mesenchymal transition: new insights in signaling, development, and disease J. Cell Biol. 172 973 981 16567498 10.1083/jcb.200601018 1:CAS:528:DC%2BD28XjtF2qsLs%3D
13. T. K. Lee R. T. Poon A. P. Yuen M. T. Ling W. K. Kwok X. H. Wang Y. C. Wong X. Y. Guan K. Man K. L. Chau S. T. Fan 2006 Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition Clin. Cancer Res. 12 5369 5376 17000670 10.1158/1078-0432.CCR-05-2722 1:CAS:528:DC%2BD28XpvFShsLw%3D (Pubitemid 44497250)
14. W. Li F. Ding L. Zhang Z. Liu Y. Wu A. Luo M. Wu M. Wang Q. Zhan Z. Liu 2005 Overexpression of stefin A in human esophageal squamous cell carcinoma cells inhibits tumor cell growth, angiogenesis, invasion, and metastasis Clin Cancer Res. 11 8753 8762 16361563 10.1158/1078-0432.CCR-05-0597 1:CAS:528:DC%2BD2MXhtlWrsbvL (Pubitemid 43005926)
15. C. Liu C. Sun H. Huang K. Janda T. Edgington 2003 Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy Cancer Res. 63 2957 2964 12782603 1:CAS:528:DC%2BD3sXkt1aitL8%3D (Pubitemid 36667169)
16. R. W. Mason D. L. Stabley G. N. Picerno J. Frenck S. Xing G. P. Bertenshaw K. Sol-Church 2002 Evolution of placental proteases Biol. Chem. 383 1113 1118 12437094 10.1515/BC.2002.120 1:CAS:528:DC%2BD38Xptl2itLg%3D (Pubitemid 35215056)
17. G. J. McKenna Y. Chen R. M. Smith A. Meneghetti C. Ong R. McMaster C. H. Scudamore S. W. Chung 2002 A role for matrix metalloproteinases and tumor host interaction in hepatocellular carcinomas Am. J. Surg. 183 588 594 12034400 10.1016/S0002-9610(02)00833-4 1:CAS:528:DC%2BD38XktVCit70%3D (Pubitemid 34603436)
18. M. M. Mohamed B. F. Sloane 2006 Cysteine cathepsins: multifunctional enzymes in cancer Nat. Rev. Cancer 6 764 775 16990854 10.1038/nrc1949 1:CAS:528:DC%2BD28XpvVCmu7Y%3D (Pubitemid 44450465)
19. A. Pavlova J. C. Krupa J. S. Mort M. Abrahamson I. Björk 2000 Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop. Demonstration by release of loop anchoring through mutation of his110 FEBS Lett. 487 156 160 11150500 10.1016/S0014-5793(00)02337-1 1:CAS:528:DC%2BD3MXisVSjtg%3D%3D (Pubitemid 32057104)
20. H. Peinado A. Cano 2006 New potential therapeutic targets to combat epithelial tumor invasion Clin. Transl. Oncol. 8 851 857 17169758 10.1007/s12094-006-0148-z 1:CAS:528:DC%2BD2sXmtV2lu74%3D
21. A. Premzl V. Turk J. Kos 2006 Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro J Cell Biochem. 97 1230 1240 16315320 10.1002/jcb.20720 1:CAS:528:DC%2BD28XjtFeqtLw%3D
22. R. Shridhar J. Zhang J. Song B. A. Booth C. G. Kevil G. Sotiropoulou B. F. Sloane D. Keppler 2004 Cystatin M suppresses the malignant phenotype of human MDAMB-435S cells Oncogene 23 2206 2215 14676833 10.1038/sj.onc.1207340 1:CAS:528:DC%2BD2cXitFCmsbY%3D (Pubitemid 38482535)
23. J. P. Sokol W. P. Schiemann C. Cystatin 2004 antagonizes transforming growth factor β signaling in normal and cancer cells Mol. Cancer Res. 2 183 195 15037657 1:CAS:528:DC%2BD2cXjtFWksbg%3D (Pubitemid 39030308)
24. J. Song R. Wan S. M. Weng X. Lin J. Y. Lin 2004 Gene synthesis of cystatin from snake venom and its expression in E. coil Fu Jian Yi Ke Da Xue Xue Bao 38 241 245
25. Z. Y. Tang 2005 Hepatocellular carcinoma surgery: review of the past and prospects for the 21st century J. Surg. Oncol. 91 95 96 16028278 10.1002/jso.20291 (Pubitemid 41077047)
26. B. Thisse M. el Messal F. Perrin-Schmitt 1987 The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern Nucleic Acids Res. 15 3439 3453 3106932 10.1093/nar/15.8.3439 1:CAS:528:DyaL2sXktFykt74%3D
27. J. Tian Z. Y. Tang S. L. Ye Y. K. Liu Z. Y. Lin J. Chen Q. Xue 1999 New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis Br. J. Cancer 81 814 821 10555751 10.1038/sj.bjc.6690769 1:CAS:528:DyaK1MXnsFGgtb8%3D (Pubitemid 29504690)
28. R. Wan H. Zheng J. Song X. Lin J. Y. Lin 2005 The studies on effect of snake venom cystatin for invasion and metastasis of the human gastric carcinoma cell line Chinese Journal of Clinical Oncology 32 961 965 1:CAS:528: DC%2BD28XntFChtbo%3D (Pubitemid 350042695)
29. R. Wan H.Y. Zheng J. Song S. M. Weng X. Lin J. Y. Lin 2006 The effect of cysteine protease inhibitor of snake venom (sv-cystatin) on mouse melanoma cells invasion in vitro and in vivo Jie Pou Xue Bao 37 640 645 1:CAS:528: DC%2BD1cXhtlemsrw%3D (Pubitemid 46139759)
30. J. Yang S. A. Mani J. L. Donaher S. Ramaswamy R. A. Itzykson C. Come P. Savagner I. Gitelman A. Richardson R. A. Weinberg 2004 Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis Cell 117 927 939 15210113 10.1016/j.cell.2004.06.006 1:CAS:528:DC%2BD2cXlsFWnu7w%3D (Pubitemid 38798858)
31. Z. Yang X. Zhang H. Gang X. Li Z. Li T. Wang J. Han T. Luo F. Wen X. Wu 2007 Up-regulation of gastric cancer cell invasion by Twist is accompanied by Ncadherin and fibronectin expression Biochem. Biophys. Res. Commun. 358 925 930 17512904 10.1016/j.bbrc.2007.05.023 1:CAS:528:DC%2BD2sXlvV2qt7c%3D (Pubitemid 46802478)
32. C. H. Yeh H. C. Peng R. S. Yang T. F. Huang 2001 Rhodostomin, a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective alpha(v)beta(3) blockade of endothelial cells Mol. Pharmacol. 59 1333 1342 11306719 1:CAS:528: DC%2BD3MXjt1aqurg%3D
33. B. Zhai H. X. Yan S. Q. Liu L. Chen M. C. Wu H. Y. Wang 2008 Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas World J. Gastroenterol. 14 5665 5673 18837082 10.3748/wjg.14.5665 1:CAS:528: DC%2BD1MXitVWnsbg%3D