Recombinant snake venom cystatin inhibits the growth, invasion and metastasis of B16F10 cells and MHCC97H cells in vitro and in vivo

Toxicon

Volumn 57, Issue 5, 2011, Pages 704-711

  Xie, Qun ^a,b   Tang, Nanhong ^a   Wan, Rong ^a   Qi, Yuanlin ^a   Lin, Xu ^a   Lin, Jianyin ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b PUTIAN UNIVERSITY   (China)

Author keywords

Expression; Inhibitory activity; Invasion; Metastasis; Purification; Snake venom cystatin

Indexed keywords

ANTINEOPLASTIC AGENT; MATRIGEL; PAPAIN; RECOMBINANT SNAKE VENOM CYSTATIN; SNAKE VENOM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B16F10 CELL; CANCER CELL; CANCER INVASION; CONTROLLED STUDY; DRUG MECHANISM; DRUG PURIFICATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INOCULATION; LUNG TUMOR; MALE; METASTASIS; METASTASIS INHIBITION; MHCC97H CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR VOLUME;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; COBRA VENOMS; COLLAGEN; CYSTATINS; DRUG COMBINATIONS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; IMMUNOBLOTTING; KINETICS; LAMININ; MICE; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PAPAIN; PICHIA; PROTEOGLYCANS; RECOMBINANT PROTEINS;

MUS; MUS MUSCULUS; PICHIA PASTORIS;

EID: 79953292887     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.02.002     Document Type: Article

References (21)

1. Amor-Mahjoub M., Suppini J.P., Gomez-Vrielyunck N., Ladjimi M. The effect of the hexahistidine-tag in the oligomerization of HSC70 constructs. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2006, 844:328-334.
2. Briggs J.J., Haugen M.H., Johansen H.T., Riker A.I., Abrahamson M., Fodstad Ø, Maelandsmo G.M., Solberg R. Cystatin E/M suppresses legumain activity and invasion of human melanoma. BMC. Cancer 2010, 10:17.
3. Brillard-Bourdet M., Nguyên V., Ferrer-di Martino M., Gauthier F., Moreau T. Purification and characterization of a new cystatin inhibitor from Taiwan cobra (Naja naja atra) venom. Biochem. J. 1998, 331:239-244.
4. El-Refael M.F., Sarkar N.H. Snake venom inhibits the growth of mouse mammary tumor cells in vitro and in vivo. Toxicon 2009, 54:33-41.
5. Ervin H., Cox J.L. Late stage inhibition of hematogenous melanoma metastasis by cystatin C over-expression. Cancer Cell. Int. 2005, 5:14.
6. Evangelista I.L., Martins A.M., Nascimento N.R., Havt A., Evangelista J.S., de Norões T.B., Toyama M.H., Diz-Filho E.B., Toyama Dde O., Fonteles M.C., Monteiro H.S. Renal and cardiovascular effects of Bothrops marajoensis venom and phospholipase A2. Toxicon 2010, 55:1061-1070.
7. Evans H.J., Barrett A.J. A cystatin-like cysteine proteinase inhibitor from venom of the African puff adder (Bitis arietans). Biochem. J. 1987, 246:795-797.
8. Gil-Ad I., Shtaif B., Levkovitz Y., Nordenberg J., Taler M., Korov I., Weizman A. Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth. Oncol. Rep. 2006, 15:107-112.
9. Hoedemaeker F.J., Signorelli T., Johns K., Kuntz D.A., Rose D.R. A single chain Fv fragment of P-glycoprotein-specific monoclonal antibody C219. Design, Expression, and Crystal Structure at 2.4 A resolution. J. Biol. Chem. 1997, 272:29784-29789.
10. Muehlenweg B., Assfalg-Machleidt I., Parrado S.G., Bürgle M., Creutzburg S., Schmitt M., Auerswald E.A., Machleidt W., Magdolen V. A novel type of bifunctional inhibitor directed against proteolytic activity and receptor/ligand interaction. Cystatin with a Urokinase Receptor Binding Site. J. Biol. Chem. 2000, 275:33562-33566.
11. Ni J., Abrahamson M., Zhang M., Fernandez M.A., Grubb A., Su J., Yu G.L., Li Y., Parmelee D., Xing L., Coleman T.A., Gentz S., Thotakura R., Nguyen N., Hesselberg M., Gentz R. Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins. J. Biol. Chem. 1997, 272:10853-10858.
12. Redzynia I., Ljunggren A., Abrahamson M., Mort J.S., Krupa J.C., Jaskolski M., Bujacz G. Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B. J. Biol. Chem. 2008, 283:22815-22825.
13. Shridhar R., Zhang J., Song J., Booth B.A., Kevil C.G., Sotiropoulou G., Sloane B.F., Keppler D. Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells. Oncogene 2004, 23:2206-2215.
14. Shumiao Z., Huang J., Zhang C., Deng L., Hu N., Liang Y. High-level expression of an Aspergillus niger endo-beta-1,4-glucanase in Pichia pastoris through gene codon optimization and synthesis. J. Microbiol. Biotechnol. 2010, 20:467-473.
15. Sloane B.F., Yan S., Podgorski I., Linebaugh B.E., Cher M.L., Mai J., Cavallo-Medved D., Sameni M., Dosescu J., Moin K. Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment. Semin. Cancer Biol. 2005, 15:149-157.
16. Song J., Jie C., Polk P., Shridhar R., Clair T., Zhang J., Yin L., Keppler D. The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotoxin. Biochem. Biophys. Res. Commun. 2006, 340:175-182.
17. Song J., Wan R., Weng S.M., Lin X., Lin J.Y. Gene synthesis of cystatin from snake venom and its expression in E. coli. Fu. Jian. Yi Ke. Da. Xue Xue Bao 2004, 38:241-245. (Chinese).
18. Tu S.P., Jiang X.H., Lin M.C., Cui J.T., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan A.O., Yuen M.F., Lam S.K., Kung H.F., Wong B.C. Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer. Cancer Res. 2003, 63:7724-7732.
19. Wan R., Zheng H.Y., Song J., Lin X., Lin J.Y. The studies on effect of snake venom cystatin for invasion and metastasis of the human gastric carcinoma cell line. Zhong. Guo. Zhong. Liu. Lin. Chuang 2005, 32:961-965. (Chinese).
20. Wan R., Zheng H.Y., Song J., Weng S.M., Lin X., Lin J.Y. The effect of cysteine protease inhibitor of snake venom (sv-cystatin) on mouse melanoma cells invasion in vitro and in vivo. Jie. Pou. Xue Bao 2006, 37:640-645. (Chinese).
21. Xie Q., Wan R., Lin X., Lin J.Y. Effects of snake venom cystatin gene on gene expression profiles in mouse melanoma cell line B16F10. Ai. Zheng 2008, 27:716-722.