메뉴 건너뛰기




Volumn 17, Issue , 2013, Pages 23-32

Effect of long-term laboratory propagation on Chlamydia trachomatis genome dynamics

Author keywords

Adaptation; Chlamydia trachomatis; Evolution; In vitro propagation; Mutation; Selective advantage

Indexed keywords

ARTICLE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL REPRODUCTION; BACTERIAL STRAIN; BACTERIUM ISOLATE; CHLAMYDIA TRACHOMATIS; CONTROLLED STUDY; DNA SEQUENCE; EVOLUTIONARY ADAPTATION; GENE LOCATION; GENE SEQUENCE; GENOME ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MOLECULAR CLONING; MUTATION RATE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REPRODUCTIVE FITNESS; TRANSCRIPTION REGULATION;

EID: 84876718480     PISSN: 15671348     EISSN: 15677257     Source Type: Journal    
DOI: 10.1016/j.meegid.2013.03.035     Document Type: Article
Times cited : (28)

References (68)
  • 1
    • 0030032923 scopus 로고    scopus 로고
    • Muller's ratchet decreases fitness of a DNA-based microbe
    • Andersson D.I., Hughes D. Muller's ratchet decreases fitness of a DNA-based microbe. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:906-907.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 906-907
    • Andersson, D.I.1    Hughes, D.2
  • 4
    • 21244468526 scopus 로고    scopus 로고
    • Frequency of spontaneous mutations that confer antibiotic resistance in Chlamydia spp
    • Binet R., Maurelli A.T. Frequency of spontaneous mutations that confer antibiotic resistance in Chlamydia spp. Antimicrob. Agents Chemother. 2005, 49:2865-2873.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 2865-2873
    • Binet, R.1    Maurelli, A.T.2
  • 5
    • 79958039192 scopus 로고    scopus 로고
    • Loss of plasmids of Borrelia burgdorferi sensu lato during prolonged in vitro cultivation
    • Biškup U.G., Strle F., Ružić-Sabljić E. Loss of plasmids of Borrelia burgdorferi sensu lato during prolonged in vitro cultivation. Plasmid 2011, 66:1-6.
    • (2011) Plasmid , vol.66 , pp. 1-6
    • Biškup, U.G.1    Strle, F.2    Ružić-Sabljić, E.3
  • 7
    • 84869132655 scopus 로고    scopus 로고
    • Directional evolution of Chlamydia trachomatis towards niche-specific adaptation
    • Borges V., Nunes A., Ferreira R., Borrego M.J., Gomes J.P. Directional evolution of Chlamydia trachomatis towards niche-specific adaptation. J. Bacteriol. 2012, 194:6143-6153.
    • (2012) J. Bacteriol. , vol.194 , pp. 6143-6153
    • Borges, V.1    Nunes, A.2    Ferreira, R.3    Borrego, M.J.4    Gomes, J.P.5
  • 8
    • 0034691053 scopus 로고    scopus 로고
    • Effects of passage history and sampling bias on phylogenetic reconstruction of human influenza A evolution
    • Bush R.M., Smith C.B., Cox N.J., Fitch W.M. Effects of passage history and sampling bias on phylogenetic reconstruction of human influenza A evolution. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:6974-6980.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 6974-6980
    • Bush, R.M.1    Smith, C.B.2    Cox, N.J.3    Fitch, W.M.4
  • 9
    • 0019514724 scopus 로고
    • Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis
    • Caldwell H.D., Kromhout J., Schachter J. Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect. Immun. 1981, 31:1161-1176.
    • (1981) Infect. Immun. , vol.31 , pp. 1161-1176
    • Caldwell, H.D.1    Kromhout, J.2    Schachter, J.3
  • 10
    • 25444493846 scopus 로고    scopus 로고
    • Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains
    • Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D. Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains. Infect. Immun. 2005, 73:6407-6418.
    • (2005) Infect. Immun. , vol.73 , pp. 6407-6418
    • Carlson, J.H.1    Porcella, S.F.2    McClarty, G.3    Caldwell, H.D.4
  • 12
    • 0029096611 scopus 로고
    • Comparison of the Amplicor Chlamydia trachomatis test and cell culture for the detection of urogenital chlamydial infections
    • Catry M.A., Borrego M.J., Cardoso J., Azevedo J., Santo I. Comparison of the Amplicor Chlamydia trachomatis test and cell culture for the detection of urogenital chlamydial infections. Genitourin. Med. 1995, 71:247-250.
    • (1995) Genitourin. Med. , vol.71 , pp. 247-250
    • Catry, M.A.1    Borrego, M.J.2    Cardoso, J.3    Azevedo, J.4    Santo, I.5
  • 13
    • 79960104605 scopus 로고    scopus 로고
    • Microbial laboratory evolution in the era of genome-scale science
    • Conrad T.M., Lewis N.E., Palsson B.Ø. Microbial laboratory evolution in the era of genome-scale science. Mol. Syst. Biol. 2011, 7:509.
    • (2011) Mol. Syst. Biol. , vol.7 , pp. 509
    • Conrad, T.M.1    Lewis, N.E.2    Palsson, B.Ø.3
  • 14
    • 0037417962 scopus 로고    scopus 로고
    • Parallel changes in gene expression after 20,000 generations of evolution in Escherichia coli
    • Cooper T.F., Rozen D.E., Lenski R.E. Parallel changes in gene expression after 20,000 generations of evolution in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:1072-1077.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 1072-1077
    • Cooper, T.F.1    Rozen, D.E.2    Lenski, R.E.3
  • 15
    • 79959845500 scopus 로고    scopus 로고
    • The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites
    • Derré I., Swiss R., Agaisse H. The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites. PLoS Pathog. 2011, 7:e1002092.
    • (2011) PLoS Pathog. , vol.7
    • Derré, I.1    Swiss, R.2    Agaisse, H.3
  • 16
    • 84860663163 scopus 로고    scopus 로고
    • Evolutionary insight from whole-genome sequencing of experimentally evolved microbes
    • Dettman J.R., Rodrigue N., Melnyk A.H., Wong A., Bailey S.F., Kassen R. Evolutionary insight from whole-genome sequencing of experimentally evolved microbes. Mol. Ecol. 2012, 21:2058-2077.
    • (2012) Mol. Ecol. , vol.21 , pp. 2058-2077
    • Dettman, J.R.1    Rodrigue, N.2    Melnyk, A.H.3    Wong, A.4    Bailey, S.F.5    Kassen, R.6
  • 18
    • 0038441327 scopus 로고    scopus 로고
    • Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation
    • Elena S.F., Lenski R.E. Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation. Nat. Rev. Genet. 2003, 4:457-469.
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 457-469
    • Elena, S.F.1    Lenski, R.E.2
  • 19
    • 0030940821 scopus 로고    scopus 로고
    • Characterization of a new isolate of Chlamydia trachomatis which lacks the common plasmid and has properties of biovar trachoma
    • Farencena A., Comanducci M., Donati M., Ratti G., Cevenini R. Characterization of a new isolate of Chlamydia trachomatis which lacks the common plasmid and has properties of biovar trachoma. Infect. Immun. 1997, 65:2965-2969.
    • (1997) Infect. Immun. , vol.65 , pp. 2965-2969
    • Farencena, A.1    Comanducci, M.2    Donati, M.3    Ratti, G.4    Cevenini, R.5
  • 20
    • 0016110957 scopus 로고
    • The evolutionary advantage of recombination
    • Felsenstein J. The evolutionary advantage of recombination. Genetics 1974, 78:737-756.
    • (1974) Genetics , vol.78 , pp. 737-756
    • Felsenstein, J.1
  • 21
    • 25844495901 scopus 로고    scopus 로고
    • Parallel adaptive evolution cultures of Escherichia coli lead to convergent growth phenotypes with different gene expression states
    • Fong S.S., Joyce A.R., Palsson B.Ø. Parallel adaptive evolution cultures of Escherichia coli lead to convergent growth phenotypes with different gene expression states. Genome Res. 2005, 15:1365-1372.
    • (2005) Genome Res. , vol.15 , pp. 1365-1372
    • Fong, S.S.1    Joyce, A.R.2    Palsson, B.Ø.3
  • 22
    • 2542583245 scopus 로고    scopus 로고
    • The fate of competing beneficial mutations in an asexual population
    • Gerrish P.J., Lenski R.E. The fate of competing beneficial mutations in an asexual population. Genetica 1998, 102-103:127-144.
    • (1998) Genetica , pp. 127-144
    • Gerrish, P.J.1    Lenski, R.E.2
  • 23
    • 84890560903 scopus 로고    scopus 로고
    • Genomic stability of genotyping markers in Chlamydia trachomatis
    • Gomes J.P. Genomic stability of genotyping markers in Chlamydia trachomatis. Front. Cell. Infect. Microbiol. 2012, 2:77.
    • (2012) Front. Cell. Infect. Microbiol. , vol.2 , pp. 77
    • Gomes, J.P.1
  • 29
    • 14744268017 scopus 로고    scopus 로고
    • Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis
    • Kutlin A., Kohlhoff S., Roblin P., Hammerschlag M.R., Riska P. Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis. Antimicrob. Agents Chemother. 2005, 49:903-907.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 903-907
    • Kutlin, A.1    Kohlhoff, S.2    Roblin, P.3    Hammerschlag, M.R.4    Riska, P.5
  • 31
    • 33748804678 scopus 로고    scopus 로고
    • The effect of penicillin on Chlamydia trachomatis DNA replication
    • Lambden P.R., Pickett M.A., Clarke I.N. The effect of penicillin on Chlamydia trachomatis DNA replication. Microbiology 2006, 152:2573-2578.
    • (2006) Microbiology , vol.152 , pp. 2573-2578
    • Lambden, P.R.1    Pickett, M.A.2    Clarke, I.N.3
  • 32
    • 77954265373 scopus 로고    scopus 로고
    • Adaptive evolution of Escherichia coli K-12 MG1655 during growth on a Nonnative carbon source, L-1,2-propanediol
    • Lee D.H., Palsson B.Ø. Adaptive evolution of Escherichia coli K-12 MG1655 during growth on a Nonnative carbon source, L-1,2-propanediol. Appl. Environ. Microbiol. 2010, 76:4158-4168.
    • (2010) Appl. Environ. Microbiol. , vol.76 , pp. 4158-4168
    • Lee, D.H.1    Palsson, B.Ø.2
  • 33
    • 0019156922 scopus 로고
    • Polypeptidic composition analysis of "Chlamydia" purified elementary bodies by polyacrylamide slab gel electrophoresis (author's transl)
    • Lefebvre J.F., Orfila J. Polypeptidic composition analysis of "Chlamydia" purified elementary bodies by polyacrylamide slab gel electrophoresis (author's transl). Ann. Microbiol. (Paris) 1980, 131B:223-237.
    • (1980) Ann. Microbiol. (Paris) , vol.131 B , pp. 223-237
    • Lefebvre, J.F.1    Orfila, J.2
  • 34
    • 0030950412 scopus 로고    scopus 로고
    • Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus
    • Martínez M.A., Verdaguer N., Mateu M.G., Domingo E. Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:6798-6802.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 6798-6802
    • Martínez, M.A.1    Verdaguer, N.2    Mateu, M.G.3    Domingo, E.4
  • 35
    • 0032876437 scopus 로고    scopus 로고
    • Development of a quantitative gene expression assay for Chlamydia trachomatis identified temporal expression of sigma factors
    • Mathews S.A., Volp K.M., Timms P. Development of a quantitative gene expression assay for Chlamydia trachomatis identified temporal expression of sigma factors. FEBS Lett. 1999, 458:354-358.
    • (1999) FEBS Lett. , vol.458 , pp. 354-358
    • Mathews, S.A.1    Volp, K.M.2    Timms, P.3
  • 36
    • 73349133007 scopus 로고    scopus 로고
    • Thioredoxins and glutaredoxins: unifying elements in redox biology
    • Meyer Y., Buchanan B.B., Vignols F., Reichheld J.P. Thioredoxins and glutaredoxins: unifying elements in redox biology. Annu. Rev. Genet. 2009, 43:335-367.
    • (2009) Annu. Rev. Genet. , vol.43 , pp. 335-367
    • Meyer, Y.1    Buchanan, B.B.2    Vignols, F.3    Reichheld, J.P.4
  • 39
    • 50549201557 scopus 로고
    • The relation of recombination to mutational advance
    • Muller H.J. The relation of recombination to mutational advance. Mutat. Res. 1964, 106:2-9.
    • (1964) Mutat. Res. , vol.106 , pp. 2-9
    • Muller, H.J.1
  • 40
    • 84856372043 scopus 로고    scopus 로고
    • Virulence determinants in the obligate intracellular pathogen Chlamydia trachomatis revealed by forward genetic approaches
    • Nguyen B.D., Valdivia R.H. Virulence determinants in the obligate intracellular pathogen Chlamydia trachomatis revealed by forward genetic approaches. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:1263-1268.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 1263-1268
    • Nguyen, B.D.1    Valdivia, R.H.2
  • 41
    • 33745257019 scopus 로고    scopus 로고
    • A plasmid-cured Chlamydia muridarum strain displays altered plaque morphology and reduced infectivity in cell culture
    • O'Connell C.M., Nicks K.M. A plasmid-cured Chlamydia muridarum strain displays altered plaque morphology and reduced infectivity in cell culture. Microbiology 2006, 152:1601-1607.
    • (2006) Microbiology , vol.152 , pp. 1601-1607
    • O'Connell, C.M.1    Nicks, K.M.2
  • 43
    • 84870381715 scopus 로고    scopus 로고
    • Developmental stage-specific metabolic and transcriptional activity of Chlamydia trachomatis in an axenic medium
    • Omsland A., Sager J., Nair V., Sturdevant D.E., Hackstadt T. Developmental stage-specific metabolic and transcriptional activity of Chlamydia trachomatis in an axenic medium. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:19781-19785.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 19781-19785
    • Omsland, A.1    Sager, J.2    Nair, V.3    Sturdevant, D.E.4    Hackstadt, T.5
  • 45
    • 0025315592 scopus 로고
    • The 7.5-kb plasmid present in Chlamydia trachomatis is not essential for the growth of this microorganism
    • Peterson E.M., Markoff B.A., Schachter J., de la Maza L.M. The 7.5-kb plasmid present in Chlamydia trachomatis is not essential for the growth of this microorganism. Plasmid 1990, 23:144-148.
    • (1990) Plasmid , vol.23 , pp. 144-148
    • Peterson, E.M.1    Markoff, B.A.2    Schachter, J.3    de la Maza, L.M.4
  • 47
    • 37549051319 scopus 로고    scopus 로고
    • Variation in the mutation frequency determining quinolone resistance in Chlamydia trachomatis serovars L2 and D
    • Rupp J., Solbach W., Gieffers J. Variation in the mutation frequency determining quinolone resistance in Chlamydia trachomatis serovars L2 and D. J. Antimicrob. Chemother. 2008, 61:91-94.
    • (2008) J. Antimicrob. Chemother. , vol.61 , pp. 91-94
    • Rupp, J.1    Solbach, W.2    Gieffers, J.3
  • 50
    • 0014568254 scopus 로고
    • Lymphogranuloma venereum II. Characterization of some recently isolated strains
    • Schachter J., Meyer K.F. Lymphogranuloma venereum II. Characterization of some recently isolated strains. J. Bacteriol. 1969, 99:636-638.
    • (1969) J. Bacteriol. , vol.99 , pp. 636-638
    • Schachter, J.1    Meyer, K.F.2
  • 52
    • 0034542564 scopus 로고    scopus 로고
    • The evolution of mutation rates: separating causes from consequences
    • Sniegowski P.D., Gerrish P.J., Johnson T., Shaver A. The evolution of mutation rates: separating causes from consequences. Bioessays 2000, 22:1057-1066.
    • (2000) Bioessays , vol.22 , pp. 1057-1066
    • Sniegowski, P.D.1    Gerrish, P.J.2    Johnson, T.3    Shaver, A.4
  • 55
    • 73449104573 scopus 로고    scopus 로고
    • Compensatory evolution of gene regulation in response to stress by Escherichia coli lacking RpoS
    • Stoebel D.M., Hokamp K., Last M.S., Dorman C.J. Compensatory evolution of gene regulation in response to stress by Escherichia coli lacking RpoS. PLoS Genet. 2009, 5:e1000671.
    • (2009) PLoS Genet. , vol.5
    • Stoebel, D.M.1    Hokamp, K.2    Last, M.S.3    Dorman, C.J.4
  • 56
    • 0031724955 scopus 로고    scopus 로고
    • Effect of serial passage in tissue culture on sequence of omp1 from Chlamydia trachomatis clinical isolates
    • Stothard D.R., Van Der Pol B., Smith N.J., Jones R.B. Effect of serial passage in tissue culture on sequence of omp1 from Chlamydia trachomatis clinical isolates. J. Clin. Microbiol. 1998, 36:3686-3688.
    • (1998) J. Clin. Microbiol. , vol.36 , pp. 3686-3688
    • Stothard, D.R.1    Van Der Pol, B.2    Smith, N.J.3    Jones, R.B.4
  • 58
    • 20344365324 scopus 로고    scopus 로고
    • A directed screen for chlamydial proteins secreted by a type III mechanism identifies a translocated protein and numerous other new candidates
    • Subtil A., Delevoye C., Balañá M.E., Tastevin L., Perrinet S., Dautry-Varsat A. A directed screen for chlamydial proteins secreted by a type III mechanism identifies a translocated protein and numerous other new candidates. Mol. Microbiol. 2005, 56:1636-1647.
    • (2005) Mol. Microbiol. , vol.56 , pp. 1636-1647
    • Subtil, A.1    Delevoye, C.2    Balañá, M.E.3    Tastevin, L.4    Perrinet, S.5    Dautry-Varsat, A.6
  • 59
    • 14744277285 scopus 로고    scopus 로고
    • Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil
    • Suchland R.J., Bourillon A., Denamur E., Stamm W.E., Rothstein D.M. Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil. Antimicrob. Agents Chemother. 2005, 49:1120-1126.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 1120-1126
    • Suchland, R.J.1    Bourillon, A.2    Denamur, E.3    Stamm, W.E.4    Rothstein, D.M.5
  • 60
    • 57349113738 scopus 로고    scopus 로고
    • Identification of concomitant infection with Chlamydia trachomatis IncA-negative mutant and wild-type strains by genomic, transcriptional, and biological characterizations
    • Suchland R.J., Jeffrey B.M., Xia M., Bhatia A., Chu H.G., Rockey D.D., Stamm W.E. Identification of concomitant infection with Chlamydia trachomatis IncA-negative mutant and wild-type strains by genomic, transcriptional, and biological characterizations. Infect. Immun. 2008, 76:5438-5446.
    • (2008) Infect. Immun. , vol.76 , pp. 5438-5446
    • Suchland, R.J.1    Jeffrey, B.M.2    Xia, M.3    Bhatia, A.4    Chu, H.G.5    Rockey, D.D.6    Stamm, W.E.7
  • 61
    • 0031902829 scopus 로고    scopus 로고
    • CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization
    • Sullivan N., Sun Y., Sattentau Q., Thali M., Wu D., Denisova G., Gershoni J., Robinson J., Moore J., Sodroski J. CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization. J. Virol. 1998, 72:4694-4703.
    • (1998) J. Virol. , vol.72 , pp. 4694-4703
    • Sullivan, N.1    Sun, Y.2    Sattentau, Q.3    Thali, M.4    Wu, D.5    Denisova, G.6    Gershoni, J.7    Robinson, J.8    Moore, J.9    Sodroski, J.10
  • 62
    • 0000338235 scopus 로고
    • Studies on the etiology of trachoma with special reference to isolation of the virus in chick embryo
    • Tang F.F., Chang H.L., Huang Y.T., Wang K.C. Studies on the etiology of trachoma with special reference to isolation of the virus in chick embryo. Chin. Med. J. 1957, 75:429-447.
    • (1957) Chin. Med. J. , vol.75 , pp. 429-447
    • Tang, F.F.1    Chang, H.L.2    Huang, Y.T.3    Wang, K.C.4
  • 65
    • 84867043760 scopus 로고    scopus 로고
    • Comparative transcriptional analysis of homologous pathogenic and non-pathogenic Lawsonia intracellularis isolates in infected porcine cells
    • Vannucci F.A., Foster D.N., Gebhart C.J. Comparative transcriptional analysis of homologous pathogenic and non-pathogenic Lawsonia intracellularis isolates in infected porcine cells. PLoS One 2012, 7:e46708.
    • (2012) PLoS One , vol.7
    • Vannucci, F.A.1    Foster, D.N.2    Gebhart, C.J.3
  • 66
    • 0002027029 scopus 로고
    • A new evolutionary law
    • Van Valen L. A new evolutionary law. Evol. Theory 1973, 1:1-30.
    • (1973) Evol. Theory , vol.1 , pp. 1-30
    • Van Valen, L.1
  • 67
    • 80053440375 scopus 로고    scopus 로고
    • Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector
    • Wang Y., Kahane S., Cutcliffe L.T., Skilton R.J., Lambden P.R., Clarke I.N. Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector. PLoS Pathog. 2011, 7:e1002258.
    • (2011) PLoS Pathog. , vol.7
    • Wang, Y.1    Kahane, S.2    Cutcliffe, L.T.3    Skilton, R.J.4    Lambden, P.R.5    Clarke, I.N.6
  • 68
    • 14844363079 scopus 로고    scopus 로고
    • The number of mutations selected during adaptation in a laboratory population of Saccharomyces cerevisiae
    • Zeyl C. The number of mutations selected during adaptation in a laboratory population of Saccharomyces cerevisiae. Genetics 2005, 169:1825-1831.
    • (2005) Genetics , vol.169 , pp. 1825-1831
    • Zeyl, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.