Developmental stage-specific metabolic and transcriptional activity of Chlamydia trachomatis in an axenic medium

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 48, 2012, Pages 19781-19785

  Omsland, Anders ^a   Sager, Janet ^a   Nair, Vinod ^a   Sturdevant, Daniel E ^a   Hackstadt, Ted ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Intracellular parasite; Metabolism; Transcription

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE 6 PHOSPHATE;

ARTICLE; BIOSYNTHESIS; CELL FREE SYSTEM; CELL TYPE; CHLAMYDIA TRACHOMATIS; ELEMENTARY BODY; ENERGY RESOURCE; GENE EXPRESSION; GENETIC ASSOCIATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RETICULATE BODY;

CHLAMYDIA TRACHOMATIS; CULTURE MEDIA; MICROSCOPY, ELECTRON, TRANSMISSION; PROTEIN BIOSYNTHESIS; TRANSCRIPTION, GENETIC;

CHLAMYDIA TRACHOMATIS; CHLAMYDIAE;

EID: 84870381715     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212831109     Document Type: Article

References (36)

1. Burton MJ, Mabey DC (2009) The global burden of trachoma: A review. PLoS Negl Trop Dis 3:e460.
2. Brunham RC, Rey-Ladino J (2005) Immunology of Chlamydia infection: Implications for a Chlamydia trachomatis vaccine. Nat Rev Immunol 5:149-161.
3. Unemo M, Clarke IN (2011) The Swedish new variant of Chlamydia trachomatis. Curr Opin Infect Dis 24:62-69.
4. Shaw EI, et al. (2000) Three temporal classes of gene expression during the Chlamydia trachomatis developmental cycle. Mol Microbiol 37(4):913-925.
5. Hatch TP, Al-Hossainy E, Silverman JA (1982) Adenine nucleotide and lysine transport in Chlamydia psittaci. J Bacteriol 150:662-670.
6. Hatch TP, Miceli M, Silverman JA (1985) Synthesis of protein in host-free reticulate bodies of Chlamydia psittaci and Chlamydia trachomatis. J Bacteriol 162:938-942.
7. Weiss E, Wilson NN (1969) Role of exogenous adenosine triphosphate in catabolic and synthetic activities of Chlamydia psittaci. J Bacteriol 97:719-724.
8. Stephens RS, et al. (1998) Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 282:754-759.
9. Iliffe-Lee ER, McClarty G (1999) Glucose metabolism in Chlamydia trachomatis: The "energy parasite" hypothesis revisited. Mol Microbiol 33:177-187.
10. Haider S, et al. (2010) Raman microspectroscopy reveals long-term extracellular activity of Chlamydiae. Mol Microbiol 77:687-700.
11. Tipples G, McClarty G (1993) The obligate intracellular bacterium Chlamydia trachomatis is auxotrophic for three of the four ribonucleoside triphosphates. Mol Microbiol 8:1105-1114.
12. Hatch TP (1975) Competition between Chlamydia psittaci and L cells for host isoleucine pools: A limiting factor in chlamydial multiplication. Infect Immun 12: 211-220.
13. Derre I, Swiss R, Agaisse H (2011) The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites. PLoS Pathog 7:e1002092.
14. Wylie JL, Hatch GM, McClarty G (1997) Host cell phospholipids are trafficked to and then modified by Chlamydia trachomatis. J Bacteriol 179:7233-7242.
15. Cocchiaro J, Kumar Y, Fischer ER, Hackstadt T, Valdivia RH (2008) Cytoplasmic lipid droplets are translocatedd into the lumen of the Chlamydia trachomatis parasitophorous vacuole. Proc Natl Acad Sci USA 105(27):9379-9384.
16. Beatty WL (2006) Trafficking from CD63-positive late endocytic multivesicular bodies is essential for intracellular development of Chlamydia trachomatis. J Cell Sci 119:350-359.
17. Hackstadt T, Scidmore MA, Rockey DD (1995) Lipid metabolism in Chlamydia trachomatis-infected cells:directed trafficking of Golgi-derived sphingolipids to the chlamydial inclusion. Proc Natl Acad Sci USA 92:4877-4881.
18. Carabeo RA, Mead DJ, Hackstadt T (2003) Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion. Proc Natl Acad Sci USA 100:6771-6776.
19. Elwell CA, et al. (2011) Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. PLoS Pathog 7:e1002198.
20. Caldwell HD, Kromhout J, Schachter J (1981) Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect Immun 31:1161-1176.
21. Hackstadt T, Todd WJ, Caldwell HD (1985) Disulfide-mediated interactions of the chlamydial major outer membrane protein: Role in the differentiation of chlamydiae? J Bacteriol 161:25-31.
22. Heinzen RA, Hackstadt T (1997) The Chlamydia trachomatis parasitophorous vacuolar membrane is not passively permeable to low-molecular-weight compounds. Infect Immun 65:1088-1094.
23. Grieshaber S, Swanson JA, Hackstadt T (2002) Determination of the physical environment within the Chlamydia trachomatis inclusion using ion-selective ratiometric probes. Cell Microbiol 4(5):273-283.
24. Weiss E (1965) Adenosine triphosphate and other requirements for the utilization of glucose by agents of the psittacosis-trachoma group. J Bacteriol 90:243-253.
25. Bavoil P, Ohlin A, Schachter J (1984) Role of disulfide bonding in outer membrane structure and permeability in Chlamydia trachomatis. Infect Immun 44:479-485.
26. Belland RJ, et al. (2003) Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis. Proc Natl Acad Sci USA 100:8478-8483.
27. Allan I, Hatch TP, Pearce JH (1985) Influence of cysteine deprivation on chlamydial differentiation from reproductive to infective life-cycle forms. J Gen Microbiol 131:3171-3177.
28. Omsland A, et al. (2009) Host cell-free growth of the Q fever bacterium Coxiella burnetii. Proc Natl Acad Sci USA 106:4430-4434.
29. Crenshaw RW, Fahr MJ, Wichlan DG, Hatch TP (1990) Developmental cycle-specific host-free RNA synthesis in Chlamydia spp. Infect Immun 58:3194-3201.
30. Wang Y, et al. (2011) Development of a transformation system for Chlamydia trachomatis: Restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector. PLoS Pathog 7:e1002258.
31. Kari L, et al. (2011) Generation of targeted Chlamydia trachomatis null mutants. Proc Natl Acad Sci USA 108:7189-7193.
32. Furness G, Graham DM, Reeve P (1960) The titration of trachoma and inclusion blennorrhoea viruses in cell cultures. J Gen Microbiol 23:613-619.
33. Omsland A, et al. (2011) Isolation from animal tissue and genetic transformation of Coxiella burnetii are facilitated by an improved axenic growth medium. Appl Environ Microbiol 77:3720-3725.
34. Moos A, Hackstadt T (1987) Comparative virulence of intra- and interstrain lipopolysaccharide variants of Coxiella burnetii in the guinea pig model. Infect Immun 55:1144-1150.
35. Omsland A, Cockrell DC, Fischer ER, Heinzen RA (2008) Sustained axenic metabolic activity by the obligate intracellular bacterium Coxiella burnetii. J Bacteriol 190:3203-3212.
36. Li M, Villaruz AE, Cha DJ, Sturdevant DE, Otto M (2007) Gram-positive three-component antimicrobial peptide-sensing system. Proc Natl Acad Sci USA 104:9469-9474.