Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 10, 2013, Pages 2876-2879

  Sun, Juan ^a   Li, Ming Hui ^a   Qian, Shao Song ^b   Guo, Feng Jiao ^b   Dang, Xiao Fang ^b   Wang, Xiao Ming ^a   Xue, Ya Rong ^a   Zhu, Hai Liang ^a,b  

^a NANJING UNIVERSITY   (China)

^b SHANDONG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Benzodioxan Oxadiazole Antitumor activity MetAP2 Molecular docking

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; ANTINEOPLASTIC AGENT; FUMAGILLOL CHLOROACETYLCARBAMATE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; UMBILICAL VEIN ENDOTHELIAL CELL;

AMINOPEPTIDASES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; DIOXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLYCOPROTEINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXADIAZOLES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876693154     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.068     Document Type: Article

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