A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles

Archives of Toxicology

Volumn 87, Issue 4, 2013, Pages 721-733

  Hoelting, Lisa ^a   Scheinhardt, Benjamin ^a   Bondarenko, Olesja ^b   Schildknecht, Stefan ^a   Kapitza, Marion ^a   Tanavde, Vivek ^c,d   Tan, Betty ^c   Lee, Qian Yi ^c   Mecking, Stefan ^a   Leist, Marcel ^a   Kadereit, Suzanne ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b NATIONAL INSTITUTE OF CHEMICAL PHYSICS AND BIOPHYSICS   (Estonia)

^c AGENCY FOR SCIENCE   (Singapore)

^d INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

Author keywords

Developmental neurotoxicity (DNT); Human embryonic stem cells; Methylmercury; Neurospheres; Polyethylene nanoparticles

Indexed keywords

COPPER OXIDE; METHYLMERCURY; NANOPARTICLE; NESTIN; NEUROGENIC DIFFERENTIATION FACTOR; NOTCH1 RECEPTOR; POLYETHYLENE; TRANSCRIPTION FACTOR HES 5; TRANSCRIPTION FACTOR MASH1; TRANSCRIPTION FACTOR PAX6;

ACUTE TOXICITY; ARTICLE; ASCL1 GENE; CHRONIC TOXICITY; CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; EMBRYONIC STEM CELL; FOXG1 GENE; GENE EXPRESSION PROFILING; HES5 GENE; HUMAN; HUMAN CELL; NANOTOXICOLOGY; NERVE CELL DIFFERENTIATION; NEUROD1 GENE; NEUROTOXICITY; NOTCH PATHWAY; NOTCH1 GENE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CELLS, IMMOBILIZED; EMBRYOID BODIES; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; METHYLMERCURY COMPOUNDS; NANOPARTICLES; NEURONS; POLYETHYLENE;

MUS;

EID: 84876690267     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0984-2     Document Type: Article

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