Emx1, Emx2 and Pax6 in specification, regionalization and arealization of the cerebral cortex

Cerebral Cortex

Volumn 13, Issue 6, 2003, Pages 641-647

  Muzio, Luca ^a   Mallamaci, Antonello ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b San Raffaele Scientific Institute   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; DIFFERENTIATION; EMBRYO; EMX1 GENE; EMX2 GENE; GANGLION; GENE; GENE CONTROL; GENE MUTATION; HOMEOBOX; MOUSE; MUTANT; NEUROBLAST; NONHUMAN; PAX6 GENE; PRIORITY JOURNAL; PROMOTER REGION; TELENCEPHALON;

ANIMALS; ANIMALS, NEWBORN; CEREBRAL CORTEX; CHORISTOMA; DNA-BINDING PROTEINS; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; MICE; MICE, NEUROLOGIC MUTANTS; NERVOUS SYSTEM MALFORMATIONS; NEURONS; PAIRED BOX TRANSCRIPTION FACTORS; REPRESSOR PROTEINS; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 0037904771     PISSN: 10473211     EISSN: None     Source Type: Journal    
DOI: 10.1093/cercor/13.6.641     Document Type: Article

References (29)

1. Arimatsu Y, Miyamoto M, Nihonmatsu I, Hirata K, Uratani Y, Hatanaka Y, Takiguchi-Hayashi K (1992) Early regional specification for a molecular neuronal phenotype in the rat neocortex. Proc Natl Acad Sci USA 89:8879-8883.
2. Barbe MF, Levitt P (1991) The early commitment of fetal neurons to the limbic cortex. J Neurosci 11:519-533.
3. Bishop KM, Goudreau G, O'Leary DDM (2000) Regulation of area identity in the mammalian neocortex by Emx2 and Pax6. Science 228:344-349.
4. Bishop KM, Rubenstein JLR, O'Leary DDM (2002) Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J Neurosci 22:7627-7638.
5. Briata P, Di Blas E, Gulisano M, Mallamaci A, Iannone R, Boncinelli E, Corte G (1996) EMX1 homeoprotein is expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons. Mech Dev 57:169-180.
6. Corbin JG, Gaiano N, Machold RP, Langston A, Fishell G (2000) The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. Development 127:5007-5020.
7. Crossley PH, Martinez S, Ohkubo Y, Rubenstein JLR (2001) Coordinate expression of FGF8, Otx2, BMP4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles. Neuroscience 108:183-206.
8. Fode C, Ma Q, Casarosa S, Ang SL, Anderson DJ, Guillemot F (2000) A role for neural determination genes in specifying dorso-ventral identity of telencephalic neurons. Genes Dev 14:67-80.
9. Fukuchi-Shimogori T, Grove EA (2001) Neocortex patterning by the secreted signaling molecule FGF8. Science 294:1071-1074.
10. Gitton Y, Cohen-Tannoudji M, Wassef M (1999) Specification of somatosensory area identity in cortical explants. J Neurosci 19:4889-4898.
11. Gulisano M, Broccoli V, Pardini C, Boncinelli E (1996) Emx1 and Emx2 show different patterns of expression during proliferation and differentiation of the developing cerebral cortex in the mouse. Eur J Neurosci 8:1037-1050.
12. Lee SMK, Shuba T, Grove E, McMahon A (2000) A local Wnt-3a signal is required for the development of the mammalian hippocampus. Development 127:457-467.
13. McLaughlin DA, Price J, Mason J (2000) Wnt8b regulates cellular proliferation in the adult dentate gyrus. Soc Neurosci Abstr XXX:228.1.
14. Mallamaci A, Iannone R, Briata P, Pintonello ML, Mercurio S, Boncinelli E, Corte G (1998) EMX2 in the developing mouse brain and in the olfactory area. Mech Dev 77:165-172.
15. -/- mutant mice. Nat Neurosci 3:679-686.
16. Muzio L, DiBenedetto B, Stoykova A, Boncinelli E, Gruss P, Mallamaci A (2002a) Emx2 and Pax6 control regionalisation of the pre-neuronogenic cortical primordium. Cereb Cortex 12:129-139.
17. Sey/Sey double mutant mice. Nat Neurosci 5:737-745.
18. O'Leary DDM, Yasushi Nakagawa Y (2002) Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex. Curr Opin Neurobiol 12:14-25.
19. Ragsdale CW, Grove EA (2001) Patterning the mammalian cerebral cortex. Curr Opin Neurobiol 11:50-58.
20. Shinozaki K, Miyagi T, Yoshida M, Miyata T, Ogawa M, Aizawa S, Suda Y (2002) Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex. Development 129:3479-3492.
21. Simeone A, Gulisano M, Acampora D, Stornaiuolo A, Rambaldi M, Boncinelli E (1992) Two vertebrate genes related to Drosophila empty spiracles gene are expressed in embryonic cerebral cortex. EMBO J 11:2541-2550.
22. Stoykova A, Fritsch R, Walther C, Gruss P (1996) Forebrain patterning defects in Small eye mutant mice. Development 122:3453-3465.
23. Stoykova A, Treichel D, Hallonet M, Gruss P (2000) Pax6 modulates the dorsoventral patterning of the mammalian telencephalon. J Neurosci 20:8042-8050.
24. Theil T, Alvarez-Bolado G, Walter A, Rüther U (1999) Gli3 is required for Emx gene expression during dorsal telencephalon development. Development 126:3561-3571.
25. J. Dev Biol 217:254-265.
26. Toresson H, Potter SS, Campbell K (2000) Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2. Development 127:4361-4371.
27. Walther C, Gruss P (1991) Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113:1435-1449.
28. Yoshida M, Suda Y, Matsuo I, Miyamoto N, Takeda N, Kuratani S, Aizawa S (1997) Emx1 and Emx2 functions in development of dorsal telencephalon. Development 124:101-111.
29. Zhou C, Tsai SY, Tsai MJ (2001) COUP-TFI: an intrinsic factor for early regionalization of the neocortex. Genes Dev 15:2054-2059.