Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin

Biochemical Pharmacology

Volumn 85, Issue 6, 2013, Pages 798-807

  Tao, Feifei ^a   Qian, Cheng ^a   Guo, Wenjie ^a   Luo, Qiong ^a   Xu, Qiang ^a   Sun, Yang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

DSS induced colitis; Icariin; STAT1; STAT3; Th1 Th17

Indexed keywords

CD69 ANTIGEN; CYCLOSPORIN; GAMMA INTERFERON; ICARIIN; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; STAT1 PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DRUG DOSE COMPARISON; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL PROLIFERATION; COLITIS; DNA PRIMERS; DRUGS, CHINESE HERBAL; FEMALE; FLAVONOIDS; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TH1 CELLS; TH17 CELLS;

EID: 84874112880     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.12.002     Document Type: Article

References (32)

1. Kappelman MD, Moore KR, Allen JK, Cook SF. Recent trends in the prevalence of Crohn's disease and ulcerative colitis in a commercially insured US population. Dig Dis Sci 2012; http://dx.doi.org/10.1007/s10620-012-2371-5.
2. M.D. Kappelman, S.L. Rifas-Shiman, K. Kleinman, D. Ollendorf, A. Bousvaros, and R.J. Grand The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States Clin Gastroenterol Hepatol 5 2007 1424 1429 (Pubitemid 350181588)
3. G. Bouma, and W. Strober The immunological and genetic basis of inflammatory bowel disease Nat Rev Immunol 3 2003 521 533 (Pubitemid 37328672)
4. L.A. Zenewicz, A. Antov, and R.A. Flavell CD4 T-cell differentiation and inflammatory bowel disease Trends Mol Med 15 2009 199 207
5. G. Hundorfean, M.F. Neurath, and J. Mudter Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease Inflamm Bowel Dis 18 2012 180 186
6. I. Okayasu, S. Hatakeyama, M. Yamada, T. Ohkusa, Y. Inagaki, and R. Nakaya A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice Gastroenterology 98 1990 694 702 (Pubitemid 20069706)
7. M. Perse, and A. Cerar Dextran sodium sulphate colitis mouse model: traps and tricks J Biomed Biotechnol 2012 2012 718617 10.1155/2012/718617
8. P. Alex, N.C. Zachos, T. Nguyen, L. Gonzales, T.E. Chen, and L.S. Conklin Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis Inflamm Bowel Dis 15 2009 341 352
9. Z.Q. Liu Icariin: a special antioxidant to protect linoleic acid against free-radical-induced peroxidation in micelles J Phys Chem A 110 2006 6372 6378
10. Z.Q. Liu, X.Y. Luo, Y.X. Sun, W. Wu, C.M. Liu, and S.Y. Liu The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis J Pharm Pharmacol 56 2004 1557 1562 (Pubitemid 39601997)
11. F. Zhao, Y.Z. Tang, and Z.Q. Liu Protective effect of icariin on DNA against radical-induced oxidative damage J Pharm Pharmacol 59 2007 1729 1732 (Pubitemid 350221817)
12. Y. Pan, L. Kong, X. Xia, W. Zhang, Z. Xia, and F. Jiang Antidepressant-like effect of icariin and its possible mechanism in mice Pharmacol Biochem Behav 82 2005 686 694 (Pubitemid 43184046)
13. Y. Pan, L.D. Kong, Y.C. Li, X. Xia, H.F. Kung, and F.X. Jiang Icariin from Epimedium brevicornum attenuates chronic mild stress-induced behavioral and neuroendocrinological alterations in male Wistar rats Pharmacol Biochem Behav 87 2007 130 140 (Pubitemid 46855827)
14. J. Wu, J. Du, C. Xu, J. Le, Y. Xu, and B. Liu Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice Pharmacol Biochem Behav 98 2011 273 278
15. M.H. Liu, J.S. Sun, S.W. Tsai, S.Y. Sheu, and M.H. Chen Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation Nutr Res 30 2010 57 65
16. C.Q. Xu, B.J. Liu, J.F. Wu, Y.C. Xu, X.H. Duan, and Y.X. Cao Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway Eur J Pharmacol 642 2010 146 153
17. J. Zhou, J. Wu, X. Chen, N. Fortenbery, E. Eksioglu, and K.N. Kodumudi Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions Int Immunopharmacol 11 2011 890 898
18. X.L. He, W.Q. Zhou, M.G. Bi, and G.H. Du Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence- accelerated mouse prone 8 (SAMP8) mice Brain Res 1334 2010 73 83
19. L. Wang, L. Zhang, Z.B. Chen, J.Y. Wu, X. Zhang, and Y. Xu Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1 Eur J Pharmacol 609 2009 40 44
20. H.R. Zhu, Z.Y. Wang, X.L. Zhu, X.X. Wu, E.G. Li, and Y. Xu Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke Neuropharmacology 59 2010 70 76
21. S.K. Mok, W.F. Chen, W.P. Lai, P.C. Leung, X.L. Wang, and X.S. Yao Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells Br J Pharmacol 159 2010 939 949
22. J. Zhao, S. Ohba, M. Shinkai, U.I. Chung, and T. Nagamune Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner Biochem Biophys Res Commun 369 2008 444 448
23. T.P. Hsieh, S.Y. Sheu, J.S. Sun, M.H. Chen, and M.H. Liu Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression Phytomedicine 17 2010 414 423
24. Y.H. Song, H. Cai, N. Gu, C.F. Qian, S.P. Cao, and Z.M. Zhao Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure J Pharm Pharmacol 63 2011 541 549
25. X.F. Wu, X.X. Wu, W.J. Guo, Q. Luo, Y.H. Gu, and Y. Shen Cerebroside D, a glycoceramide compound, improves experimental colitis in mice with multiple targets against activated T lymphocytes Toxicol Appl Pharmacol 263 2012 296 302
26. X. Wu, W. Guo, L. Wu, Y. Gu, L. Gu, and S. Xu Selective sequestration of STAT1 in the cytoplasm via phosphorylated SHP-2 ameliorates murine experimental colitis J Immunol 189 2012 3497 3507
27. I. Atreya, R. Atreya, and M.F. Neurath NF-kappaB in inflammatory bowel disease J Intern Med 263 2008 591 596
28. W.A. Faubion Jr., E.V. Loftus Jr., W.S. Harmsen, A.R. Zinsmeister, and W.J. Sandborn The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study Gastroenterology 121 2001 255 260 (Pubitemid 32729372)
29. L. Beaugerie, N. Brousse, A.M. Bouvier, J.F. Colombel, M. Lemann, and J. Cosnes Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study Lancet 374 2009 1617 1625
30. A. Kandiel, A.G. Fraser, B.I. Korelitz, C. Brensinger, and J.D. Lewis Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine Gut 54 2005 1121 1125 (Pubitemid 41025906)
31. M. Fort, R. Lesley, N. Davidson, S. Menon, F. Brombacher, and M. Leach IL-4 exacerbates disease in a Th1 cell transfer model of colitis J Immunol 166 2001 2793 2800 (Pubitemid 32173520)
32. Y. Tsukada, T. Nakamura, M. Iimura, B.E. Iizuka, and N. Hayashi Cytokine profile in colonic mucosa of ulcerative colitis correlates with disease activity and response to granulocytapheresis Am J Gastroenterol 97 2002 2820 2828 (Pubitemid 35265434)