Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 10, 2013, Pages 2955-2961

  Mitton Fry, Mark J ^a   Brickner, Steven J ^a   Hamel, Judith C ^a   Brennan, Lori ^a   Casavant, Jeffrey M ^a   Chen, Michael ^a   Chen, Tao ^a   Ding, Xiaoyuan ^a   Driscoll, James ^a   Hardink, Joel ^a   Hoang, Thuy ^a   Hua, Erbing ^a   Huband, Michael D ^a   Maloney, Meghan ^a   Marfat, Anthony ^a   McCurdy, Sandra P ^a   McLeod, Dale ^a   Plotkin, Michael ^a   Reilly, Usa ^a   Robinson, Shaughn ^a   Schafer, John ^a   Shepard, Richard M ^a   Smith, James F ^a   Stone, Gregory G ^a   Subramanyam, Chakrapani ^a   Yoon, Kwansik ^a   Yuan, Wei ^a   Zaniewski, Richard P ^a   Zook, Christopher ^a   more..

^a PFIZER INC   (United States)

Author keywords

Antibacterial DNA gyrase Dual targeting Inhibitor Topoisomerase IV

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL ENZYME; CIPROFLOXACIN; DNA TOPOISOMERASE INHIBITOR; DNA TOPOISOMERASE IV; GYRASE INHIBITOR; POTASSIUM CHANNEL HERG; QUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; LIVER MICROSOME METABOLISM; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; RAT; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; TURNOVER TIME; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-BACTERIAL AGENTS; DNA GYRASE; DNA TOPOISOMERASE IV; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; QUINOLINES; RATS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

BACTERIA (MICROORGANISMS);

EID: 84876673641     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.047     Document Type: Article

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