Exploring Left-Hand-Side substitutions in the benzoxazinone series of 4-amino-piperidine bacterial type IIa topoisomerase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5432-5435

  Geng, Bolin ^a   Comita Prevoir, Janelle ^a   Eyermann, Charles J ^a   Reck, Folkert ^a   Fisher, Stewart ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

4 Amino piperidines; Antibacterials; DNA gyrase; Topoisomerase IV; Type IIa topoisomerases

Indexed keywords

BENZOXAZINONE DERIVATIVE; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL HERG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG POTENCY; ELECTRON; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; IC 50; KLEBSIELLA PNEUMONIAE; MORAXELLA CATARRHALIS; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; SUBSTITUTION REACTION;

BACTERIA; BENZOXAZINES; CRYSTALLOGRAPHY, X-RAY; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS);

EID: 80051932934     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.126     Document Type: Article

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