Selenophene-containing inhibitors of type IIA bacterial topoisomerases

Journal of Medicinal Chemistry

Volumn 54, Issue 9, 2011, Pages 3418-3425

  Wiles, Jason A ^a   Phadke, Avinash S ^a   Bradbury, Barton J ^a   Pucci, Michael J ^a   Thanassi, Jane A ^a   Deshpande, Milind ^a  

^a Achillion Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IIA; DNA TOPOISOMERASE INHIBITOR; POTASSIUM CHANNEL HERG; SELENOPHENE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN;

ANTI-BACTERIAL AGENTS; CELL LINE, TUMOR; DNA GYRASE; DNA TOPOISOMERASE IV; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; ORGANOSELENIUM COMPOUNDS; PIPERIDINES; QUINOLINES; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; TOPOISOMERASE II INHIBITORS;

EID: 79955824986     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2002124     Document Type: Article

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