Discovery and optimization of a series of 2-aryl-4-amino-5-(3′, 4′,5′-trimethoxybenzoyl)thiazoles as novel anticancer agents

Journal of Medicinal Chemistry

Volumn 55, Issue 11, 2012, Pages 5433-5445

  Romagnoli, Romeo ^a   Baraldi, Pier Giovanni ^a   Salvador, Maria Kimatrai ^a   Preti, Delia ^a   Aghazadeh Tabrizi, Mojgan ^a   Brancale, Andrea ^b   Fu, Xian Hua ^c   Li, Jun ^c   Zhang, Su Zhan ^c   Hamel, Ernest ^d   Bortolozzi, Roberta ^e   Porcù, Elena ^e   Basso, Giuseppe ^e   Viola, Giampietro ^e  

^a UNIVERSITY OF FERRARA   (Italy)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

(4 AMINO 2 4 TOLYLTHIAZOL 5YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; 4 AMINO 2 (4 CHLOROPHENYL)THIAZOL 5 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; 4 AMINO 2 (4 FLUOROPHENYL) THIAZOL 5 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; 4 AMINO 2 (THIOPHEN 3 YL)THIAZOL 5 YL)(3,4,5 TRIMETHOXYPHENYL) METHANONE; 4 AMINO 2 PHENYLTHIAZOL 5 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; [4 AMINO 2 (3,4 DIMETHOXYPHENYL)THIAZOL 5 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [4 AMINO 2 (4 ETHOXYPHENYL)THIAZOL 5 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [4 AMINO 2 (4 METHOXYPHENYL)THIAZOL 5 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [4 AMINO 2 (4 TRIFLUOROMETHYLPHENYL)THIAZOL 5 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [4 AMINO 2(4 TERT BUTYLPHENYL) THIAZOL 5 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [4 AMINO2 (4 ETHYLPHENYL)THIAZOL 5 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; CASPASE 3; DOXORUBICIN; PACLITAXEL; PHENYL GROUP; THIAZOLE; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CAPILLARY TUBE; CELL CYCLE; CONTROLLED STUDY; DRUG POTENCY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MITOCHONDRION; MOLECULAR MODEL; MOUSE; NONHUMAN; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; XENOGRAFT;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HUMANS; HYDROXYBENZOIC ACIDS; MICE; MICE, NUDE; MITOCHONDRIA; MODELS, MOLECULAR; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIOPHENES; TRANSPLANTATION, HETEROLOGOUS; TUBULIN MODULATORS;

EID: 84862290410     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300388h     Document Type: Article

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