Preclinical efficacy of melatonin to reduce methotrexate-induced oxidative stress and small intestinal damage in rats

Digestive Diseases and Sciences

Volumn 58, Issue 4, 2013, Pages 959-969

  Kolli, Viswa Kalyan ^a   Abraham, Premila ^a   Isaac, Bina ^a   Kasthuri, N ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Melatonin; Methotrexate; Oxidative stress; Rat; Small intestinal damage

Indexed keywords

CARBONYL DERIVATIVE; MALONALDEHYDE; MELATONIN; METHOTREXATE; MYELOPEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; ENZYME ACTIVITY; INTESTINE; INTESTINE INJURY; MALE; MICROSCOPY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SMALL INTESTINE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTIOXIDANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; INTESTINE, SMALL; MALE; MELATONIN; METHOTREXATE; MUCOSITIS; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 84876664832     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2437-4     Document Type: Article

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