Protective role of lipoic acid on methotrexate induced intestinal damage in rabbit model

Indian Journal of Gastroenterology

Volumn 30, Issue 1, 2011, Pages 38-40

  Somi, Mohammad Hossein ^a   Hajipour, Babak ^b,f   Abad, Ghader Dargahi Abbas ^c   Hemmati, Mohammad Reza ^b   Ghabili, Kamyar ^d   Khodadadi, Ali ^b   Vatankhah, Amir Mansour ^e  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f NONE   (Iran)

Author keywords

Intestine; Methotrexate; Thioctic acid

Indexed keywords

GLUTATHIONE PEROXIDASE; MALONALDEHYDE; METHOTREXATE; SUPEROXIDE DISMUTASE; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; INTESTINE INJURY; INTESTINE PROTECTION; LIPID PEROXIDATION; MALE; NONHUMAN; PROTECTION; RABBIT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; GLUTATHIONE PEROXIDASE; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MALONDIALDEHYDE; METHOTREXATE; MODELS, ANIMAL; OXIDATIVE STRESS; PROTECTIVE AGENTS; RABBITS; RANDOM ALLOCATION; SUPEROXIDE DISMUTASE; THIOCTIC ACID;

EID: 79954618922     PISSN: 02548860     EISSN: 02548860     Source Type: Journal    
DOI: 10.1007/s12664-011-0090-z     Document Type: Article

References (12)

1. Sukhotnik I, Mogilner JG, Karry R, et al. Effect of oral glutamine on enterocyte turnover during methotrexate-induced mucositis in rats. Digestion. 2009; 79: 5-13.
2. Mueller-Koch Y, Vogelsang H, Kopp R, et al. HNPCC-clinical and molecular evidence for a new entity of hereditary colorectal cancer. Gut. 2005; 54: 1676-8.
3. Gao F, Horie T. A synthetic analog of prostaglandin E1 prevents the production of reactive oxygen species in the intestinal mucosa of methotrexate treated rats. Life Sci. 2002; 71: 1091-9.
4. Kremer JM. Toward a better understanding of methotrexate. Arthritis Rheum. 2004; 50: 1370-82.
5. Bilska A, Wlodek L. Lipoic acid-the drug of the future? Pharmacol Rep. 2005; 57: 570-7.
6. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967; 70: 158-69.
7. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95: 351-8.
8. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988; 34: 497-500.
9. Ciralik H, Bulbuloglu E, Cetinkaya A, Kurutas EB, Celik M, Polat A. Effects of N-acetylcysteine on methotrexate-induced small intestinal damage in rats. Mt Sinai J Med. 2006; 73: 1086-92.
10. Cuzzocrea S, Mazzon E, Costantino G, Serraino I, De Sarro A, Caputi AP. Effects of N-acetylcysteine in a rat model of ischemia and reperfusion injury. Cardiovasc Res. 2000; 47: 537-48.
11. Devasagayam TP, Subramanian M, Pradhan DS, Sies H. Prevention of singlet oxygen-induced DNA damage by lipoate. Chem Biol Interact. 1993; 86: 79-92.
12. Li T, Ito K, Sumi S, Fuwa T, Horie T. Protective effect of aged garlic extract (AGE) on the apoptosis of intestinal epithelial cells caused by methotrexate. Cancer Chemother Pharmacol. 2009; 63: 873-80.