Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats

Cancer Chemotherapy and Pharmacology

Volumn 65, Issue 6, 2010, Pages 1117-1123

  Maeda, Tomoko ^a   Miyazono, Yuko ^a   Ito, Kousei ^b   Hamada, Kazuma ^a   Sekine, Shuichi ^a   Horie, Toshiharu ^a  

^a CHIBA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

Chemiluminescence; Glutathione; Intestinal permeability; Methotrexate; N Acetylcysteine; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; METHOTREXATE; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ANTINEOPLASTIC ANTIMETABOLITE; DEXTRAN; DRUG DERIVATIVE; FLUORESCEIN ISOTHIOCYANATE; GLUTATHIONE; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL ASSAY; CELL MEMBRANE PERMEABILITY; CHEMOLUMINESCENCE; CONTROLLED STUDY; IN VITRO STUDY; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; MALE; MOLECULAR WEIGHT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STOMACH PROTECTION; TISSUE HOMOGENATE; ANIMAL; DRUG EFFECT; INTESTINE ABSORPTION; INTESTINE MUCOSA; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; PERMEABILITY; SMALL INTESTINE; TIME; WISTAR RAT;

ACETYLCYSTEINE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BODY WEIGHT; DEXTRANS; FLUORESCEIN-5-ISOTHIOCYANATE; FREE RADICAL SCAVENGERS; GLUTATHIONE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; METHOTREXATE; OXIDATIVE STRESS; PERMEABILITY; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TIME FACTORS;

EID: 77951925209     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-1119-1     Document Type: Article

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