Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: The case of the hEx3 diabody

Protein Engineering, Design and Selection

Volumn 26, Issue 5, 2013, Pages 359-367

  Asano, Ryutaro ^a   Kumagai, Takashi ^a   Nagai, Keisuke ^a   Taki, Shintaro ^a   Shimomura, Ippei ^a   Arai, Kyoko ^a   Ogata, Hiromi ^a   Okada, Mai ^a   Hayasaka, Fumitaka ^a   Sanada, Hideaki ^a   Nakanishi, Takeshi ^a   Karvonen, Teemu ^a   Hayashi, Hiroki ^a   Katayose, Yu ^a   Unno, Michiaki ^a   Kudo, Toshio ^a   Umetsu, Mitsuo ^a   Kumagai, Izumi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Bispecific diabody; Cancer immunotherapy; CD3; Effective domain order; EGFR

Indexed keywords

BISPECIFIC DIABODY; CANCER IMMUNOTHERAPY; CD3; EFFECTIVE DOMAINS; EGFR;

ANTIBODIES; FLOW CYTOMETRY;

CYTOTOXICITY;

ANTINEOPLASTIC AGENT; BISPECIFIC ANTIBODY; CD3 ANTIGEN; DIMER; EPIDERMAL GROWTH FACTOR RECEPTOR; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CROSS LINKING; CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIGENS, CD3; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MICE; NEOPLASMS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR;

MUS;

EID: 84876564677     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzt009     Document Type: Article

References (35)

1. Asano, R., Sone, Y., Makabe, K., Tsumoto, K., Hayashi, H., Katayose, Y., Unno, M., Kudo, T. and Kumagai, I. (2006) Clin. Cancer Res., 12, 4036-4042.
2. Asano, R., Watanabe, Y., Kawaguchi, H., et al. (2007) J. Biol. Chem., 282, 27659-27665.
3. Asano, R., Kawaguchi, H., Watanabe, Y., et al. (2008) J. Immunother., 31, 752-761.
4. Asano, R., Ikoma, K., Sone, Y., et al. (2010) J. Biol. Chem., 285, 20844-20849.
5. Asano, R., Ikoma, K., Shimomura, I., Taki, S., Nakanishi, T., Umetsu, M. and Kumagai, I. (2011) J. Biol. Chem., 286, 1812-1818.
6. Bargou, R., Leo, E., Zugmaier, G., et al. (2008) Science, 321, 974-977.
7. Buhler, P., Wolf, P., Gierschner, D., et al. (2008) Cancer Immunol. Immunother., 57, 43-52.
8. Cao, Y. and Lam, L. (2003) Adv. Drug Deliv. Rev., 55, 171-197.
9. Carter, P. (2001) J. Immunol. Methods, 248, 7-15.
10. De Jonge, J., Brissinck, J., Heirman, C., Demanet, C., Leo, O., Moser, M. and Thielemans, K. (1995) Mol. Immunol., 32, 1405-1412.
11. Holliger, P. and Winter, G. (1997) Cancer Immunol. Immunother., 45, 128-130.
12. Karlsson, R., Michaelsson, A. and Mattsson, L. (1991) J. Immunol. Methods, 145, 229-240.
13. Kipriyanov, S.M., Moldenhauer, G., Braunagel, M., Reusch, U., Cochlovius, B., Le Gall, F., Kouprianova, O.A., Von der Lieth, C.W. and Little, M. (2003) J. Mol. Biol., 330, 99-111.
14. Kontermann, R.E. (2005) Acta Pharmacol. Sin., 26, 1-9.
15. Korn, T., Nettelbeck, D.M., Volkel, T., Muller, R. and Kontermann, R.E. (2004) J. Gene Med., 6, 642-651.
16. Kriangkum, J., Xu, B., Nagata, L.P., Fulton, R.E. and Suresh, M.R. (2001) Biomol. Eng., 18, 31-40.
17. Kufer, P., Lutterbuse, R. and Baeuerle, P.A. (2004) Trends Biotechnol., 22, 238-244.
18. Loffler, A., Kufer, P., Lutterbuse, R., Zettl, F., Daniel, P.T., Schwenkenbecher, J.M., Riethmuller, G., Dorken, B. and Bargou, R.C. (2000) Blood, 95, 2098-2103.
19. Lu, D., Jimenez, X., Witte, L. and Zhu, Z. (2004) Biochem. Biophys. Res. Commun., 318, 507-513.
20. Makabe, K., Nakanishi, T., Tsumoto, K., Tanaka, Y., Kondo, H., Umetsu, M., Sone, Y., Asano, R. and Kumagai, I. (2008) J. Biol. Chem., 283, 1156-1166.
21. Mallender, W.D. and Voss, E.W., Jr. (1994) J. Biol. Chem., 269, 199-206.
22. Marvin, J.S. and Zhu, Z. (2005) Acta Pharmacol. Sin., 26, 649-658.
23. McCall, A.M., Shahied, L., Amoroso, A.R., et al. (2001) J. Immunol., 166, 6112-6117.
24. Molhoj, M., Crommer, S., Brischwein, K., Rau, D., Sriskandarajah, M., Hoffmann, P., Kufer, P., Hofmeister, R. and Baeuerle, P.A. (2007) Mol. Immunol., 44, 1935-1943.
25. Raso, V. and Griffin, T. (1981) Cancer Res., 41, 2073-2078.
26. Robinson, M.K., Doss, M., Shaller, C., Narayanan, D., Marks, J.D., Adler, L.P., Gonzalez Trotter, D.E. and Adams, G.P. (2005) Cancer Res., 65, 1471-1478.
27. Saijyo, S., Kudo, T., Suzuki, M., Katayose, Y., Shinoda, M., Muto, T., Fukuhara, K., Suzuki, T. and Matsuno, S. (1995) Tohoku J Exp Med, 177, 61-71.
28. Segal, D.M., Weiner, G.J. and Weiner, L.M. (1999) Curr. Opin. Immunol., 11, 558-562.
29. Shahied, L.S., Tang, Y., Alpaugh, R.K., Somer, R., Greenspon, D. and Weiner, L.M. (2004) J. Biol. Chem., 279, 53907-53914.
30. Stork, R., Campigna, E., Robert, B., Muller, D. and Kontermann, R.E. (2009) J. Biol. Chem., 284, 25612-25619.
31. Sundaresan, G., Yazaki, P.J., Shively, J.E., et al. (2003) J. Nucl. Med., 44, 1962-1969.
32. Suresh, M.R., Cuello, A.C. and Milstein, C. (1986) Methods Enzymol., 121, 210-228.
33. Takemura, S., Asano, R., Tsumoto, K., et al. (2000) FEBS Lett., 476, 266-271.
34. van Spriel, A.B., van Ojik, H.H. and van De Winkel, J.G. (2000) Immunol. Today, 21, 391-397.
35. Wiseman, T., Williston, S., Brandts, J.F. and Lin, L.N. (1989) Anal. Biochem., 179, 131-137.