Cytotoxic enhancement of a bispecific diabody by format conversion to tandem single-chain variable fragment (taFv): The case of the hEx3 diabody

Journal of Biological Chemistry

Volumn 286, Issue 3, 2011, Pages 1812-1818

  Asano, Ryutaro ^a   Ikoma, Keiko ^a   Shimomura, Ippei ^a   Taki, Shintaro ^a   Nakanishi, Takeshi ^a   Umetsu, Mitsuo ^a   Kumagai, Izumi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; BINDING KINETICS; CANCER IMMUNOTHERAPY; CROSS-LINKING ABILITY; CYTOTOXIC; CYTOTOXICITY ASSAYS; DIABODY; EPIDERMAL GROWTH FACTOR RECEPTORS; FORMAT CONVERSION; GROWTH INHIBITION; IMMUNE CELLS; STERIC HINDRANCES; SURFACE PLASMON RESONANCE SPECTROSCOPY; TARGET CELLS; THERMO DYNAMIC ANALYSIS; VARIABLE FRAGMENT;

BINDING ENERGY; CYTOTOXICITY; FLOW CYTOMETRY; PLANTS (BOTANY); PLASMONS; SELF ASSEMBLY; SURFACE PLASMON RESONANCE; THERMOANALYSIS;

ANTIBODIES;

ANTIGEN; BISPECIFIC ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANTIBODY STRUCTURE; ARTICLE; BINDING AFFINITY; BIOTRANSFORMATION; CELL GROWTH; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; CYTOTOXICITY; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; SURFACE PLASMON RESONANCE; TARGET CELL; THERMODYNAMICS;

ANTIBODIES, BISPECIFIC; ANTIGENS, CD3; ANTINEOPLASTIC AGENTS; CYTOTOXINS; HUMANS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SINGLE-CHAIN ANTIBODIES; T-LYMPHOCYTES;

EID: 78751482760     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.172957     Document Type: Article

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