Secretory defect and cytotoxicity : the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP)

Journal of Biological Chemistry

Volumn 288, Issue 16, 2013, Pages 11395-11406

  Li, Songhua ^a   Yang, Zhihui ^a,d   Hu, Jane ^c   Gordon, William C ^a   Bazan, Nicolas G ^a   Haas, Arthur L ^b   Bok, Dean ^c   Jin, Minghao ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JULES STEIN EYE INSTITUTE   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC; DISULFIDE BONDS; ENDOPLASMIC RETICULUM STRESS; INTERPHOTORECEPTOR RETINOID-BINDING PROTEINS; MISFOLDING; NORMAL FUNCTION; RETINAL DEGENERATIONS; RETINITIS PIGMENTOSA;

CELL MEMBRANES; COVALENT BONDS; GLYCOPROTEINS;

CYTOTOXICITY;

ACTIVATING TRANSCRIPTION FACTOR 4; ALANINE; CCAAT ENHANCER BINDING PROTEIN; CHAPERONE; CYSTEINE; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; MESSENGER RNA; MUTANT PROTEIN; PROTEIN DISULFIDE ISOMERASE; PROTEIN DISULFIDE ISOMERASE A2; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; DISULFIDE BOND; ENDOPLASMIC RETICULUM STRESS; GAIN OF FUNCTION MUTATION; GENE MUTATION; GOLGI COMPLEX; LOSS OF FUNCTION MUTATION; LOW TEMPERATURE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN TRANSPORT; RETINITIS PIGMENTOSA; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SUBSTITUTION; ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; CELL NUCLEUS; ENDOPLASMIC RETICULUM; EYE PROTEINS; GOLGI APPARATUS; HEAT-SHOCK PROTEINS; HUMANS; MICE; MUTATION, MISSENSE; PROTEIN DISULFIDE-ISOMERASES; PROTEIN FOLDING; RETINITIS PIGMENTOSA; RETINOL-BINDING PROTEINS; UNFOLDED PROTEIN RESPONSE;

EID: 84876559673     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.418251     Document Type: Article

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