The Focal Adhesion: A Regulated Component of Aortic Stiffness

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Saphirstein, Robert J ^a,b   Gao, Yuan Z ^a,b   Jensen, Mikkel H ^c,d   Gallant, Cynthia M ^b   Vetterkind, Susanne ^b   Moore, Jeffrey R ^d   Morgan, Kathleen G ^b  

^a Boston University   (United States)

^b BOSTON UNIVERSITY   (United States)

^c Boston University   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE INHIBITOR; LYSOPHOSPHATIDIC ACID; MYOSIN; PAXILLIN; PHENYLEPHRINE; PHOSPHOPROTEIN PHOSPHATASE 2; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; LYSOPHOSPHOLIPID; MYOSIN LIGHT CHAIN KINASE; PYRIMIDINE DERIVATIVE;

ACTIN MYOSIN INTERACTION; ANIMAL CELL; ANIMAL TISSUE; AORTA WALL; ARTERIAL STIFFNESS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSKELETON; FOCAL ADHESION; FOLLOW UP; NONHUMAN; OSCILLATORY POTENTIAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; STARVATION; VASCULAR RING; VASCULAR SMOOTH MUSCLE; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTA; DRUG EFFECTS; EXTRACELLULAR MATRIX; IN VITRO STUDY; METABOLISM; MUSCLE CONTRACTION; PHOSPHORYLATION;

ANIMALS; AORTA; EXTRACELLULAR MATRIX; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FOCAL ADHESIONS; IN VITRO TECHNIQUES; LYSOPHOSPHOLIPIDS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; MYOSIN-LIGHT-CHAIN KINASE; PHOSPHORYLATION; PYRIMIDINES; RATS; SRC-FAMILY KINASES; VASCULAR STIFFNESS;

EID: 84876557790     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062461     Document Type: Article

References (57)

1. Mitchell GF, Hwang SJ, Vasan RS, Larson MG, Pencina MJ, et al. (2010) Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation 121: 505-511.
2. Kaess BM, Rong J, Larson MG, Hamburg NM, Vita JA, et al. (2012) Aortic stiffness, blood pressure progression, and incident hypertension. JAMA 308: 875-881.
3. Greenwald SE, (2007) Ageing of the conduit arteries. J Pathol 211: 157-172.
4. Brozovich FV, Morgan KG, (1989) Stimulus-specific changes in mechanical properties of vascular smooth muscle. Am J Physiol 257: H1573-1580.
5. Qiu H, Zhu Y, Sun Z, Trzeciakowski JP, Gansner M, et al. (2010) Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging. Circ Res 107: 615-619.
6. Kim HR, Gallant C, Leavis PC, Gunst SJ, Morgan KG, (2008) Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent. Am J Physiol Cell Physiol 295: C768-778.
7. Small JV, (1985) Geometry of actin-membrane attachments in the smooth muscle cell: the localisations of vinculin and alpha-actinin. EMBO J 4: 45-49.
8. Vetterkind S, Saphirstein RJ, Morgan KG, (2011) Stimulus-specific activation and actin dependency of distinct, spatially separated ERK1/2 fractions in A7r5 smooth muscle cells. PLoS One 7: e30409.
9. Kimes BW, Brandt BL, (1976) Characterization of two putative smooth muscle cell lines from rat thoracic aorta. Exp Cell Res 98: 349-366.
10. Firulli AB, Han D, Kelly-Roloff L, Koteliansky VE, Schwartz SM, et al. (1998) A comparative molecular analysis of four rat smooth muscle cell lines. In Vitro Cell Dev Biol Anim 34: 217-226.
11. Gimona M, Kaverina I, Resch GP, Vignal E, Burgstaller G, (2003) Calponin repeats regulate actin filament stability and formation of podosomes in smooth muscle cells. Mol Biol Cell 14: 2482-2491.
12. Martinez-Lemus LA, Wu X, Wilson E, Hill MA, Davis GE, et al. (2003) Integrins as unique receptors for vascular control. J Vasc Res 40: 211-233.
13. Mogford JE, Davis GE, Meininger GA, (1997) RGDN peptide interaction with endothelial alpha5beta1 integrin causes sustained endothelin-dependent vasoconstriction of rat skeletal muscle arterioles. J Clin Invest 100: 1647-1653.
14. Pierschbacher MD, Ruoslahti E, (1987) Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion. J Biol Chem 262: 17294-17298.
15. Kollmannsberger P, Fabry B, (2007) High-force magnetic tweezers with force feedback for biological applications. Rev Sci Instrum 78: 114301.
16. Kasas S, Wang X, Hirling H, Marsault R, Huni B, et al. (2005) Superficial and deep changes of cellular mechanical properties following cytoskeleton disassembly. Cell Motil Cytoskeleton 62: 124-132.
17. Matthews BD, Overby DR, Alenghat FJ, Karavitis J, Numaguchi Y, et al. (2004) Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochem Biophys Res Commun 313: 758-764.
18. Oberleithner H, Callies C, Kusche-Vihrog K, Schillers H, Shahin V, et al. (2009) Potassium softens vascular endothelium and increases nitric oxide release. Proc Natl Acad Sci U S A 106: 2829-2834.
19. Rotsch C, Jacobson K, Radmacher M, (1999) Dimensional and mechanical dynamics of active and stable edges in motile fibroblasts investigated by using atomic force microscopy. Proc Natl Acad Sci U S A 96: 921-926.
20. Matthews BD, Overby DR, Mannix R, Ingber DE, (2006) Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci 119: 508-518.
21. Meijering E, Dzyubachyk O, Smal I, (2012) Methods for cell and particle tracking. Methods Enzymol 504: 183-200.
22. Min J, Reznichenko M, Poythress RH, Gallant CM, Vetterkind S, et al. (2012) Src modulates contractile vascular smooth muscle function via regulation of focal adhesions. J Cell Physiol.
23. Cai Y, Sheetz MP, (2009) Force propagation across cells: mechanical coherence of dynamic cytoskeletons. Curr Opin Cell Biol 21: 47-50.
24. Bulter WE, Peterson JW, Zervas NT, Morgan KG (1996) Intracellular calcium, myosin light chain phosphorylation, and contractile force in experimental cerebral vasospasm. Neurosurgery 38: 781-787; discussion 787-788.
25. Marganski WA, Gangopadhyay SS, Je HD, Gallant C, Morgan KG, (2005) Targeting of a novel Ca+2/calmodulin-dependent protein kinase II is essential for extracellular signal-regulated kinase-mediated signaling in differentiated smooth muscle cells. Circ Res 97: 541-549.
26. Driska SP, Aksoy MO, Murphy RA, (1981) Myosin light chain phosphorylation associated with contraction in arterial smooth muscle. Am J Physiol 240: C222-233.
27. Bárány M (1996) Biochemistry of smooth muscle contraction. San Diego: Academic Press.
28. Wagenseil JE, Mecham RP, (2009) Vascular extracellular matrix and arterial mechanics. Physiol Rev 89: 957-989.
29. Rhee AY, Brozovich FV, (2000) The smooth muscle cross-bridge cycle studied using sinusoidal length perturbations. Biophys J 79: 1511-1523.
30. Jiang MJ, Morgan KG, (1989) Agonist-specific myosin phosphorylation and intracellular calcium during isometric contractions of arterial smooth muscle. Pflugers Arch 413: 637-643.
31. Chrzanowska-Wodnicka M, Burridge K, (1996) Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol 133: 1403-1415.
32. Jones LG, Ella KM, Bradshaw CD, Gause KC, Dey M, et al. (1994) Activations of mitogen-activated protein kinases and phospholipase D in A7r5 vascular smooth muscle cells. J Biol Chem 269: 23790-23799.
33. Fincham VJ, Frame MC, (1998) The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J 17: 81-92.
34. Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, et al. (2004) FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol 6: 154-161.
35. Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, et al. (2007) The selectivity of protein kinase inhibitors: a further update. Biochem J 408: 297-315.
36. Sun Z, Martinez-Lemus LA, Hill MA, Meininger GA, (2008) Extracellular matrix-specific focal adhesions in vascular smooth muscle produce mechanically active adhesion sites. Am J Physiol Cell Physiol 295: C268-278.
37. Bershadsky AD, Balaban NQ, Geiger B, (2003) Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol 19: 677-695.
38. Mierke CT, (2009) The Role of Vinculin in the Regulation of the Mechanical Properties of Cells. Cell Biochemistry and Biophysics 53: 115-126.
39. Horowitz A, Menice CB, Laporte R, Morgan KG, (1996) Mechanisms of smooth muscle contraction. Physiol Rev 76: 967-1003.
40. Huveneers S, Danen EH, (2009) Adhesion signaling- crosstalk between integrins, Src and Rho. J Cell Sci 122: 1059-1069.
41. Somlyo AP, Somlyo AV, (2003) Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83: 1325-1358.
42. Shin HM, Je HD, Gallant C, Tao TC, Hartshorne DJ, et al. (2002) Differential association and localization of myosin phosphatase subunits during agonist-induced signal transduction in smooth muscle. Circ Res 90: 546-553.
43. Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, et al. (2008) A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. Journal of Medicinal Chemistry 51: 7405-7416.
44. Mitra SK, Hanson DA, Schlaepfer DD, (2005) Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 6: 56-68.
45. Khalil RA, Menice CB, Wang CL, Morgan KG, (1995) Phosphotyrosine-dependent targeting of mitogen-activated protein kinase in differentiated contractile vascular cells. Circ Res 76: 1101-1108.
46. Dessy C, Kim I, Sougnez CL, Laporte R, Morgan KG, (1998) A role for MAP kinase in differentiated smooth muscle contraction evoked by alpha-adrenoceptor stimulation. Am J Physiol 275: C1081-1086.
47. Deng L, Trepat X, Butler JP, Millet E, Morgan KG, et al. (2006) Fast and slow dynamics of the cytoskeleton. Nat Mater 5: 636-640.
48. Wang Y, Botvinick EL, Zhao Y, Berns MW, Usami S, et al. (2005) Visualizing the mechanical activation of Src. Nature 434: 1040-1045.
49. Geiger B, Bershadsky A, Pankov R, Yamada KM, (2001) Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat Rev Mol Cell Biol 2: 793-805.
50. Choquet D, Felsenfeld DP, Sheetz MP, (1997) Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell 88: 39-48.
51. Felsenfeld DP, Schwartzberg PL, Venegas A, Tse R, Sheetz MP, (1999) Selective regulation of integrin-cytoskeleton interactions by the tyrosine kinase Src. Nat Cell Biol 1: 200-206.
52. North AJ, Gimona M, Lando Z, Small JV, (1994) Actin isoform compartments in chicken gizzard smooth muscle cells. J Cell Sci 107 (Pt 3): 445-455.
53. Vetterkind S, Lee E, Sundberg E, Poythress RH, Tao TC, et al. (2010) Par-4: a new activator of myosin phosphatase. Mol Biol Cell 21: 1214-1224.
54. Balaban NQ, Schwarz US, Riveline D, Goichberg P, Tzur G, et al. (2001) Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Nat Cell Biol 3: 466-472.
55. Zhang W, Gunst SJ, (2008) Interactions of airway smooth muscle cells with their tissue matrix: implications for contraction. Proc Am Thorac Soc 5: 32-39.
56. Li Y, Gallant C, Malek S, Morgan KG, (2007) Focal adhesion signaling is required for myometrial ERK activation and contractile phenotype switch before labor. Journal of Cellular Biochemistry 100: 129-140.
57. Hu K, Ji L, Applegate KT, Danuser G, Waterman-Storer CM, (2007) Differential transmission of actin motion within focal adhesions. Science 315: 111-115.