Src modulates contractile vascular smooth muscle function via regulation of focal adhesions

Journal of Cellular Physiology

Volumn 227, Issue 11, 2012, Pages 3585-3592

  Min, Jianghong ^a   Reznichenko, Maya ^a   Poythress, Ransom H ^a   Gallant, Cynthia M ^a   Vetterkind, Susanne ^a   Li, Yunping ^a,b   Morgan, Kathleen G ^a  

^a BOSTON UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PAXILLIN; PROTEIN TYROSINE KINASE;

ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FOCAL ADHESION; MUSCLE CONTRACTILITY; MUSCLE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; FERRETS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FOCAL ADHESIONS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; ORGAN CULTURE TECHNIQUES; PHENYLEPHRINE; PHOSPHORYLATION; PHOSPHOTYROSINE; PYRIMIDINES; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84864096689     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24062     Document Type: Article

References (37)

1. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. 2003. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci USA 100: 13298- 13302.
2. Berk BC, Corson MA. 1997. Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases. Circ Res 80: 607- 616.
3. Bishop JM, Baker B, Fujita D, McCombe P, Sheiness D, Smith K, Spector DH, Stehelin D, Varmus HE. 1978. Genesis of a virus-transforming gene. Natl Cancer Inst Monogr 48: 219- 223.
4. Burridge K, Chrzanowska-Wodnicka M. 1996. Focal adhesions, contractility, and signaling. Annu Rev Cell Dev Biol 12: 463- 518.
5. Clark EA, Brugge JS. 1993. Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets. Mol Cell Biol 13: 1863- 1871.
6. Dessy C, Kim I, Sougnez CL, Laporte R, Morgan KG. 1998. A role for MAP kinase in differentiated smooth muscle contraction evoked by alpha-adrenoceptor stimulation. Am J Physiol Cell Physiol 275: C1081- C1086.
7. Fincham VJ, James M, Frame MC, Winder SJ. 2000. Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src. Embo J 19: 2911- 2923.
8. Flavahan NA, Bailey SR, Flavahan WA, Mitra S, Flavahan S. 2005. Imaging remodeling of the actin cytoskeleton in vascular smooth muscle cells after mechanosensitive arteriolar constriction. Am J Physiol Heart Circ Physiol 288: H660- 669.
9. Fonseca PM, Shin NY, Brabek J, Ryzhova L, Wu J, Hanks SK. 2004. Regulation and localization of CAS substrate domain tyrosine phosphorylation. Cell Signal 16: 621- 629.
10. Geiger B, Bershadsky A, Pankov R, Yamada KM. 2001. Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat Rev Mol Cell Biol 2: 793- 805.
11. Huang Y, Zhang W, Gunst SJ. 2011. Activation of vinculin induced by cholinergic stimulation regulates contraction of tracheal smooth muscle tissue. J Biol Chem 286: 3630- 3644.
12. Ishida T, Ishida M, Suero J, Takahashi M, Berk BC. 1999. Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. J Clin Invest 103: 789- 797.
13. Khalil RA, Menice CB, Wang C-L, Morgan KG. 1995. Phosphotyrosine-dependent targeting of mitogen-activated protein kinase in differentiated contractile vascular cells. Circ Res 76: 1101- 1108.
14. Khalil RA, Morgan KG. 1993. PKC-mediated redistribution of mitogen-activated protein kinase during smooth muscle activation. Am J Physiol 265: C406- C411.
15. Kim HR, Gallant C, Leavis PC, Gunst SJ, Morgan KG. 2008. Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform-dependent and stimulus-dependent. Am J Physiol Cell Physiol 295: C768- C778.
16. Kim HR, Graceffa P, Ferron F, Gallant C, Boczkowska M, Dominguez R, Morgan KG. 2010. Actin polymerization in differentiated vascular smooth muscle cells requires vasodilator-stimulated phosphoprotein. Am J Physiol Cell Physiol 298: C559- C571.
17. Kim I, Je HD, Gallant C, Zhan Q, Riper DV, Badwey JA, Singer HA, Morgan KG. 2000. Ca2+-calmodulin-dependent protein kinase II-dependent activation of contractility in ferret aorta. J Physiol 526: 367- 374.
18. Kim LC, Song L, Haura EB. 2009. Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol 6: 587- 595.
19. Knock GA, Snetkov VA, Shaifta Y, Drndarski S, Ward JP, Aaronson PI. 2008. Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery. Cardiovasc Res 80: 453- 462.
20. Li Y, Reznichenko M, Tribe RM, Hess PE, Taggart M, Kim H, DeGnore JP, Gangopadhyay S, Morgan KG. 2009. Stretch activates human myometrium via ERK, caldesmon and focal adhesion signaling. PLoS One 4: e7489.
21. Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ. 2007. Structural basis for the autoinhibition of focal adhesion kinase. Cell 129: 1177- 1187.
22. Marganski WA, Gangopadhyay SS, Je H-D, Gallant C, Morgan KG. 2005. Targeting of a novel Ca+2/calmodulin-dependent Protein kinase II is essential for extracellular signal-regulated kinase-mediated signaling in differentiated smooth muscle cells. Circ Res 97: 541- 549.
23. Mitchell GF. 2009. Arterial stiffness and wave reflection: Biomarkers of cardiovascular risk. Artery Res 3: 56- 64.
24. Mitra SK, Mikolon D, Molina JE, Hsia DA, Hanson DA, Chi A, Lim ST, Bernard-Trifilo JA, Ilic D, Stupack DG, Cheresh DA, Schlaepfer DD. 2006. Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors. Oncogene 25: 5969- 5984.
25. Mitra SK, Schlaepfer DD. 2006. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18: 516- 523.
26. Ohanian V, Gatfield K, Ohanian J. 2005. Role of the actin cytoskeleton in G-protein-coupled receptor activation of PYK2 and paxillin in vascular smooth muscle. Hypertension 46: 93- 99.
27. Qiu H, Zhu Y, Sun Z, Trzeciakowski JP, Gansner M, Depre C, Resuello RR, Natividad FF, Hunter WC, Genin GM, Elson EL, Vatner DE, Meininger GA, Vatner SF. 2010. Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging. Circ Res 107: 615- 619.
28. Salazar EP, Rozengurt E. 2001. Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397. J Biol Chem 276: 17788- 17795.
29. Seong J, Lu S, Ouyang M, Huang H, Zhang J, Frame MC, Wang Y. 2009. Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chem Biol 16: 48- 57.
30. Sugimura K, Fukumoto Y, Nawata J, Wang H, Onoue N, Tada T, Shirato K, Shimokawa H. 2010. Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats: implication for the pathogenesis of hypertensive vascular disease. Tohoku J Exp Med 222: 201- 210.
31. Sun Z, Martinez-Lemus LA, Hill MA, Meininger GA. 2008. Extracellular matrix-specific focal adhesions in vascular smooth muscle produce mechanically active adhesion sites. Am J Physiol Cell Physiol 295: C268- 278.
32. Tang DD, Wu MF, Opazo Saez AM, Gunst SJ. 2002. The focal adhesion protein paxillin regulates contraction in canine tracheal smooth muscle. J Physiol 542: 501- 513.
33. Taniyama Y, Weber DS, Rocic P, Hilenski L, Akers ML, Park J, Hemmings BA, Alexander RW, Griendling KK. 2003. Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. Mol Cell Biol 23: 8019- 8029.
34. Thomas SM, Brugge JS. 1997. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13: 513- 609.
35. Ward DT, Alder AC, Ohanian J, Ohanian V. 2002. Noradrenaline-induced paxillin phosphorylation, ERK activation and MEK-regulated contraction in intact rat mesenteric arteries. J Vasc Res 39: 1- 11.
36. Wu X, Yang Y, Gui P, Sohma Y, Meininger GA, Davis GE, Braun AP, Davis MJ. 2008. Potentiation of large conductance, Ca2+-activated K+ (BK) channels by alpha5beta1 integrin activation in arteriolar smooth muscle. J Physiol 586: 1699- 1713.
37. Yamboliev IA, Chen J, Gerthoffer WT. 2001. PI 3-kinases and Src kinases regulate spreading and migration of cultured VSMCs. Am J Physiol Cell Physiol 281: C709- 718.