Arrestin scaffolds NHERF1 to the P2Y12 receptor to regulate receptor internalization

Journal of Biological Chemistry

Volumn 287, Issue 29, 2012, Pages 24505-24515

  Nisar, Shaista P ^a   Cunningham, Margaret ^a   Saxena, Kunal ^a   Pope, Robert J ^a   Kelly, Eamonn ^a   Mundell, Stuart J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARRESTINS; G-PROTEIN COUPLED RECEPTORS; IN-VITRO; PDZ BINDING MOTIF; RECEPTOR STIMULATION; SCAFFOLDING PROTEINS;

PLATELETS;

PROTEINS;

G PROTEIN COUPLED RECEPTOR; MEMBRANE PROTEIN; NHERF1 PROTEIN; NHERF2 PROTEIN; PURINERGIC P2Y12 RECEPTOR; RETINA S ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; PDZ BINDING MOTIF; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION;

ARRESTIN; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; ENDOCYTOSIS; HUMANS; IMMUNOPRECIPITATION; PDZ DOMAINS; PHOSPHOPROTEINS; PROTEIN BINDING; RECEPTORS, PURINERGIC P2Y12; RNA, SMALL INTERFERING; SODIUM-HYDROGEN ANTIPORTER;

EID: 84863799509     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.347104     Document Type: Article

References (39)

1. Wolfe, B. L., and Trejo, J. (2007) Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis. Traffic 8, 462-470 (Pubitemid 46638559)
2. Hanyaloglu, A. C., and von Zastrow, M. (2008) Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu. Rev. Pharmacol. Toxicol. 48, 537-568 (Pubitemid 351738163)
3. Marchese, A., Paing, M. M., Temple, B. R., and Trejo, J. (2008) G proteincoupled receptor sorting to endosomes and lysosomes. Annu. Rev. Pharmacol. Toxicol. 48, 601-629 (Pubitemid 351738165)
4. Romero, G., von Zastrow, M., and Friedman, P. A. (2011) Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs. Means, motif, and opportunity. Adv. Pharmacol. 62, 279-314
5. 2-adrenergic receptor. Nature 401, 286-290
6. Fam, S. R., Paquet, M., Castleberry, A. M., Oller, H., Lee, C. J., Traynelis, S. F., Smith, Y., Yun, C. C., and Hall, R. A. (2005) P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2. Proc. Natl. Acad. Sci. U.S.A. 102, 8042-8047 (Pubitemid 40781059)
7. Wang, B., Bisello, A., Yang, Y., Romero, G. G., and Friedman, P. A. (2007) NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling. J. Biol. Chem. 282, 36214-36222
8. Lauffer, B. E., Melero, C., Temkin, P., Lei, C., Hong, W., Kortemme, T., and von Zastrow, M. (2010) SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. J. Cell Biol. 190, 565-574
9. Nisar, S., Daly, M. E., Federici, A. B., Artoni, A., Mumford, A. D., Watson, S. P., and Mundell, S. J. (2011) An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets. Blood 118, 5641-5651
10. Mundell, S. J., Barton, J. F., Mayo-Martin, M. B., Hardy, A. R., and Poole, A. W. (2008) Rapid resensitization of purinergic receptor function in human platelets. J. Thromb. Haemost. 6, 1393-1404 (Pubitemid 352022551)
11. Mundell, S. J., Luo, J., Benovic, J. L., Conley, P. B., and Poole, A. W. (2006) Distinct clathrin-coated pits sort different G protein-coupled receptor cargo. Traffic 7, 1420-1431 (Pubitemid 44364179)
12. Mundell, S. J., Jones, M. L., Hardy, A. R., Barton, J. F., Beaucourt, S. M., Conley, P. B., and Poole, A. W. (2006) Distinct roles for protein kinase C isoforms in regulating platelet purinergic receptor function. Mol. Pharmacol. 70, 1132-1142 (Pubitemid 44268470)
13. Pula, G., Crosby, D., Baker, J., and Poole, A. W. (2005) Functional interaction of protein kinase Cα with the tyrosine kinases Syk and Src in human platelets. J. Biol. Chem. 280, 7194-7205 (Pubitemid 40341277)
14. Hardy, A. R., Conley, P. B., Luo, J., Benovic, J. L., Poole, A. W., and Mundell, S. J. (2005) P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms. Blood 105, 3552-3560 (Pubitemid 40628200)
15. + exchanger regulatory factor family of PDZ proteins. Proc. Natl. Acad. Sci. U.S.A. 95, 8496-8501
16. + exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human κ-opioid receptor by enhancing its recycling rate. J. Biol. Chem. 277, 27545-27552
17. Wheeler, D., and Sneddon, W. B. (2006) Mutation of phenylalanine-34 of parathyroid hormone disrupts NHERF1 regulation of PTH type I receptor signaling. Endocrine 30, 343-352 (Pubitemid 47010971)
18. Fouassier, L., Nichols, M. T., Gidey, E., McWilliams, R. R., Robin, H., Finnigan, C., Howell, K. E., Housset, C., and Doctor, R. B. (2005) Protein kinase C regulates the phosphorylation and oligomerization of ERM binding phosphoprotein 50. Exp. Cell Res. 306, 264-273 (Pubitemid 40692789)
19. + exchanger regulatory factor via a PDZ domain-mediated interaction. J. Biol. Chem. 274, 24328-24334
20. q signaling. Regulation by EBP50. J. Biol. Chem. 278, 17827-17837
21. Mundell, S. J., Matharu, A. L., Nisar, S., Palmer, T. M., Benovic, J. L., and Kelly, E. (2010) Deletion of the distal COOH terminus of the A2B adenosine receptor switches internalization to an arrestin- and clathrin-independent pathway and inhibits recycling. Br. J. Pharmacol. 159, 518-533
22. + exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells. Mol Endocrinol 22, 1163-1170
23. + exchange. Nature 392, 626-630
24. Weinman, E. J., Hall, R. A., Friedman, P. A., Liu-Chen, L. Y., and Shenolikar, S. (2006) The association of NHERF adaptor proteins with G protein-coupled receptors and receptor tyrosine kinases. Annu. Rev. Physiol. 68, 491-505
25. Simon, J., Filippov, A. K., Göransson, S., Wong, Y. H., Frelin, C., Michel, A. D., Brown, D. A., and Barnard, E. A. (2002) Characterization and channel coupling of the P2Y12 nucleotide receptor of brain capillary endothelial cells. J. Biol. Chem. 277, 31390-31400 (Pubitemid 34968938)
26. Zhang, F. L., Luo, L., Gustafson, E., Lachowicz, J., Smith, M., Qiao, X., Liu, Y. H., Chen, G., Pramanik, B., Laz, T. M., Palmer, K., Bayne, M., and Monsma, F. J., Jr. (2001) ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. J. Biol. Chem. 276, 8608-8615
27. Puthenveedu, M. A., and von Zastrow, M. (2006) Cargo regulates clathrincoated pit dynamics. Cell 127, 113-124 (Pubitemid 44466633)
28. 2-adrenergic receptors determines subtype specificity of arrestin interaction. J. Biol. Chem. 277, 43247-43252
29. Wang, B., Yang, Y., Abou-Samra, A. B., and Friedman, P. A. (2009) NHERF1 regulates parathyroid hormone receptor desensitization. Interference with β-arrestin binding. Mol. Pharmacol. 75, 1189-1197
30. Sneddon, W. B., Syme, C. A., Bisello, A., Magyar, C. E., Rochdi, M. D., Parent, J. L., Weinman, E. J., Abou-Samra, A. B., and Friedman, P. A. (2003) Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50). J. Biol. Chem. 278, 43787-43796 (Pubitemid 37346007)
31. Klenk, C., Vetter, T., Zürn, A., Vilardaga, J. P., Friedman, P. A., Wang, B., and Lohse, M. J. (2010) Formation of a ternary complex among NHERF1, β-arrestin, and parathyroid hormone receptor. J. Biol. Chem. 285, 30355-30362
32. +-exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains. J. Biol. Chem. 286, 35020-35029
33. + exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer. J. Biol. Chem. 285, 34653-34664
34. Stalker, T. J., Wu, J., Morgans, A., Traxler, E. A., Wang, L., Chatterjee, M. S., Lee, D., Quertermous, T., Hall, R. A., Hammer, D. A., Diamond, S. L., and Brass, L. F. (2009) Endothelial cell-specific adhesion molecule (ESAM) localizes to platelet-platelet contacts and regulates thrombus formation in vivo. J. Thromb. Haemost. 7, 1886-1896
35. Ardura, J. A., and Friedman, P. A. (2011) Pharmacol. Rev. 63, 882-900
36. Wheeler, D., Sneddon, W. B., Wang, B., Friedman, P. A., and Romero, G. (2007) NHERF-1 and the cytoskeleton regulate the traffic and membrane dynamics of G protein-coupled receptors. J. Biol. Chem. 282, 25076-25087 (Pubitemid 47347543)
37. + exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4. Cancer Res. 68, 4802-4809
38. Mahon, M. J. (2009) The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells. Mol. Endocrinol. 23, 1691-1701
39. Paasche, J. D., Attramadal, T., Kristiansen, K., Oksvold, M. P., Johansen, H. K., Huitfeldt, H. S., Dahl, S. G., and Attramadal, H. (2005) Subtypespecific sorting of the ETA endothelin receptor by a novel endocytic recycling signal for G protein-coupled receptors. Mol. Pharmacol. 67, 1581-1590 (Pubitemid 40594157)