Perturbed heme binding is responsible for the blistering phenotype associated with mutations in the Caenorhabditis elegans dual oxidase 1 (DUOX1) peroxidase domain

Journal of Biological Chemistry

Volumn 285, Issue 52, 2010, Pages 40991-41000

  Meitzler, Jennifer L ^a   Brandman, Relly ^a   Ortiz De Montellano, Paul R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS; CATALYTIC RESIDUE; CELLULAR SIGNALING; COVALENTLY BOUND; CURRENT MODELS; ELEGANS; HEME BINDING; HEME GROUP; HISTIDINE RESIDUES; HOMOLOGY MODELS; INNATE IMMUNITY; MOLECULAR DYNAMICS SIMULATIONS; N-TERMINALS; NADPH OXIDASE; SUPEROXIDES; THYROID HORMONES; WILD TYPES;

AMINO ACIDS; BIOCHEMISTRY; CATALYSTS; ENZYMES; MOLECULAR DYNAMICS; OXYGEN; REACTION KINETICS;

PORPHYRINS;

HEME;

ARTICLE; BINDING AFFINITY; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; HEME; HUMANS; MODELS, MOLECULAR; MUTATION; NADPH OXIDASE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TYROSINE;

CAENORHABDITIS ELEGANS;

EID: 78650390759     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.170902     Document Type: Article

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