Glaucocalyxin A induces apoptosis in human leukemia HL-60 cells through mitochondria-mediated death pathway

Toxicology in Vitro

Volumn 25, Issue 1, 2011, Pages 51-63

  Gao, Li Wen ^a   Zhang, Jian ^a,b   Yang, Wen Hua ^a   Wang, Bin ^c   Wang, Jian Wen ^a  

^a SOOCHOW UNIVERSITY   (China)

^b Suzhou Liyuan Pharmaceuticals   (China)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Glaucocalyxin A; HL 60 cells; Mitochondria; ROS

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; GLAUCOCALYXIN A; MITOCHONDRIAL DNA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL LEVEL; CELL STRUCTURE; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DNA FRAGMENTATION; DOSE RESPONSE; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; PROTEIN SECRETION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; APOPTOSIS; BIOLOGICAL MARKERS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES, KAURANE; DNA FRAGMENTATION; DRUGS, CHINESE HERBAL; G1 PHASE; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

JAPONICA; RABDOSIA;

EID: 78650521345     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.09.006     Document Type: Article

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