Mutant interleukin-4/13 signaling blockade successfully suppresses acute phase inflammation

Archives of Dermatological Research

Volumn 305, Issue 3, 2013, Pages 241-247

  Nakanishi, Takehisa ^a   Yamanaka, Keiichi ^a   Kakeda, Masato ^a   Tsuda, Kenshiro ^a   Mizutani, Hitoshi ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

Atopic dermatitis; Contact hypersensitivity; Mutant IL 4; Skin grafting

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; MESSENGER RNA; OXAZOLONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; EAR; HELPER CELL; HISTOLOGY; KERATINOCYTE; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIGNAL TRANSDUCTION; SKIN TRANSPLANTATION; SUPPLEMENTATION; THICKNESS; TRANSGENIC MOUSE;

ACUTE-PHASE REACTION; ANIMALS; DERMATITIS, ATOPIC; GATA3 TRANSCRIPTION FACTOR; INTERLEUKIN-13; INTERLEUKIN-4; MAST CELLS; MICE; MICE, TRANSGENIC; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKIN TRANSPLANTATION; STAT6 TRANSCRIPTION FACTOR;

EID: 84876472759     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-012-1302-9     Document Type: Article

References (25)

1. Akdis CA, Akdis M, Trautmann A, Blaser K (2000) Immune regulation in atopic dermatitis. Curr Opin Immunol 12(6):641-646
2. Aversa G, Punnonen J, Cocks BG, de Waal Malefyt R, Vega F Jr, Zurawski SM, Zurawski G, de Vries JE (1993) An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors. J Exp Med 178(6):2213-2218
3. Carballido JM, Schols D, Namikawa R, Zurawski S, Zurawski G, Roncarolo MG, de Vries JE (1995) IL-4 induces human B cell maturation and IgE synthesis in SCID-hu mice. Inhibition of ongoing IgE production by in vivo treatment with an IL-4/IL-13 receptor antagonist. J Immunol 155(9):4162-4170
4. Del Prete G (1992) Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy. Allergy 47(5):450-455
5. Elbe-Burger A, Egyed A, Olt S, Klubal R, Mann U, Rappersberger K, Rot A, Stingl G (2002) Overexpression of IL-4 alters the homeostasis in the skin. J Invest Dermatol 118(5):767-778
6. Grunewald SM, Kunzmann S, Schnarr B, Ezernieks J, Sebald W, Duschl A (1997) A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction. J Biol Chem 272(3):1480-1483
7. Henderson WR Jr, Chi EY, Maliszewski CR (2000) Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma. J Immunol 164(2):1086-1095
8. Herz U, Bunikowski R, Renz H (1998) Role of T cells in atopic dermatitis. New aspects on the dynamics of cytokine production and the contribution of bacterial superantigens. Int Arch Allergy Immunol 115(3):179-190
9. Kay AB, Ying S, Varney V, Gaga M, Durham SR, Moqbel R, Wardlaw AJ, Hamid Q (1991) Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects. J Exp Med 173(3):775-778
10. Konishi H, Tsutsui H, Murakami T, Yumikura-Futatsugi S, Yamanaka K, Tanaka M, Iwakura Y, Suzuki N, Takeda K, Akira S, Nakanishi K, Mizutani H (2002) IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions. Proc Natl Acad Sci USA 99(17):11340-11345. doi: 10.1073/pnas.152337799
11. Kruse N, Shen BJ, Arnold S, Tony HP, Muller T, Sebald W (1993) Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation. EMBO J 12(13):5121-5129
12. Kruse N, Tony HP, Sebald W (1992) Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement. EMBO J 11(9):3237-3244
13. Leung DY (1997) Atopic dermatitis: immunobiology and treatment with immune modulators. Clin Exp Immunol 107(Suppl 1):25-30
14. Mori H, Yamanaka K, Matsuo K, Kurokawa I, Yasutomi Y, Mizutani H (2009) Administration of Ag85B showed therapeutic effects to Th2-type cytokine-mediated acute phase atopic dermatitis by inducing regulatory T cells. Arch Dermatol Res 301(2):151-157. doi: 10.1007/s00403-008-0873-y
15. Morioka T, Yamanaka K, Mori H, Omoto Y, Tokime K, Kakeda M, Kurokawa I, Gabazza EC, Tsubura A, Yasutomi Y, Mizutani H (2009) IL-4/IL-13 antagonist DNA vaccination successfully suppresses Th2 type chronic dermatitis. Br J Dermatol 160(6):1172-1179. doi: 10.1111/j.1365-2133.2009.09069.x
16. Nishikubo K, Murata Y, Tamaki S, Sugama K, Imanaka-Yoshida K, Yuda N, Kai M, Takamura S, Sebald W, Adachi Y, Yasutomi Y (2003) A single administration of interleukin-4 antagonistic mutant DNA inhibits allergic airway inflammation in a mouse model of asthma. Gene Ther 10(26):2119-2125
17. Ricci M, Matucci A, Rossi O (1997) IL-4 as a key factor influencing the development of allergen-specific Th2-like cells in atopic individuals. J Investig Allergol Clin Immunol 7(3):144-150
18. Schnarr B, Ezernieks J, Sebald W, Duschl A (1997) IL-4 receptor complexes containing or lacking the gamma C chain are inhibited by an overlapping set of antagonistic IL-4 mutant proteins. Int Immunol 9(6):861-868
19. Smerz-Bertling C, Duschl A (1995) Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor. J Biol Chem 270(2):966-970
20. Tomkinson A, Duez C, Cieslewicz G, Pratt JC, Joetham A, Shanafelt MC, Gundel R, Gelfand EW (2001) A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immunol 166(9):5792-5800
21. Tony HP, Shen BJ, Reusch P, Sebald W (1994) Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency. Eur J Biochem 225(2):659-665
22. Vannier E, de Waal Malefyt R, Salazar-Montes A, de Vries JE, Dinarello CA (1996) Interleukin-13 (IL-13) induces IL-1 receptor antagonist gene expression and protein synthesis in peripheral blood mononuclear cells: inhibition by an IL-4 mutant protein. Blood 87(8):3307-3315
23. Yamanaka K, Tanaka M, Tsutsui H, Kupper TS, Asahi K, Okamura H, Nakanishi K, Suzuki M, Kayagaki N, Black RA, Miller DK, Nakashima K, Shimizu M, Mizutani H (2000) Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18. J Immunol 165(2):997-1003 ji-v165n2p997 [pii]
24. Yoshimoto T, Mizutani H, Tsutsui H, Noben-Trauth N, Yamanaka K, Tanaka M, Izumi S, Okamura H, Paul WE, Nakanishi K (2000) IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. Nat Immunol 1(2):132-137. doi: 10.1038/7781177811
25. Zurawski SM, Chomarat P, Djossou O, Bidaud C, McKenzie AN, Miossec P, Banchereau J, Zurawski G (1995) The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor. J Biol Chem 270(23):13869-13878