IL-4 receptor complexes containing or lacking the γ(c) chain are inhibited by an overlapping set of antagonistic IL-4 mutant proteins

International Immunology

Volumn 9, Issue 6, 1997, Pages 861-868

  Schnarr, Bernd ^a   Ezernieks, Juris ^a   Sebald, Walter ^a   Duschl, Albert ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Antagonist; Cytokine; Inhibitor; Type 2 receptor

Indexed keywords

ARGININE; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; MUTANT PROTEIN; SERINE; TYROSINE;

ARTICLE; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIGENS, CD; CARCINOMA, RENAL CELL; CELL DIVISION; GROWTH INHIBITORS; HUMANS; INTERLEUKIN-4; LIGANDS; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-4; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0030950732     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.6.861     Document Type: Article

References (47)

1. Liu, J. 1993. FK506 and cyclosporin: molecular probes for studying intracellular signal transduction. Trends Pharmacol. Sci. 14:182.
2. Finkelman, F. D., Madden, K. B., Morris, S. C., Holmes, J. M., Boiani, N., Katona, I. M. and Maliszewski, C. R. 1993. Anticytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anticytokine antibody complexes. J. Immunol. 151:1235.
3. Maliszewski, C. R., Sato, T. A., Davison, B., Jacobs, C. A., Finkelman, F. D. and Fanslow, W. C. 1994. In vivo biological effects of recombinant soluble interleukin-4 receptor. Proc, Soc. Exp. Biol. Med. 206:233.
4. Duschl, A., Müller, T. and Sebald, W. 1995. Antagonistic mutant proteins of interleukin-4. Behring Inst. Mitt. 96:87.
5. Mosmann, T. R. and Sad, S. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more, Immunol. Today 17:138.
6. Kühn, R., Rajewsky, K. and Müller, W. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254:707.
7. Kopf, M., Le Gros, G., Bachmann, M., Lamers, M. C., Bluethmann, H. and Köhler, G. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362:245.
8. Renz, H., Bradley, K., Enssle, K., Loader, J. E. and Gelfand, E. W. 1996. Prevention of the development of immediate hypersensitivity and airway hyperresponsiveness following in vivo treatment with soluble IL-4 receptor. Int. Arch. Allergy Immunol. 109:167.
9. Carballido, J. M., Aversa, G., Schols, D., Punnonen, J. and de Vries, J. E. 1995. Inhibition of human IgE synthesis in vitro and in SCID-hu mice by an interleukin-4 receptor antagonist. Int. Arch. Allergy Immunol. 107:304.
10. Kruse, N., Tony, H. P. and Sebald, W. 1992. Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement. EMBO J. 11:3237.
11. Kruse, N., Shen, B. J., Arnold, S., Tony, H. P., Müller, T. and Sebald, W. 1993. Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation. EMBO J. 12:5121.
12. Zurawski, S. M., Vega, F., Huyghe, B. and Zurawski, G. 1993. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J. 12:2663.
13. Tony, H.-P., Shen, B.-J., Reusch, P. and Sebald, W. 1994. Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency. Eur. J. Biochem. 225:659.
14. Smerz-Bertling, C. and Duschl, A. 1995. Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor. J. Biol. Chem. 270:966.
15. Aversa, G., Punnonen, J., Cocks, B. G., de Waal Malefyt, R., Vega, F., Zurawski, S. M., Zurawski, G. and de Vries, J. E. 1993 An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors. J. Exp. Med. 178:2213.
16. König, B., Fischer, A. and König, W. 1995. Modulation of cellbound and soluble CD23, spontaneous and ongoing IgE synthesis of human peripheral blood mononuclear cells by soluble IL-4 receptors and the partial antagonistic IL-4 mutant protein IL-4 (Y124D). Immunology 85:604.
17. Duschl, A. and Sebald, W. 1996. Transmembrane and intracellular signalling by interleukin-4: receptor dimerization and beyond. Eur, Cytokine. Netw. 7:37.
18. Watanabe, S., Kondo, M., Takatsu, K., Sugamura, K. and Arai, K.-I. 1995. Involvement of the interleukin-2 receptor gamma subunit in interleukin-4-dependent activation of mouse hematopoietic cells and splenic B cells. Eur. J. Immunol. 25:126.
19. Kotanides, H. and Reich, N. C. 1993. Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science 262:1265.
20. de Wit, H., Hendriks, D. W., Halie, M. R. and Vellenga, E. 1994. Interleukin-4 receptor regulation in human monocytic cells. Blood 84:608.
21. Murata, T., Noguchi, P. D. and Puri, R. K. 1996. Receptors for Interleukin (IL)-4 do not associate with the common y chain, and IL-4 induces the phosphorylation of Jak2 tyrosine kinase in human colon carcinoma cells. J. Biol. Chem. 270:30829.
22. He, Y.-W. and Malek, T. R. 1995. The IL-2 receptor γc chain does not function as a subunit shared by the IL-4 and IL13 receptors J. Immunol. 155:9.
23. Matthews, D. J., Clark, P. A., Herbert, J., Morgan, G., Armitage, R. J., Kinnon, C., Minty, A., Grabstein, K. H., Caput, D., Ferrara, P. and Callard, R. 1995. Function of the interleukin-2 (IL-2) receptor γ-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13 and IL-15. Blood 85:38.
24. Aman, M. J., Tayebi, N., Obiri, N. I., Puri, R. K., Modi, W. S. and Leonard, W. J. 1996. cDNA cloning and characterization of the human interleukin 13 receptor α chain. J. Biol. Chem. 271:29265.
25. Duschl, A., Jahn, U., Bertling, C. and Sebald, W. 1992. A comparison of assays for the response of primary human T-cells upon stimulation with interleukin-2, interleukin-4 and interleukin-7. Eur. Cytokine Netw. 3:97.
26. Weigel, U., Meyer, M. and Sebald, W. 1989. Mutant proteins of human interleukin 2. Eur. J. Biochem. 180:295.
27. Kruse, N., Lehrnbecher, T. and Sebald, W. 1991. Site-directed mutagenesis reveals the importance of disulfide bridges and aromatic residues for structure and proliferative activity of human interleukin-4. FEBS Lett. 286:58.
28. Reusch, P., Arnold, S., Hausser, C., Wagner, K., Weston, B. and Sebald, W. 1994. Neutralizing monoclonal antibodies define two different functional sites in human interleukin-4. Eur J. Biochem. 222:491.
29. Ishii, N., Takeshita, T., Kimura, Y., Tada, K., Kondo, M., Nakamura, M. and Sugamura, K. 1994. Expression of the IL-2 receptor γ chain on various populations in human peripheral blood. Int. Immunol. 6:1273.
30. Russell, S. M., Keegan, A. D., Harada, N., Nakamura, Y., Noguchi, M., Leland, P., Friedman, M. C., Miyajima, A., Puri, R, K., Paul, W. E. and Leonard, W. J. 1993. Interleukin-2 receptor γ chain: a functional component of the interleukin-4 receptor. Science 262:1880.
31. Chomczynski, P. and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem. 162:156.
32. Simm, A., Hoppe, V., Tatje, D., Schenzinger, A. and Hoppe, J. 1992. PDGF-AA effective stimulates early events but has no mitogenic activity in AKR-2B mouse fibroblasts. Exp. Cell Res. 201:192.
33. Boshart, M., Klüppel, M., Schmidt, A., Schütz, A. and Luchow, B. 1992. Reporter constructs with low background activity utilizing the cat gene. Gene 110:129.
34. Nordeen, S, K. 1988. Luciferase reporter gene vectors for analysis of promoters and enhancers. Bio Techniques 6:454.
35. Ezernieks, J., Schnarr, B., Metz, K. and Duschl, A. 1996. The human IgE germline promoter is regulated by interleukin-4, interleukin-13, interferon-α and interferon-γ via an interferon-γ-activated site and its flanking regions. Eur. J. Biochem. 240:667.
36. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 193:248.
37. Cabrillat, H., Galizzi, J.-P., Djossou, O., Arai, N., Yokota, T., Arai, K. and Banchereau, J. 1987. High affinity binding of human interleukin 4 to cell lines. Biochem. Biophys. Res. Commun. 149:995.
38. Duschl, A. 1995. An antagonistic mutant of interleukin-4 fails to recruit γc into the receptor complex. Characterization by specific cross-linking. Eur. J. Biochem. 228:305.
39. Obiri, N. I., Debinski, W., Leonard, W. J. and Puri, R. K. 1995, Receptor for interleukin 13. J. Biol. Chem. 270:8797.
40. Obiri, N. I., Tandon, N. and Puri, R. K. 1995. Up-regulation of intercellular adhesion molecule 1 (ICAM-1) on human renal cell carcinoma cells by interleukin-4. Int. J. Cancer 61:635.
41. Hou, J., Schindler, U., Henzel, W. J., Ho, T. C., Brasseur, M. and McKnight, S. L. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265:1701.
42. Kotanides, H., Moczygemba, M., White, M. F. and Reich, N. C. 1995. Characterization of the interleukin-4 nuclear activated factor/ STAT and its activation independent of the insulin receptor substrate proteins. J. Biol. Chem. 270:19481.
43. Müller, T., Sebald, W. and Oschkinat, H. 1994. Antagonist design through forced electrostatic mismatch. Nature Struct. Biol. 1:674.
44. Vita, N., Lefort, S., Laurent, P., Caput, D. and Ferrara, P. 1995. Characterization and comparison of the interleukin 13 receptor with the interleukin 4 receptor on several cell types. J. Biol. Chem. 270:3512.
45. Caput, D., Laurent, P., Kaghad, M., Lelias, J.-M., Lefort, S., Vita, N. and Ferrara, P. 1996. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor α chain. J. Biol. Chem. 271:16921.
46. Bönsch, D., Kammer, W., Lischke, A. and Friedrich, K. 1995. Species-specific agonist/antagonist activities of human interleukin-4 variants suggest distinct ligand binding properties of human and murine common receptor gamma chain. J. Biol. Chem. 270:8452.
47. Müller, T., Dieckmann, T., Sebald, W. and Oschkinat, H. 1994. Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy. J. Mol. Biol. 237:424.