Randomized codon mutagenesis reveals that the HIV Rev arginine-rich motif is robust to substitutions and that double substitution of two critical residues alters specificity

Journal of Molecular Recognition

Volumn 26, Issue 6, 2013, Pages 286-296

  Possik, Elite J ^a   Bou Sleiman, Maroun S ^b   Ghattas, Ingrid R ^c   Smith, Colin A ^c  

^a MCGILL UNIVERSITY   (Canada)

^b EPFL   (Switzerland)

^c AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

arginine rich motif; HIV rev; neutral evolution; Protein RNA recognition; Rev aptamer I; Rev response element

Indexed keywords

ARGININE; REV PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CODON; CONFORMATION; ENZYME SPECIFICITY; GENETICS; MOLECULAR GENETICS; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN BINDING; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARGININE; BASE SEQUENCE; CODON; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; REV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ENTEROBACTERIA PHAGE LAMBDA;

EID: 84876465842     PISSN: 09523499     EISSN: 10991352     Source Type: Journal    
DOI: 10.1002/jmr.2272     Document Type: Article

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