Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma

Human Pathology

Volumn 44, Issue 5, 2013, Pages 766-776

  Morris, Jacqueline F ^a   Sul, Jai Yoon ^a   Kim, Min Sun ^b   Klein Szanto, Andres J ^c   Schochet, Terri ^a   Rustgi, Anil ^d   Eberwine, James H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Wonkwang University   (South Korea)

^c FOX CHASE CANCER CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Adenocarcinoma; Colorectal cancer; Elk 1; Phosphorylation; Tumor grade

Indexed keywords

THREONINE; TRANSCRIPTION FACTOR ELK 1;

ARTICLE; CANCER GRADING; COLON; COLON ADENOCARCINOMA; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; RECTUM CARCINOMA; STOMACH ADENOCARCINOMA; TISSUE MICROARRAY; TRANSCRIPTION REGULATION; TUMOR DIFFERENTIATION;

ADENOCARCINOMA; AMINO ACID SEQUENCE; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; COLON; COLONIC NEOPLASMS; ETS-DOMAIN PROTEIN ELK-1; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASMS; PHOSPHORYLATION; THREONINE; TRANSCRIPTIONAL ACTIVATION;

EID: 84876463656     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2012.08.001     Document Type: Article

References (35)

1. V.N. Rao, and E.S. Reddy Elk-1 proteins interact with MAP kinases Oncogene 9 1994 1855 1860 (Pubitemid 24194150)
2. W. Li, C. Marshall, and L. Mei Srcasm modulates EGF and Src-kinase signaling in keratinocytes J Biol Chem 280 2005 6036 6046 (Pubitemid 40280087)
3. R. Janknecht, R. Zinck, and W.H. Ernst Functional dissection of the transcription factor Elk-1 Oncogene 9 1994 1273 1278 (Pubitemid 24095040)
4. V. Sgambato, P. Vanhoutte, and C. Pages In vivo expression and regulation of Elk-1, a target of the extracellular-regulated kinase signaling pathway, in the adult rat brain J Neurosci 18 1998 214 226 (Pubitemid 28046783)
5. TCF Nature 354 1991 531 534
6. H. Gille, M. Kortenjann, and O. Thomae ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation EMBO J 14 1995 951 962
7. R. Marais, J. Wynne, and R. Treisman The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain Cell 73 1993 381 393 (Pubitemid 23123315)
8. H. Gille, T. Strahl, and P.E. Shaw Activation of ternary complex factor Elk-1 by stress-activated protein kinases Curr Biol 5 1995 1191 1200
9. R.D. York, H. Yao, and T. Dillon Rap1 mediates sustained MAP kinase activation induced by nerve growth factor Nature 392 1998 622 626 (Pubitemid 28207722)
10. N. Shao, Y. Chai, and J.Q. Cui Induction of apoptosis by Elk-1 and deltaElk-1 proteins Oncogene 17 1998 527 532 (Pubitemid 28395918)
11. Y. Chai, G. Chipitsyna, and J. Cui c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells Oncogene 20 2001 1357 1367 (Pubitemid 32269940)
12. E.P. Booy, E.S. Henson, and S.B. Gibson Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signaling pathway contributing to cell survival in breast cancer Oncogene 30 2011 2367 2378
13. S. Fujii, K. Fukamachi, and H. Tsuda RAS oncogenic signal upregulates EZH2 in pancreatic cancer Biochem Biophys Res Commun 417 2011 1074 1079
14. M. Tsujii, and R.N. DuBois Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2 Cell 83 1995 493 501
15. L.E. Barrett, E.J. Van Bockstaele, and J.Y. Sul Elk-1 associates with the mitochondrial permeability transition pore complex in neurons Proc Natl Acad Sci U S A 103 2006 5155 5160
16. L.E. Barrett, J.Y. Sul, and H. Takano Region-directed phototransfection reveals the functional significance of a dendritically synthesized transcription factor Nat Methods 3 2006 455 460 (Pubitemid 43811557)
17. A. Sharma, L.M. Callahan, and J.Y. Sul A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases PLoS One 5 2010 e9002
18. J.T. Romer, H. Kimura, and S. Magdaleno Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice Cancer Cell 6 2004 229 240 (Pubitemid 39222036)
19. K. Sasai, J.T. Romer, and H. Kimura Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor Cancer Res 67 2007 2871 2877
20. G. Chatel, C. Ganeff, and N. Boussif Hedgehog signaling pathway is inactive in colorectal cancer cell lines Int J Cancer 121 2007 2622 2627 (Pubitemid 350136404)
21. K. Yukawa, N. Shirasawa, and A. Ohshima Death-associated protein kinase localization to human renal tubule cells, and increased expression of chronic obstructive uropathy in rats J Nephrol 17 2004 26 33 (Pubitemid 38444626)
22. J.K. Heath Transcriptional networks and signaling pathways that govern vertebrate intestinal development Curr Top Dev Biol 90 2010 159 192
23. M.P. Verzi, and R.A. Shivdasani Wnt signaling in gut organogenesis Organogenesis 4 2008 87 91 (Pubitemid 351881305)
24. S. Segditsas, and I. Tomlinson Colorectal cancer and genetic alterations in the Wnt pathway Oncogene 25 2006 7531 7537 (Pubitemid 44885752)
25. J. Lin, X. Wang, and R.I. Dorsky Progenitor expansion in apc mutants is mediated by Jak/Stat signaling BMC Dev Biol 11 2011 73
26. Y. Peng, H. Li, and M. Wu NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human colorectal cancer Biochim Biophys Sin 41 2009 504 514
27. A.J. Whitmarsh, S.H. Yang, and M.S. Su Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors Mol Cell Biol 17 1997 2360 2371 (Pubitemid 27175117)
28. L. Zhang, S.H. Yang, and A.D. Sharrocks Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1 Mol Cell Biol 27 2007 2861 2869 (Pubitemid 46581302)
29. A. Tyagi, R. Agarwai, and C. Agarwal Grape seed extract inhibits EGF-induced and constitutively active mitogeneic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis Oncogene 22 2003 1302 1316 (Pubitemid 36384591)
30. P.A. Konstantinopoulos, G.P. Vandoros, and G. Sotiropoulou-Bonikou NF-kB/PPARγ and/or AP-1/PPARγ "on/off" switches and the induction of CBP in colon adenocarcinomas: correlation with COX-2 expression Int J Colorectal Dis 22 2007 57 68 (Pubitemid 44742340)
31. T. Okegawa, R.C. Pong, and Y. Li The role of cell adhesion molecule in cancer progression and its application in cancer therapy Acta Biochim Pol 51 2004 445 457 (Pubitemid 38969306)
32. L. Petruzzelli, M. Takami, and H.D. Humes Structure and function of cell adhesion molecules Am J Med 106 1999 467 476 (Pubitemid 29190602)
33. X. Xie, C.Y. Wang, and Y.X. Cao Expression pattern of epithelial cell adhesion molecule on normal and malignant colon tissues World J Gastroenterol 11 2005 344 347 (Pubitemid 40125236)
34. G. Pages, P. Lenormand, and G. L'Allemain Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation Proc Natl Acad Sci U S A 90 1993 8319 8323 (Pubitemid 23277659)
35. A.E. Aplin, B.P. Hogan, and J. Tomeu Cell adhesion differentially regulates the nucelocytoplasmic distribution of active MAP kinases J Cell Sci 115 2002 2781 2790 (Pubitemid 34846518)