Cardioprotective effects of different flavonoids against myocardial ischaemia/reperfusion injury in Langendorff-perfused rat hearts

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 5, 2013, Pages 750-756

  Testai, Lara ^a   Martelli, Alma ^a   Cristofaro, Mario ^a   Breschi, Maria C ^a   Calderone, Vincenzo ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

cardioprotection; cardiovascular risk; flavonoids; ischaemic preconditioning; myocardial ischaemia reperfusion

Indexed keywords

4' HYDROXYFLAVANONE; 5 METHOXYFLAVONE; 6 HYDROXYFLAVANONE; 7 HYDROXYFLAVONE; APIGENIN; CHRYSIN; FLAVONOID; NARINGENIN; PRIMULETIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG EFFECT; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; ISOLATED HEART; MALE; NONHUMAN; RAT; REPERFUSION INJURY;

ANIMALS; CARDIOVASCULAR AGENTS; FLAVONES; FLAVONOIDS; HEART; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR;

EID: 84876462871     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12032     Document Type: Article

References (36)

1. Hertog MG, et al. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993; 342: 1007-1011.
2. Keli SO, et al. Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Int Med 1996; 156: 637-642.
3. Johnston C,. Functional foods as modifiers of cardiovascular disease. Am J Lifestyle Med 2009; 3 (Suppl. 1): 39S-43S.
4. Huxley RR, Neil HA,. The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. Eur J Clin Nutr 2003; 57: 904-908.
5. Perez-Vizcaino F, et al. Antihypertensive effects of the flavonoid quercetin. Pharmacol Rep 2009; 61: 67-75.
6. Duarte J, et al. Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships. Gen Pharmacol 1993; 24: 857-862.
7. Duarte J, et al. Vasorelaxant effects of the bioflavonoid chrysin in isolated rat aorta. Planta Med 2001a; 67: 567-569.
8. Duarte J, et al. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol 2001b; 133: 117-124.
9. Calderone V, et al. Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels. Naunyn Schmiedebergs Arch Pharmacol 2004; 370: 290-298.
10. Edwards RL, et al. Quercetin reduces blood pressure in hypertensive subjects. J Nutr 2007; 137: 2405-2411.
11. Perez-Vizcaino F, Duarte J,. Flavonols and cardiovascular disease. Mol Aspects Med 2010; 31: 478-494.
12. Loke WM, et al. Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. Arterioscler Thromb Vasc Biol 2010; 30: 749-757.
13. Hayek T, et al. Reduced progression of atherosclerosis in apolipoprotein E deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler Thromb Vasc Biol 1997; 17: 2744-2752.
14. Beretz A, et al. Inhibition of aggregation and secretion of human platelets by quercetin and other flavonoids: structure-activity relationships. Agents Actions 1982; 12: 382-387.
15. Ibarra M, et al. Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria. Planta Med 2002; 68: 307-310.
16. Ibarra M, et al. Effects of the flavonoid quercetin and its methylated metabolite isorhamnetin in isolated arteries from spontaneously hypertensive rats. Planta Med 2003; 69: 995-1000.
17. Ajay M, et al. Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: comparative study with ascorbic acid. Clin Exp Pharmacol Physiol 2006; 33: 345-350.
18. Rice-Evans CA, et al. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 1996; 20: 933-956.
19. Pietta PG,. Flavonoids as antioxidants. J Nat Prod 2000; 63: 1035-1042.
20. Chan EC, et al. Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. J Cardiovasc Pharmacol 2000; 35: 326-333.
21. Saponara S, et al. (+/-)-Naringenin as large conductance Ca(2+)-activated Potassium (BKCa) channel opener in vascular smooth muscle cells. Br J Pharmacol 2006; 149: 1013-1021.
22. Li Y, et al. The discovery of novel openers of Ca2+-dependent large-conductance Potassium channels: pharmacophore search and physiological evaluation of flavonoids. Bioorg Med Chem Lett 1997; 7: 759-762.
23. Zhang HT, et al. Daidzein relaxes rat cerebral basilar artery via activation of large-conductance Ca2+-activated Potassium channels in vascular smooth muscle cells. Eur J Pharmacol 2010; 630: 100-106.
24. Dong L, et al. Vitexin protects against myocardial ischemia/reperfusion injury in Langendorff-perfused rat hearts by attenuating inflammatory response and apoptosis. Food Chem Toxicol 2011; 49: 3211-3216.
25. Lu N, et al. Orientin-induced cardioprotection against reperfusion is associated with attenuation of mitochondrial permeability transition. Planta Med 2011; 77: 984-991.
26. Fang F, et al. Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K/Akt pathway in simulated ischemia/reperfusion. Pharmacology 2011; 88: 149-158.
27. Guler A, et al. Proanthocyanidin prevents myocardial ischemic injury in adult rats. Med Sci Monit 2011; 17: BR326-BR331.
28. Pogula BK, et al. Morin protects heart from beta-adrenergic-stimulated myocardial infarction: an electrocardiographic, biochemical, and histological study in rats. J Physiol Biochem 2012; 68: 433-446.
29. Arumugam S, et al. Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling. Free Radic Res 2012; 46: 154-163.
30. Thomas CJ, et al. Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK. Eur J Pharmacol 2011; 658: 160-167.
31. Wang CZ, et al. Botanical flavonoids on coronary heart disease. Am J Chin Med 2011; 39: 661-671.
32. Stoclet JC, Schini-Kerth V,. Dietary flavonoids and human health. Ann Pharmacother 2011; 69: 78-90.
33. Cao J, et al. The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake. Br J Nutr 2010; 103: 249-255.
34. Lecour S, et al. Natural polyphenols and cardioprotection. Mini Rev Med Chem 2011; 11: 1191-1199.
35. Calderone V, et al. Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel. Biochem Pharmacol 2010; 79: 39-47.
36. Ding CZ, et al. Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines. J Med Chem 1999; 42: 3711-3717.